Endocrine Abstracts

Introduction: Cushing’s syndrome(CS) is associated with high morbidity and mortality which warrants a good screening test that is less laborious. We explored the possibility of using urine spot cortisol:creatinine ratio (UCCR) as a new screening test for Cushing’s syndrome.Aims and objectives: To study the efficacy of UCCR as a screening test for patients with Cushing’s syndrome.To compare UCCR in patients with CS, o...

Osteoporosis in men is increasingly being recognized as a public health issue. Thirty percent of hip fractures occur in men, and one in eight fractures occurs in men above 50 years of age.Objectives: To assess the prevalence of osteoporosis in healthy male subjects using Bone Mineral Density (BMD) as measured by Dual energy X-ray absorptiometry (DXA), and to study the influence of various factors which influence BMD.Methods: Health...

Introduction: Hip fractures are the most serious osteoporotic fractures and difficult to prevent them without a precise knowledge of the causative factors. The risk factors, which precipitate hip fracture in elderly may vary according to the local customs and practices. Indian data on risk factors for hip fractures are scant. The present study was undertaken to assess the various risk factors leading to femoral neck fracture in postmenopausal women and also to define the thres...

A 19-year-old, female of West African descent presented with a 5 months history of thyrotoxicosis. The GP had commenced carbimazole. She had continuing clinical and biochemical thyrotoxicosis TSH <0.01 (0.3–5.5 mU/l), FT4 68.0 (9–20 pmol/l) and FT3 18.9 (3.4–5.6 pmol/l). Thyroid antibodies were present at elevated titre and technetium uptake scanning showed toxic diffuse hyperplasia with an uptake function of 37%, confirming Graves&#146...

Background and objective: Widespread use of highly active anti-retroviral therapy (HAART) has led to a decrease in morbidity and mortality with this infection. HAART is also associated with body fat redistribution, insulin resistance and dyslipidemia, well known risk factors for cardiovascular disease. The prevalence of fat redistribution in studies ranges from 11 to 83%. The objective of this study was to look at changes in body composition in HIV infected men and to determin...

There is limited evidence for the role of screening for Cushing’s syndrome (CS). Patients referred to the specialist medical weight management service at Musgrove Park Hospital have routinely been screened for CS with either an overnight dexamethasone suppression test (ODST) or two 24hour urinary free cortisol (UFC) if evidence of dysglycaemia. We retrospectively analysed the results of all patients referred to the service between 2013–2016. 794 patients were seen as...

Background: Hyponatremia is the commonest electrolyte abnormality encountered in clinical practice. It is associated with increased mortality and prolonged length of stay. Errors in establishing the aetiology of hyponatremia can lead to inappropriate treatment with adverse outcomes. An accurate diagnosis requires a careful clinical and biochemical assessment. An audit was undertaken to determine current practice at University Hospitals Bristol.Method: A ...

Aims and objectives: This study was undertaken to look at the agreement between the hologic database (HD) based on NHANES bone mineral density (BMD) data in Caucasians and the ICMR database (ICMRD) published in 2010 in defining normal and subnormal BMD in subjects with or without hip fracture and to arrive at a BMD cut off which has a high sensitivity of predicting fracture.Materials and methods: A cross sectional study of 3098 subjects (men-341 and wome...

Background: Risperidone is a widely used antipsychotic, known to cause secondary hyperprolactinaemia. Hyperprolactinaemia is associated with erectile dysfunction, amenorrhea and reduced bone mineral density (BMD). However, there is insufficient information about the extent, severity and association between these side effects, particularly among the south Indian population.Aim and objectives: To estimate the prevalence of erectile dysfunction and amenorrh...

Introduction: In the year 2010, the Indian Council of Medical Research (ICMR) has published a normative data for mone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) scanning. However, its impact on the diagnosis of osteoporosis when compared to currently used Caucasian database has not been analysed.Objectives: To study the effect of the newly generated ICMR database (ICMRD) on the diagnosis of osteoporosis compared with the Hol...