Endocrine Abstracts

Type 1 diabetes (T1D) is an autoimmune, heterogenous disease caused by immune-mediated destruction of insulin-producing β-cells in the pancreas. The only approved treatment strategies are exogenous insulin replacement therapy and islet transplantation. Leading experimental approaches have focussed on suppression and/or modulation of the immune system. However, efforts to increase β-cell survival are also of great interest. Recent studies in our lab have identified ne...

Adhesion GPCRs (aGPCRs) have been implicated in developmental processes and deletion of some aGPCRs in neonatal mice results in decreased β-cell differentiation capacity, leading to glucose intolerance in adult life. Here, we investigated the expression of aGPCR mRNAs in mouse islets and determined the expression and function of GPR56, the most abundant aGPCR in islets, in developing mouse pancreas. Quantitative PCR indicated that mouse islets expressed mRNAs encoding 26 ...