Endocrine Abstracts

Multiple endocrine neoplasia (MEN) 1 is a rare hereditary autosomal dominant tumor syndrome characterized by two or more endocrine tumors. Non-endocrine neoplasms have been described as well. MEN1 is caused by inactivating mutations of the onco-suppressor gene MEN-1 (chromosome 11q13) which encodes the protein menin. Currently, 897 public variants of MEN-1 gene are reported. We present the case of a recently discovered pathogenic mutations of MEN-1 gene. A 32-year-old Italian ...

Background: Differentiated Thyroid Carcinomas (DTC) represent more than 90% of thyroid tumors with good prognosis and long survival. Currently, patients with intermediate/high risk nodule as assessed by cytological staging may undergo surgery. According to ATA 2017 guidelines, all patients presenting thyroid nodules with suspicious ultrasound features (hypoechoic pattern, irregular margins, microcalcifications, etc.) and cytopathology TIR3B, TIR4 or TIR5 according to 2014-SIAP...