Searchable abstracts of presentations at key conferences in endocrinology

ea0049oc7.4 | Cardiovascular endocrinology (1) | ECE2017

A novel insight into the anticancer mechanism of metformin in Pancreatic Neuroendocrine Tumor cells

Vitali Eleonora , Piccinini Sara , Boemi Ilena , Tresoldi Alberto , Zerbi Alessandro , Carnaghi Carlo , Spada Anna , Lania Andrea

Metformin (1.1-dimethylbiguanide hydrochloride), a widely used antidiabetic drug, has been reported to display potent anticancer properties in various types of cancers, including neuroendocrine tumors. Recently, a potential synergistic activity between metformin and octreotide (SSA) in Pancreatic Neuroendocrine Tumors (P-NETs) has been proposed. AIP (aryl hydrocarbon receptor-interacting protein) acts as tumor suppressor gene in neuroendocrine tumors at pituitary level and it ...

ea0037gp.28.07 | Endocrine tumours and neoplasia – NETS | ECE2015

Complete remission of hepatic metastasis after total gastrectomy for a gastric carcinoid tumor type 1: a case report

Tresoldi Alberto Stefano , Bonifacio Cristina , Pepe Giovanna , Carnaghi Carlo , Lania Andrea Gerardo Antonio

Gastric carcinoids secondary to autoimmune atrophic gastritis (GC type 1) are usually well differentiated neoplasia, with an indolent course and an excellent overall prognosis. However, a subset of these tumors (<5%) may develop advanced disease, with lymph node and/or hepatic metastasis. The pathogenesis of these carcinoids is related to chronic trophic stimuli to enterochromaffin-like (ECL) cells due to chronic hypergastrinemia. Treatments directed to remove the source o...

ea0056gp18 | Adrenal Case reports | ECE2018

Bilateral testicular masses and adrenal insufficiency in a young adult: is congenital adrenal hyperplasia the only possible diagnosis?

Tresoldi Alberto Stefano , Betella Nazarena , Pizzocaro Alessandro , Lania Andrea Gerardo Antonio

Testicular adrenal rest tumours (TARTs) are benign tumours deemed to originate from ectopic adrenal cells that descend with the testes during fetal development. These cells grow under chronic ACTH stimulation, typically in patients with congenital adrenal hyperplasia (CAH). TARTs have also been rarely described in other conditions characterised by chronically elevated ACTH, such as autoimmune primary adrenal insufficiency (PAI). These are benign lesions, but could be misdiagno...

ea0063gp188 | Adrenal and Neuroendocrine - Clinical | ECE2019

Increased risk of infections in Addison’s disease and congenital adrenal hyperplasia patients: a longitudinal study based on a United Kingdom primary care database

Tresoldi Alberto S , Sumilo Dana , Perrins Mary , Toulis Konstantinos A , Prete Alessandro , Reddy Narendra , Wass John A , Nirantharakumar Krishnarajah , Arlt Wiebke

Background: Primary adrenal insufficiency (PAI) can be of autoimmune origin (Addison’s disease, AD) or due to inborn disorders of steroidogenesis (congenital adrenal hyperplasia, CAH). Prognosis of patients with PAI has improved considerably after glucocorticoid replacement therapy became available. However, even in recent years, an increased risk of death has been described in both AD and CAH patients. Moreover, even with the current state-of-the-art replacement therapy,...

ea0063gp236 | Anterior and Posterior Pituitary | ECE2019

Characteristics and natural history of a large cohort of non-functioning pituitary incidentalomas: a two-centers study

Betella Nazarena , Tresoldi Alberto , Carosi Giulia , Sindaco Giulia Del , Locatelli Marco , Mazziotti Gherardo , Milani Davide , Morenghi Elena , Spada Anna , Arosio Maura , Mantovani Giovanna , Lania Andrea

Context: Available data on the natural history of pituitary incidentalomas (PI) are not strong enough to draw any evidence-based conclusion on timing and length of follow up of these masses, due to heterogeneity and low sample sizes.Objective: To describe the characteristics and the natural history of PI using data from a large cohort of patients investigated in two Italian Pituitary Centers.Patients and methods: Retrospective stud...

ea0041gp156 | Pituitary - Clinical | ECE2016

Natural history of a large cohort of pituitary incidentalomas in Italy

Tresoldi Alberto Stefano , Toini Alessandra , Profka Eriselda , Locatelli Marco , Lasio Giovanni Battista , Morenghi Emanuela , Spada Anna , Mantovani Giovanna , Lania Andrea Gerardo

In this observational, retrospective, multicenter study, we analyzed data from 300 patients with pituitary incidentaloma followed in two Italian Hospital Center. We observed a predominance of female patients (65%), with an a mean age at diagnosis of 49 years (higher in men than women, 57 vs 45 years old). The main reason to perform imaging were neurological symptoms not related to the presence of adenomas (56%). Most cases were microadenomas (56%), and macroadenomas were more ...

ea0059cc6 | Featured Clinical Cases | SFEBES2018

What lies beneath: cutaneous Kaposi’s sarcoma as a first manifestation of ectopic ACTH-dependent Cushing’s syndrome

Tresoldi Alberto S , Elhassan Yasir S , Asia Miriam , Elshafie Mona , Lane Peter , Manolopoulos Konstantinos N , Velangi Shireen S , Watkins Steven , Arlt Wiebke , O'Reilly Michael W

Introduction: Immune dysregulation is a feature of Cushing’s syndrome (CS). We report a case of CS that presented with rapidly developing cutaneous Kaposi’s sarcoma (KS).Case description: A previously well 59-year-old heterosexual man presented with a two-month history of proximal muscle weakness, recurrent mouth ulcers, and purplish skin lesions. He had a background history of hypertension. Skin biopsies were compatible with KS. History of pas...

ea0094op1.3 | Neuroendocrinology and Pituitary | SFEBES2023

Biochemical control does not improve functional impairment in people with acromegaly

Z Safdar Nawaz , Heague Megan , Hebden Sophie , Lynch Julie , Mclaren David , Tresoldi Alberto , Lithgow Kirstie , Urwyler Sandrine , Akbar Shahzad , McLoughlin Katie , Kearney Tara , Drake William M. , Sathyapalan Thozhukat , Orme Steve , E Higham Claire , Karavitaki Niki , Kyriakakis Nikolaos , Murray Robert

Acromegaly, a chronic disorder of excessive growth hormone secretion, leads to functional limitation and impaired mobility most commonly due to arthropathy. Patients with biochemically controlled acromegaly have reported persistent impairment in prior studies. We aimed to compare the functional differences in patients with biochemically controlled acromegaly to those with uncontrolled disease by means of validated questionnaires. Between March 2017 and May 2022, patients over ...

ea0094p233 | Neuroendocrinology and Pituitary | SFEBES2023

Characterisation of the Impact of Joint Pain on Patients with Acromegaly

Hebden Sophie , Safdar Nawaz , Heague Megan , Lynch Julie , Mclaren David , Tresoldi Alberto , Lithgow Kirstie , Urwyler Sandrine , Akbar Shahzad , McLoughlin Katie , Kearney Tara , M Drake William , Sathyapalan Thozhukat , Orme Steve , E Higham Claire , Karavitaki Niki , Kyriakakis Nikolaos , Murray Robert

Acromegaly is caused by excessive growth hormone (GH) and insulin-like growth factor (IGF-1) secretion. Arthropathy is a leading cause of morbidity and impaired quality of life in acromegalic patients, often persisting despite therapeutic interventions and biochemical control. This cross-sectional study aimed to characterise the extent and impact of arthropathy in terms of pain and functional impairment. Validated questionnaires, including DASH (Disabilities of the Arm, Should...

ea0094oc3.5 | Neuroendocrinology and Pituitary | SFEBES2023

The effects of biochemical control and Arthropathy on Quality of Life in patients with Acromegaly: a cross-sectional study

Megan Heague , Nawaz Safdar , Sophie Hebden , Julie Lynch , David McLaren , Alberto Tresoldi , Kirstie Lithgow , Sandrine Urwyler , Shahzad Akbar , Katie McLoughlin , Tara Kearney , William M. Drake , Thozhukat Sathyapalan , Steve Orme , Claire E. Higham , Niki Karavitaki , Nikolaos Kyriakakis , Robert D. Murray

One of the most prevalent clinical manifestations of acromegaly is arthropathy which persists despite adequate symptom and biochemical control, and contributes to impaired quality of life. Patients with acromegaly have high psychiatry morbidity and increased prevalence of depression and poor psychological wellbeing. In a large cohort we aim to determine the effects of joint disease and disease control on quality of life in acromegaly. Eighty-five patients (45 women; median age...