Searchable abstracts of presentations at key conferences in endocrinology

ea0090rc9.4 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Dysregulations in CLOCK genes in immune cells in congenital adrenal hyperplasia depending on the type of glucocorticoid replacement regimens

Ju Jing , F. Nowotny Hanna , Tschaidse Lea , Auer Matthias , Reisch Nicole

Background: Glucocorticoid (GC) substitution therapy in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is not able to perfectly mimic physiological circadian profiles. Unphysiologically high doses, as well as unphysiological variations in GC concentrations might cause adverSemetabolic, cardiovascular and immunological effects. Previous publications have demonstrated dysregulations in immune cell profiles of patients with primary adrenal ins...

ea0090p4 | Adrenal and Cardiovascular Endocrinology | ECE2023

Hypogonadism in men with congenital adrenal hyperplasia. A retrospective longitudinal analysis with a special focus on testicular adrenal rest tumors and 11-oxygenated androgens

Auer Matthias , Lottspeich Christian , Bidlingmaier Martin , F. Nowotny Hanna , Tschaidse Lea , Auchus Richard , Reisch Nicole

Background: Hypogonadism is frequent in men with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD). It has recently been demonstrated that testicular adrenal rest tumors (TART) are a source of 11-oxygenated androgens that might impair testicular function, in addition to their local compressive effects. Data on long-term course of testicular function in men with 21OHD and the role of potential influential factors such as presence of TART and 11-oxyge...

ea0090p287 | Adrenal and Cardiovascular Endocrinology | ECE2023

Perception of female patients with congenital adrenal hyperplasia and their parents on genital surgery: a retrospective survey

Tschaidse Lea , Sappl Andrea , Auer Matthias , Lottspeich Christian , Nowotny Hanna F. , Reisch Nicole

Background: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is associated with ACTH-driven adrenal androgen excess. In women with classic CAH, this regularly causes prenatal virilisation of the external genitalia, commonly corrected by genital surgery during the first years of life. This practice, however, has been questioned and is discussed highly controversial. The aim of this study was to retrospectively assess the perspective of affected patients and...

ea0070aep21 | Adrenal and Cardiovascular Endocrinology | ECE2020

Psychosocial determinants of body acceptance and quality of life in women with congenital adrenal hyperplasia

Tschaidse Lea , Quinkler Marcus , Nordenström Anna , Van Der Grinten Hedi Claahsene , Reisch Nicole

Background: Women with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency have a poor Quality of Life (QoL) compared to the general population and are less satisfied with their body appearance. Data indicates that psychosocial determinants such as good professional and general support could be associated with an improved QoL. Since there is only little data available that has been deduced from samples of small size this effect should be further examined....

ea0090rc9.2 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Frequency of stress dose adjustment and adrenal crisis in children and adults with congenital adrenal hyperplasia

Tschaidse Lea , Wimmer Sophie , Auer Matthias , Lottspeich Christian , F. Nowotny Hanna , Dubinski Ilja , Schmidt Heinrich , Quinkler Marcus , Reisch Nicole

Background: Patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) require lifelong glucocorticoid replacement therapy, including stress dose adjustment to prevent life-threatening adrenal crises (AC). Previous studies indicate a high incidence of inadequate stress dose adjustment and AC in patients with CAH. The aim of this study was to prospectively assess AC incidence, frequency and details of stress dose adjustment as well as knowledge of the d...

ea0081oc13.3 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

11-oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing’s disease

Nowotny Hanna , Vogel Frederick , Bidlingmaier Martin , Braun Leah , Reincke Martin , Tschaidse Lea , Auer Matthias , Lottspeich Christian , Hawley James M , Adaway Jo , Keevil Brian , Schilbach Katharina , Reisch Nicole

Background: Symptoms of hyperandrogenism are common in patients with CushingÂ’s disease (CD), but they cannot be sufficiently explained by measured concentrations of circulating androgens. In this study we analyzed the contribution of 11-oxygenated (11o×C19) androgens to hyperandrogenemia in female patients with CD as well as the influence of treatment with steroidogenesis inhibitors osilodrostat and metyrapone on 11o×C19 and classic androgens.<p class="abste...

ea0090p16 | Adrenal and Cardiovascular Endocrinology | ECE2023

Immunophenotypic differences in patients with primary adrenal insufficiency of different etiology

Nowotny Hanna F. , Marchant Seiter Thomas , Ju Jing , Gottschlich Adrian , Schneider Holger , Zopp Stephanie , Vogel Frederick , Tschaidse Lea , Auer Matthias , Lottspeich Christian , Kobold Sebastian , Rothenfuszer Simon , Beuschlein Felix , Reincke Martin , Braun Leah , Reisch Nicole

Background: Primary adrenal insufficiency (PAI) has been associated with increased risk of infection, adrenal crises and a higher mortality rate. This is caused by altered circadian cortisol profiles, which ultimately lead to immune cell dysregulation. In this study, we aim to characterize differences in immunophenotype of PAI patients of three different etiologies.Methods: Cross-sectional single center study including 28 patients with congenital adrenal...

ea0081rc2.7 | Rapid Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Improved biochemical control with modified-release hydrocortisone overturns the impaired fludrocortisone effect in salt-wasting CAH patients

Tschaidse Lea , Reisch Nicole , Arlt Wiebke , Brac De La Perriere Aude , Linden Hirschberg Angelica , Juul Anders , Mallappa Ashwini , Merke Deborah P , Newell-Price John DC , Perry Colin Graham , Prete Alessandro , Rees Aled , Stikkelbroeck Monica , Touraine Phillippe A , Coope Helen , Porter John , Ross Richard John M , Quinkler Marcus

Background: Patients with salt-wasting congenital adrenal hyperplasia (CAH) due to classic 21-hydroxylase deficiency require glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy. Recently, it was shown that twice daily modified-release hydrocortisone hard capsules (MRHC, Efmody®, Diurnal Ltd) improved control of CAH with most patients showing good disease control versus standard GC therapy. However, no data has been reported on the renin-angiotens...

ea0081rc2.8 | Rapid Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Fertility in congenital adrenal hyperplasia (CAH) patients on modified release hydrocortisone capsules (MRHC, Efmody)

Tschaidse Lea , Quinkler Marcus , Arlt Wiebke , Brac De La Perriere Aude , Linden Hirschberg Angelica , Juul Anders , Mallappa Ashwini , Merke Deborah P , Newell-Price John DC , Perry Colin Graham , Prete Alessandro , Rees Aled , Stikkelbroeck Monica , Touraine Philippe A , Coope Helen , Porter John , Ross Richard John M , Reisch Nicole

Background: Fertility in CAH women is impaired: 0.25 live births vs 1.8 in the UK population and 45% have irregular menses vs 13.6% in healthy women1. Male fertility is also impaired in CAH with oligospermia reported in 48%2. Treatment of infertility usually involves increasing the glucocorticoid dose to normalise adrenal androgens and progesterone to facilitate ovulation and implantation, respectively. Modified-release hydrocortisone (MRHC) capsules, (Ef...