Endocrine Abstracts

Background: Hormonal activity and insulin resistance (IR) in patients with incidentally discovered bilateral adrenal adenomas (BA) has not been evaluated until now. Therefore, we have investigated cortisol and aldosterone secretion and IR in 29 patients with BA, in 113 patients with unilateral adrenal adenomas (UA) and in 89 healthy subjects (C).Methods: All subjects underwent the following investigation: 1) Low dose dexamethasone suppression test (LDDST...

Introduction: Adrenal incidentalomas (AI) with or without concomitant autonomous cortisol secretion can be associated with several metabolic alterations that may lead to increased cardiovascular risk. However, data regarding insulin resistance (IR) during long term follow-up of AI are scarce. The aim was to prospectively investigate the presence and evolution of IR in patients with AI between 2003 and 2014.Methods: Seventy three patients with AI for at l...

Introduction: Acromegaly is well known to induce hypertrophy and hyperplasia in many organs, i.e. thyroid gland, colon, prostate. This action is presumably exerted by the elevated GH and IGF1 levels. In our study, we investigated the alterations of the adrenal glands seen in acromegaly.Aim: To assess the changes in adrenal morphology and functional status in a series of patients with acromegaly.Subjects and methods: Fifty-four acro...

Introduction: The prevalence of autonomous aldosterone secretion (AAS) in hypertensive subjects varies due to the use of various suppression tests and cut-off values. Our aim was to evaluate the prevalence of AAS in hypertensive subjects and test the anti-hypertensive effect of targeted treatment of the renin angiotensin II aldosterone system (RAAS) in AAS subjects.Description of methods/design: We investigated 336 hypertensive subjects with and without ...

Introduction: Primary aldosteronism (PA), the most common endocrine cause of secondary hypertension, is generally underdiagnosed using current diagnostic tests.Aim: To present our 14-year experience of prospective studies on the diagnosis, prevalence and treatment of PA.Patients and methods: We studied 992 hypertensive patients and 278 age-, sex- and body mass index – matched controls (194 normotensive and 104 with essential h...