Searchable abstracts of presentations at key conferences in endocrinology

ea0024p52 | (1) | BSPED2010

UK trends in the treatment of young patients with thyrotoxicosis using radioiodine

Turner N , Driver I , Cheetham T

Background: Radioiodine (RI) treatment of benign thyroid disease in young people has received a lot of attention recently with authorities in the US highlighting an encouraging short and medium term safety record. In this audit we surveyed treatment centres in the UK to assess the trend in RI administration in patients aged 21 years and under.Methods: Over sixty Medical Physics Departments, dispersed to represent a suitable geographical coverage pattern ...

ea0005p202 | Reproduction | BES2003

Complications of testosterone replacement in men with primary and secondary hypogonadism

Meston N , Turner H , Wass J

IntroductionTestosterone replacement for hypogonadism comes in a variety of galenical forms. Side effects include prostatic enlargement and polycythaemia. Furthermore careful scrutiny for prostatic carcinoma is essential. We audited 205 male patients from one clinical centre to assess dose, frequency and complications profile and the effectiveness of biochemical and haematological monitoring. Data of this type in a group of this size has not been previously published.M...

ea0011p439 | Endocrine tumours and neoplasia | ECE2006

Hyperprolactinaemia in a series of adults with craniopharyngiomas and Rathke’s cleft cysts: what are the upper limits?

Thanabalasingham G , Karavitaki N , Meston N , Turner HE , Wass JAH

Introduction: Disruption of the hypothalamic dopaminergic inhibitory control of prolactin (PRL) secretion results in hyperprolactinaemia. We have previously shown in a large series of patients with non-functioning pituitary macroadenomas that serum PRL virtually never exceeds 2000 mU/l in the absence of PRL elevating medications. Current data on the effect of other sellar/parasellar masses are limited.Objective: To investigate the range of PRL values at ...

ea0008p63 | Neuroendocrinology and behaviour | SFE2004

Serum prolactin levels in patients with non-functioning pituitary adenomas and craniopharyngiomas

Shore HCA , Karavitaki N , Meston N , Turner HE , Wass JAH

Background: Pituitary stalk compression by sellar/parasellar tumours [commonly non-functioning pituitary adenomas (NFA) or craniopharyngiomas (CR)] is one of the causes of hyperprolactinaemia. However, in such cases the upper limits of serum prolactin (PRL) are not clearly defined ('grey zone': 3000-6000 mU/L) causing confusion in the differential diagnosis between disconnection hyperprolactinaemia and prolactin-secreting adenomas.Objective: To investiga...

ea0007p159 | Neuroendocrinology and behaviour | BES2004

Imaging of the pituitary is indicated in marginal hyperprolactinaemia (<1000 milliunits per litre) to detect microadenoma

Shore H , Karavitaki N , Turner H , Wass J

Background: In clinical practice there is considerable confusion as to whether pituitary imaging is indicated in patients presenting with a marginally elevated serum prolactin level (<1000 milliunits per litre) and no other discernible cause of hyperprolactinaemia.Objective: The aim of this study was to investigate the frequency of radiological abnormalities of the pituitary in patients presenting with marginal hyperprolactinaemia (<1000 milliunits...

ea0086p122 | Reproductive Endocrinology | SFEBES2022

Are elevated red blood cell parameters coincidental or correlated in patients with Turner syndrome?

D S A Dilrukshi M , Beck K , Roy N , Turner H E

Introduction: Long-term increased morbidity and mortality in Turner Syndrome (TS) due to vascular disease is recognized, and suggested risk factors include metabolic parameters and possible change in haemostasis, however elevated red cell parameters in women with TS have not previously been noted.Methods: Following an observation of unexplained occurrence of elevated hemoglobin, a quality improvement-project was conducted to retrospectively review full b...

ea0011p549 | Endocrine tumours and neoplasia | ECE2006

Diagnostic utility of dexamethazone suppression tests in the work-up of Cushing’s disease

Roderick EJ , Collison K , Karavitaki N , Turner HE , Suliman S , Wass JAH

Background: Cushing’s disease (CD) may be associated with equivocal results on biochemical investigations.Aim: To evaluate the usefulness of dexamethazone suppression tests in the diagnostic work-up of CD.Patients and methods: Seventy patients with CD [median age 38 yrs(16–76), 53 females] presenting between 1976–2005 were studied. 24-hr urinary free cortisol (UFC), overnight (oDST) (1 mg at 23:00 h), low dose (LDDST...