Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp51 | Bone & Calcium Homeostasis 2 | ECE2017

Calcium to phosphorous ratio (Ca/P) as helpful index to recognize primary hyperparathyroidism, but not primary hypoparathyroidism: a big-data approach

Vincentis Sara De , Santi Daniele , Rochira Vincenzo , Setti Monica , Tagliavini Simonetta , Varani Manuela , Trenti Tommaso , Simoni Manuela , Madeo Bruno

Background: Primary hyperparathyroidism (HyperPT) and primary hypoparathyroidism (HypoPT) are often underdiagnosed. Several strategies have been investigated in the past in order to identify diagnostic parameters, although the diagnosis of both HyperPT and HypoPT remains challenging so far, especially in asymptomatic patients. Calcium (Ca) and phosphorus (P) are inversely related together, thus the Ca/P ratio could be an useful tool to define these conditions. Recently, we pro...

ea0090oc2.1 | Oral Communications 2: Thyroid | ECE2023

Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy: The levolio study

Brigante Giulia , Santi Daniele , Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Roy Neena , Casarini Livio , Trenti Tommaso , Varani Manuela , De Santis Maria Cristina , Roli Laura , Rochira Vincenzo , Simoni Manuela

Introduction: Despite normal thyroid-stimulating hormone serum levels, up to 60% of hypothyroid patients are dissatisfied with the treatment. Animal studies suggest that the persistence of symptoms may derive from peripheral hypothyroidism. Combination treatment with levothyroxine and liothyronine is a theoretically plausible solution but its efficacy is still questionable.Aim: To evaluate the effects of personalized twice-daily combination therapy on pe...

ea0049ep1123 | Female Reproduction | ECE2017

Heterogeneous hCG and hMG commercial preparations result in biased intracellular signaling but induce similar progesterone response in vitro

Riccetti Laura , Klett Daniele , Ayoub Mohammed Akli , Boulo Thomas , Mariot Julie , Pignatti Elisa , Tagliavini Simonetta , Varani Manuela , Tranti Tommaso , Nicoli Alessia , Sala Giovanni Battista La , Combarnous Yves , Reiter Eric , Simoni Manuela , Casarini Livio

Human chorionic gonadotropin (hCG) is the pregnancy hormone marketed as a drug for assisted reproduction technologies to support follicle-stimulating hormone action. Several hCG formulations are commercially available, differing in source, purification methods and biochemical composition. In this study, we investigated the molecular features and the intracellular signaling mediated by five urinary and recombinant hCGs. The drug comparisons were performed by quantifying the hor...