ea0099ep1306 | Late Breaking | ECE2024
Aghajanova Yelena
, Melkonyan Arthur
, Alchujyan Nina
, Gayane Bayburdyan
, Arakelyan Lusine
, Hakobyan Sona
, Gevorgyan Zara
, Zohrabyan Naira
, Hovhannisyan Margarita
, Mnatsakanyan Armine
, Vardanyan Anna
Introduction: Type 1 diabetes (T1DM) is one of the most frequent autoimmune and metabolic disorders in childhood and youth, developing due to autoimmune destruction of β-cells, which leads to an absolute insulin deficiency. Accumulating data suggest that gut microbiota (GM) may contribute to the pathogenesis of diabetes influencing the immune response, in which arginine-metabolizing enzymes are involved, particularly arginase. We examined the connection between GM and cyt...