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ea0016p547 | Obesity | ECE2008

Central resistin regulates both hypothalamic and peripheral lipid metabolism in a nutritional dependent fashion

Vazquez MJ , Gonzalez CR , Varela L , Lage R , Tovar SA , Sangiao-Alvarellos S , Williams LM , Vidal-Puig A , Nogueiras R , Lopez M , Dieguez C

Current evidence suggests that the adipocyte-derived hormone resistin (RSTN) regulates both feeding and peripheral metabolism through unclear hypothalamic-mediated mechanisms. Here, we demonstrate by the first time, that the anorectic effect of RSTN is associated to specific changes in the expression of neuropeptides in the arcuate nucleus of the hypothalamus (ARC), namely AgRP, NPY and CART. Very interestingly, RSTN also exerts a deep, nutritional-dependent inhibitory effect ...

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ea0029p1564 | Thyroid (non-cancer) | ICEECE2012

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism

Sanchez N Martinez , Varela L. , Martins L. , de Morentin P Martinez , Gallego R. , Vazquez M. , Roa J. , Gandara M. , Schoenmakers E. , Nogueiras R. , Chatterjee K. , Sempere M. Tena , Dieguez C. , Lopez M.

Hyperthyroid rats and humans exhibit increased energy expenditure and marked hyperphagia. Recent evidence has pointed that alterations of thermogenesis linked to hyperthyroidism are associated to dysregulation of hypothalamic AMPK and fatty acid metabolism; however, the central mechanisms mediating hyperthyroidism-induced hyperphagia remain largely unclear.Objective: The aim of our study was to assess if alterations in feeding in hyperthyroidism are asso...

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Endocrine Abstracts

Central resistin regulates both hypothalamic and peripheral lipid metabolism in a nutritional dependent fashion

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism

BiosciAbstracts