Searchable abstracts of presentations at key conferences in endocrinology

ea0011p241 | Cytokines and growth factors | ECE2006

Effect of growth hormone deficiency in adults on insulin action and gene expression of selected adipokines in subcutaneous adipose tissue

Penesova A , Skopkova M , Pura M , Vlcek M , Radikova Z , Vorzakova I , Tajtakova M , Vanuga P , Belan V , Koska J , Payer J , Klimes I , Gasperikova D

Growth hormone deficiency (GHD) in adults seems to predispose to insulin resistance (IR). Development of GHD related IR could be associated with adipose tissue (AT) derived signals. To investigate the nature of this pathological regulation we 1) measured gene expressions for leptin, adiponectin, TNFalpha, IL-6, 11beta HSD1, SREBP, PPARgamma in the AT of untreated GHD adults, and 2) assessed effect of euglycemic hyperinsulinemia (HI) at the gene level.Met...

ea0029p332 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Sympathetic over-activity and low adrenocortical responses to hypoglycemia in patients in early stage of hypertension

Penesova A. , Radikova Z. , Cizmarova E. , Kvetnansky R. , Vlcek M. , Imrich R.

Increased activity of sympathetic nervous system (SNS) was observed in early stage of hypertension onset. The aim of our present study was to estimate catecholamines response to stress stimulus (insulin induced hypoglycaemia) in young males with early diagnosed non-treated hypertension grade 1 (HT) and normotensive controls (NT).Methods: Insulin tolerance test (ITT, 0.1 IU/kg body weight, Actrapid HM, i.v.) was performed in 21 HT male subjects aged 20.0&...

ea0029p1196 | Obesity | ICEECE2012

Prediabetes in adult GH deficiency is associated with a substantial reduction in serum and adipose tissue expression levels of zinc-α2-glycoprotein

Balaz M. , Ukropcova B. , Kurdiova T. , Penesova A. , Skyba P. , Vlcek M. , Belan V. , Klimes I. , Payer J. , Imrich R. , Smith S. , Tkacova R. , Gasperikova D. , Ukropec J.

Adult GH deficiency (GHD) is associated with prediabetes and low levels of GH are found in obesity. We hypothesized that zinc-α2-glycoprotein (ZAG), a novel adipokine reduced in obesity, is regulated by GH. ZAG serum and adipose tissue expression were measured in three study populations: i) cachectic (BMI=19.3±0.5 kg/m2), lean/overweight (BMI=26.0±0.5 kg/m2) and obese (BMI=36.0±1.6 kg/m2) patients with chronic obstructive pu...