Endocrine Abstracts

The secretion of growth hormone (GH) is under the feedback control of numerous nutritional and endocrine factors. The most widely used endocrine dynamic tests used to diagnose GH deficiency, insulin hypoglycemia test, and glucagon test, are time-consuming and cumbersome both for patients and medical personnel. There is an unmet need for easier to conduct, shorter, and safer diagnostic tests. We and other groups have previously demonstrated that acute administration of glucagon...

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a popular tool for the treatment of type 2 diabetes. Unlike many other antidiabetic drug classes, distinct GLP-1 RAs have different therapeutic profiles, mostly due to their different pharmacokinetic properties. Animal experiments and human data indicate that tolerance develops toward at least some of their effects, e.g., gastric motility. Whether tolerance develops toward the glucose-lowering effect...

Background: Cushing’s syndrome (CS) is estimated to have a 10-fold increased risk of venous thromboembolism (VTE) compared with the normal population with VTE accounting for 3.6-11% deaths in CS patients. There are no specific guidelines for VTE prophylaxis in CS other than that it should be considered given the increasingly recognised risk.Methods: Via the Society for Endocrinology, we surveyed current VTE anticoagulation practice across UK Endocri...

For all ERCUSYN investigatorsBackground: Patients with Cushing’s syndrome (CS) have an increased risk of developing venous thromboembolic complications. There is currently no standard practise for thromboprophylaxis in CS patients.Aim: To study the details of VTE in patients included in The European Registry on Cushing’s syndrome (ERCUSYN) and study various thromboprophylaxis protocols used among the centres where VTE&#14...