Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep792 | Endocrine tumours and neoplasia | ECE2017

Chronic stress and somatotroph axis in breast cancer more than a simple association

Crumpei Iulia , Armasu Ioana , Danciu Mihai , Tofan Mariana , Volovat Constantin , Belceanu Alina , Crumpei Felicia , Adomnicai Valentina , Vulpoi Carmen

Introduction: Epidemiological and clinical studies have proven direct correlations between chronic stress, inflammation and cancer progression. The inflammatory environment preexisting the malignant change and elevated IGF-1 levels are associated with higher cancer risk, especially through GH effects on cell proliferation and inhibition of apoptosis.Aim: To evaluate the relationship between biological and hormonal stress markers, growth factors and breas...

ea0049ep809 | Obesity | ECE2017

Obesity, gonadotropic axis and breast cancer – is ghrelin the connexion?

Armasu Ioana , Crumpei Iulia , Volovat Constantin , Tofan Mariana , Zaharia Valentin , Aancutei Adrian , Vasiliu Ioana , Lacramioara Serban Ionela , Vulpoi Carmen

Introduction: Obesity and insulin resistance have been identified as risk factors for breast cancer and are associated with late-stage diagnosis and poor prognosis. Ghrelin is a unique gut-derived peptide that has major impact in energy homeostasis and weight regulation, with new emerging implications in tumorigenesis process, especially in hormone-dependent cancers.Aim: To evaluate the relationship between ghrelin, clinico-biological parameters of obesi...

ea0037ep81 | Adrenal cortex | ECE2015

Acute adrenal insufficiency as a first sign of metastatic pulmonary carcinoma

Manolachie Adina , Volovat Constantin , Grigorescu Cristina , Botnariu Gina Eosefina , Gafton Bogdan , Armasu Ioana , Leustean Letitia , Vulpoi Carmen

Introduction: Adrenal glands are common sites for secondary lesions derived from malignant tumours (lymphoma, melanoma, renal, breast, colon, and bronchopulmonary cancer). Patients with adrenal secondary lesions are typically asymptomatic but 1% may present with adrenal insufficiency as a first manifestation. We report the cases of two males with lung adenocarcinoma, first presented with acute adrenal insufficiency.Cases presentation: Case 1: LC, 65 year...

ea0037ep1343 | Clinical Cases–Thyroid/Other | ECE2015

Concomitance of pancreatic and neuroendocrine breast tumour – simple coincidence or not?

Crumpei Iulia , Fadur Alina , Manolachie Adina , Zmau George , Anton Mihaela , Volovat Constantin , Ungureanu Maria Christina , Vulpoi Carmen

Introduction: Breast neuroendocrine carcinoma is a rare aggressive neuroendocrine tumour (NET) and the research on this subject is poor. Only seven studies were cited in the literature. Incidence in the population has not been reported, but the prevalence is under 0.1% of all breast carcinomas.Case report: AV, 72, is hospitalised for bone pain and significant weight loss (15 kg in 2 months). PatientÂ’s previous history are: diabetes, hypertension, no...

ea0035p592 | Endocrine tumours and neoplasia | ECE2014

Pancreatic neuroendocrine tumour with a silent long evolution: case report

Manolachie Adina , Crumpei Felicia , Volovat Constantin , Bodescu Ioana , Idriceanu Jeanina , Vasiliu Ioana , Fadur Alina , Preda Cristina , Vulpoi Carmen

Pancreatic neuroendocrine tumors (pNET) represent 1.3% of pancreatic tumours, ~65% patients presenting with metastatic/unresectable disease. Clinically, pNET may be asymptomatic, accompanied by carcinoid syndrome or abdominal pain.Patient N.A. aged 73, with a history of hemorrhagic pancreatitis, was diagnosed in 2003 with a hyperechoic heterogeneous solid pancreatic tumour of 28/28 mm. No therapy/monitoring were proposed. After 7 years of asymptomatic ev...

ea0037ep626 | Obesity and cardiovascular endocrinology | ECE2015

Obesity and breast cancer – does size matter?

Armasu Ioana , Crumpei Iulia , Volovat Constantin , Belceanu Alina Daniela , Constantinescu Georgiana Andreea , Tofan Mariana , Ungureanu Maria Christina , Leustean Letitia , Vulpoi Carmen

Introduction: The epidemic of obesity has risen many health concerns, beneath the metabolic syndrome. One of these problems is the effect of obesity on cancer evolution. Populational studies have shown a direct correlation of BMI with worse prognostic, life quality and occurrence of comorbidities in neoplastic diseases, one of the most studied being breast cancer.Patients and methods: We retrospectively analysed the evolution of postmenopausal obese and ...