Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc1.7 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

The role of chemokines in type 1 diabetes-associated neuropathy

Baldimtsi Evangelia , Papadopoulou-Marketou Nektaria , Jenmalm Maria , Wahlberg Jeanette

Background and aims: Diabetic neuropathy is a common complication in patients with type 1 diabetes mellitus (T1D). In this study, we explore the importance of circulating chemokines for the development of diabetic neuropathy (DN) in T1D.Materials and methods: This study was a cross-sectional analysis of patients with childhood onset T1D followed prospectively in a long-term longitudinal cohort study. Fifty-two patients (20 women/32 men; mean age 28 &#177...

ea0081rc10.4 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Adequate metabolic control at early stages of childhood onset type 1 diabetes prevent diabetic neuropathy: a 30 year follow up study

Baldimtsi Evangelia , Amezcua Salvador , Olausson Hakan , Ludvigsson Johnny , Hyllienmark Lars , Wahlberg Jeanette

Background and aims: Diabetic neuropathy is a common complication of type 1 diabetes. In this study we investigated the importance of long-term metabolic control for the development of diabetic neuropathy in patients with type 1 diabetes diagnosed in childhood.Materials and methods: Longitudinal cohort study. Twenty-five patients (9 women 16 men) were studied three times with neurophysiological measurements and clinical examinations. At baseline the pati...

ea0037ep71 | Adrenal cortex | ECE2015

Fludrocortisone therapy in patients with primary adrenal insufficiency: relationships with different hydrocortisone doses

Ekman Bertil , Quinkler Marcus , Jones Beverly A , Marelli Claudio , Murray Robert , Zelissen Pierre , Wahlberg Jeanette

Introduction: During recent years many authors have advocated lower hydrocortisone doses in patients with primary adrenal insufficiency (PAI) mainly due to worries for non-physiological effects like increased cardiovascular risk and bone resorption, but very little attention has been drawn to fludrocortisone dosing. Our main hypothesis was that that the higher hydrocortisone dose, the lower the fludrocortisone dose and vice versa.Design: The Eur...

ea0099p425 | Adrenal and Cardiovascular Endocrinology | ECE2024

Income and work loss in patients with Addison’s disease in Sweden: A nationwide population-based study

Stergianos Stavros , Everhov Asa Hallqvist , Soderling Jonas , Bergthorsdottir Ragnhildur , Wahlberg Jeanette , Kampe Olle , Skov Jakob , Bensing Sophie

Background: Previous studies have found reduced health-related quality of life and employability in patients with autoimmune Addison’s disease (AAD). However, there are no large studies examining the economic cost of illness for the individual.Objective: To study differences in income and work loss between patients with AAD and matched comparators.Methods: In this cross-sectional study we linked the Swedish Addison Register an...

ea0041gp14 | Adrenal (1) | ECE2016

A Phase 3b, open-label, extension study to evaluate the long-term safety of once-daily, dual-release hydrocortisone (DR-HC) in patients with adrenal insufficiency (AI)

Nilsson Anna , Bergthorsdottir Ragnhildur , Burman Pia , Dahlqvist Per , Ekman Bertil , Eden Engstrom Britt , Ragnarsson Oskar , Skrtic Stanko , Wahlberg Jeanette , Achenbach Heinrich , Uddin Sharif , Marelli Claudio , Johannsson Gudmundur

Introduction: Glucocorticoid replacement for adrenal insufficiency (AI) remains inadequate, resulting in high morbidity, premature mortality and quality-of-life (QoL) impairment. This study investigated the long-term safety of dual-release hydrocortisone (DR-HC) in patients with primary AI.Methods: AI patients who completed a randomized, 3-month crossover study of once-daily DR-HC versus thrice-daily conventional immediate-release hydrocortisone plus a 6...

ea0070aep597 | Pituitary and Neuroendocrinology | ECE2020

High usage of drugs for neuropsychiatric morbidity in patients with Cushing´s disease before diagnosis and at 5–10 years follow-up – a nationwide study

Bengtsson Daniel , Ragnarsson Oskar , Berinder Katarina , Dahlqvist Per , Edén Engström Britt , Ekman Bertil , Höybye Charlotte , Wahlberg Jeanette , Burman Pia

Background: Neuropsychiatric symptoms and cognitive dysfunction are common in Cushing´s disease (CD), and seem only partly reversible after biochemical remission has been achieved.Aim: To investigate prescription of drugs associated with neuropsychiatric morbidity in a large national cohort of CD patients.Methods: Patients in the Swedish Pituitary Registry, diagnosed with CD between July 2006 and January 2018 were included, <e...

ea0056gp29 | Adrenal clinical | ECE2018

Salivary cortisol and cortisone in Cushing diagnosis – reference ranges and clinical cut off limits

Backlund Nils , Brattsand Goran , Israelsson Marlen , Ragnarsson Oskar , Burman Pia , Engstrom Britt Eden , Hoybye Charlotte , Berinder Katarina , Wahlberg Jeanette , Dahlqvist Per

Introduction: Cushing’s syndrome is rare, but assessment of patients with clinical suspicion of Cushing’s and/or adrenal incidentaloma is frequently required. Thus, there is a need for biochemical screening methods that with high sensitivity and specificity identifies or rule out hypercortisolism. Analysis of late night salivary cortisol allows an easy sampling procedure performed at home and is independent of variations in plasma CBG levels. Analysis by liquid chrom...

ea0099p179 | Late-Breaking | ECE2024

Mortality in young women with turner syndrome is mainly due to aortic dissection - a 25-year follow-up in sweden

Thunstrom Sofia , Thunstrom Erik , Naessen Sabine , Berntorp Kerstin , Kitlinski Margareta , Ekman Bertil , Wahlberg Jeanette , Bergstrom Ingrid , Isaksson Magnus , Basic Carmen , Svanvik Teresia , Bryman Inger , Landin-Wilhelmsen Kerstin

Context: Turner syndrome (TS) is the most common sex chromosome aberration, affecting 1/2500 born girls. Reduced life expectancy has been reported.Objective: The objective was to investigate the causes of mortality and identify the risk factors that contribute to death in women with TS.Design and setting: A matched retrospective observational study of women with TS from the Turner centers in Sweden was conducted. Echocardiography w...

ea0081p10 | Adrenal and Cardiovascular Endocrinology | ECE2022

Comparison of assays for salivary cortisol and cortisone in the diagnosis of Cushing’s syndrome

Backlund Nils , Brattsand Goran , Lundstedt Staffan , Aardal Elisabeth , Bartuseviciene Inga , Katarina Berinder , Burman Pia , Eden Engstrom Britt , Hoybye Charlotte , Isaksson Anders , Ragnarsson Oskar , Ruetschi Ulrika , Wahlberg Jeanette , Olsson Tommy , Dahlqvist Per

Background & Objective: Late night salivary cortisol (LNSC) and 1 mg overnight dexamethasone suppression test (DST) are two of the three recommended screening tests for Cushing’s syndrome (CS). The classical DST uses serum cortisol, but analysis of salivary cortisol and cortisone has shown high diagnostic accuracy at DST (1). Salivary cortisol can be analysed with immunoassays, which suffer from variable degree of cross reactivity with other steroids, or with LC-MS/MS...

ea0041gp167 | Pituitary - Clinical (1) | ECE2016

Sleep apnea in patients with acromegaly – prevalence, diagnosis and risk factors

Vouzouneraki Konstantina , Franklin Karl , Forsgren Maria , Warn Maria , Tiberg Jenny , Wik Helena , Dahlgren Christina , Alkebro Caroline , Nilsson Ann-Sofie , AEkerman Anna-Karin , Burman Pia , Hoybye Charlotte , Ragnarsson Oskar , Wahlberg Jeanette , Engstrom Britt Eden , Dahlqvist Per

Introduction: Patients with acromegaly have an increased mortality, mainly due to cardiovascular and respiratory diseases. Sleep apnea is related to hypertension, stroke and cardiovascular diseases and is reported to occur in 11–30% of acromegaly patients, according to retrospective studies based on diagnostic ICD-codes. However, in smaller prospective studies sleep apnea is found in about 70% of patients with active acromegaly and 40% after biochemical control. This diff...