Endocrine Abstracts

Background: Arguably patients undergoing total thyroidectomy for papillary thyroid cancers (PTC) are more likely to have negative radioactive iodine uptake and low/undetectable thyroglobulin levels if the central compartment lymph node dissection (CCLND) is performed routinely irrespective of the macroscopic appearance of the LN. The aim of this study was to determine whether routine CCLND leads to more favourable outcome in the first year after treatment for well-differentiat...

We present the case of a 51-year-old woman who attends the NET service at the Oxford University Hospitals Trust with multiple known secretory paragangliomas (predominantly 3-methoxythyramine), including a carotid body tumour and, most recently, an intrapericardial paraganglioma. She is SDHC mutation positive. Multiple surgical resections of paragangliomas, at sites other than the cardiac lesion, had previously been undertaken. Due to disease progression and symptomati...

Background: Overt and subclinical hypothyroidisms are associated with altered cerebral blood flow (CBF) which may be reversed with levothyroxine treatment (T4T). Subclinical hypothyroidism (SCH) is associated with fatigue but it is unclear whether fatigue is related to abnormal CBF and whether T4T has a beneficial impact. We therefore studied fatigued SCH patients before and after T4T and euthyroid non-fatigued healthy controls (HC).Methods: CBF was meas...

Gallium68-Dotatate PET-CT is a somatostatin-receptor (SSTR) based imaging modality employed in the diagnosis and follow-up of Neuroendocrine Tumours (NET). We set out to investigate the incidence of incidental findings, some of which are related to SSTR expression, in our NET patient cohort in Oxford University Hospital. Sixty-eight patients underwent Gallium68-Dotatate PET-CT between June 2020 and June 2021. 40 patients (59%) were female, and median age ...

We present the case of a 54-year-old woman with known metastatic non-functional pancreatic NET since 2004 that developed new debilitating recurrent hypoglycemia in 2013. The patient presented in 2004 with disseminated malignancy. Radiology revealed a large pancreatic mass associated with multiple liver lesions and abdominal lymphadenopathy. Liver biopsy confirmed well differentiated NET. Initial treatment with cisplatin etoposide chemotherapy was poorly tolerated and discontin...

We report a retrospective, single centre observational study to determine the characteristics and outcomes of pancreatic insulinoma. Interrogation of the Oxford NET database, a departmental database of new NET MDT referrals since 2011 (n = 1059), revealed 23/1059 (2.1%) patients with insulinoma diagnosed and treated between 2011 and 2018. Patient records were reviewed and data was captured on demographics, presentation, investigations, treatments and outcomes: 15/23 (...

Neuroendocrine tumours (NETs) presenting as metastatic cancer of unknown primary site (CUP) are suspected to confer poorer prognosis compared to metastatic NETs of known primary site. We performed a retrospective, single centre study to determine the prognostic indicators in CUP-NETs compared to metastatic small intestinal NET (SiNET), before and after adjusting for factors known to affect overall survival. Subjects were selected from a departmental database of 1050 NET patien...