Searchable abstracts of presentations at key conferences in endocrinology

ea0021p182 | Diabetes and metabolism | SFEBES2009

Deficiency in 11β-hydroxysteroid dehydrogenase type 1 reduces systemic inflammation and inflammatory cell infiltration in atherosclerotic lesions of ApoE−/− mice

Kipari Tiina , Man Tak-Yung , Hadoke Patrick , White Christopher , Chapman Karen , Seckl Jonathan

High plasma levels of glucocorticoids cause metabolic disease (central obesity, hypertension, diabetes) and increase risk of cardiovascular disease. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates glucocorticoids in intact cells, converting inert cortisone (11-dehydrocorticosterone in rodents) into active cortisol (corticosterone in rodents). Recent work has shown the pathological importance of elevated adipose tissue 11β-HSD1 expression in develo...

ea0038p230 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Maternal overnutrition programs hypothalamic neuropeptides and metabolic syndrome in offspring

Ramamoorthy Thanuja Gali , Allen Tiffany-Jayne , Davies Alison , Harno Erika , Sefton Charlotte , Wray Jonathan , Murgatroyd Christopher , White Anne

Background and objective: The prevalence of obesity is increasing worldwide and it is known that intra-uterine experience can program metabolic disorders. The hypothalamic appetite regulatory system is a key target of developmental programming by maternal nutrition. Therefore, the aim of this study was to investigate the effects of maternal overnutrition on the expression of hypothalamic genes controlling energy homeostasis.Research design: Eight week ol...

ea0035p748 | Obesity | ECE2014

Bariatric surgery and bone loss: novel mechanisms and comparison of different modalities

Brzozowska Malgorzata , Bliuc Dana , Hong Angel , Jorgensen John , Talbot Michael , Rigas Georgia , Chen Weiwen , Pocock Nicholas , Eisman John , White Christopher , Baldock Paul , Center Jacqueline

Although bariatric surgery is the most effective weight loss therapy, its skeletal consequences are unclear. The aim of this study was to assess the impact of weight loss, gut hormones, adiponectin on bone loss in people undergoing Dieting (Diet), Gastric Banding (GB) and Gastric Sleeve (GS) over 24 months post-intervention.There were 15 Diet, 8 GB and 20 GS subjects with mean (±S.D.) age 53 (12) years and BMI 39 (6). At 12 months mea...