Searchable abstracts of presentations at key conferences in endocrinology

ea0032oc5.2 | Reproduction | ECE2013

The (TAAAA)n polymorphism in the SHBG gene is related to prenatal androgenization of female fetus: possible implications of the developmental origin of metabolic disorders

Pamporaki Christina , Xita Nectaria , Lazaros Leandros , Makridimas George , Georgiou Ioannis , kolios George , Plachouras Nikolaos , Tsatsoulis Agathocles

Introduction: The aim of this study was to examine whether the distribution of SHBG (TAAAA)n repeat variants contributes to the exposure of the female fetus to androgen excess, by influencing the, in utero, androgen availability.Methods: The study population consisted of 100 pregnant women that carried female fetuses and underwent the procedure of amniocentesis due to age (older than 35). Blood samples and amniotic fluid samples were dr...

ea0016p638 | Reproduction | ECE2008

The importance of the (TTTA)n polymorphism of aromatase (CYP19) gene in menarche

Xita Nectaria , Chatzikyriakidou Anthoula , Stavrou Ioanna , Zois Chris , Georgiou Ioannis , Tsatsoulis Agathocles

Background of study: Twin studies have shown that age at menarche may be subject to hereditary influences but the specific determinants are unknown. Estrogens are known to have an important role in menarche. Since aromatase is responsible enzyme for the conversion of androgens to estrogens, the aromatase (CYP19) gene could be a candidate gene for the regulation of menarche. The aim of this study was to investigate the possible association of the CYP19(TTTA)n poly...

ea0016p640 | Reproduction | ECE2008

The role of sex hormone-binding globulin (SHBG) and aromatase (CYP19) gene variants in the development of polycystic ovary syndrome (PCOS)

Xita Nectaria , Lazaros Leandros , Georgiou Ioannis , Psofaki Vasiliki , Kolios George , Tsatsoulis Agathocles

Background of study: Experimental research supports the hypothesis that fetal exposure to androgen excess may programme in utero the development of PCOS in adult life. Potential mechanisms for prenatal androgenization could be a reduced binding capacity of androgens by SHBG or reduced aromatization of androgens by aromatase. The aim of this study was to examine whether the SHBG(TAAAA)n polymorphism, known to be associated with SHBG levels and the CYP19(TTTA)n<...

ea0014oc6.6 | Cardiovascular endocrinology | ECE2007

The importance of the TAAAA(n) alleles at the SHBG gene promoter for the severity of cardiovascular disease in women

Saltiki Katerina , Xita Nectaria , Cimponeriu Adriana , Kanakakis Ioannis , Mantzou Emily , Doukas Charalambos , Georgiou Ioannis , Alevizaki Maria

Objective: Androgen may be detrimental in the development of coronary artery disease (CAD) in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and the severity of CAD in women.Methods: One hundred and twenty women (37–82 yrs), undergoing coronary angiography. CAD severity, history of angina, myocardial infa...