Endocrine Abstracts

We present a case of a 44-year-old female with fluctuating thyroid function over 12-14 years. The patient originally presented with a high TSH, normal free T3/T4 and a negative anti-TPO antibody. She was initially monitored, then went onto Levothyroxine replacement in an antenatal setting. Subsequently, 12-18 months later, she presented with hyperthyroid symptoms and vastly elevated TSH-receptor-antibody (TSHR-ab) titre of >10 IU/L, the upper limit of normal being 2.9 IU/L...

A recent case series commented on adverse COVID-19 outcomes among patients with Cushing’s syndrome, despite minimal symptoms and low inflammatory markers. Excessive glucocorticoids can impede adaptive immune response to viruses, leading to increased infection risks (1). Sarker et al discussed glucocorticoids binding to viral spike-proteins, inhibiting receptor interactions and contributing to prolonged positive swabs, in the absence of symptoms (2). We report the c...

A 70-year old gentleman was referred to the endocrine clinic by the Cardiology team following an admission with blackouts- three in three years, two causing road traffic accidents. During one of the accidents, his capillary blood glucose reading dropped below 3 mmol/l. The patient reported dizzy spells, accompanied by hot flushes, sweats, tremor, change in colour- “looking grey”, feeling hungry and nausea, alleviated by sugary snacks. These episodes were linked to mi...

A 61-year old woman, referred to the endocrine clinic, post Roux-en-Y gastric bypass, exhibited symptoms of dizziness, weakness, light-headedness and sweating. These symptoms were associated with light meal following prolonged fast. A clinical diagnosis of reactive hypoglycaemia was made. She was advised to make lifestyle modification and adopted a low glycaemic index diet. Baseline bloods including cortisol, IGF-1 and urinary metanephrine were within reference range. Mixed me...

Objectives: We present findings from the UK arm of the THESIS collaboration, a pan-European survey of endocrinologists’ opinions and current practice in the management of hypothyroid and euthyroid disorders.Methods: UK clinical members of the Society of Endocrinology and the British Thyroid Association were invited to participate in an online survey.Results: 272 of 1295 (21%) eligible members completed the survey. More than 50...

Background: Reactive hypoglycaemia following Roux-en-Y gastric bypass (RYGB) surgery poses unique challenges in diagnosis and management. This abstract explores the utility of Metformin and GLP-1 analogues in two distinct cases.Case 1- LH: LH, a post-RYGB patient, presented with recurrent hypoglycaemic episodes, intriguingly manifesting primarily at night; after a long day at work in a fasted state followed by a carbohydrate heavy meal. LH experienced hy...