Endocrine Abstracts

Background: Work-up of thyroid nodules remains challenging. Fine needle aspiration (FNA) has been shown to be the most cost–effective way to select patients for surgery with sensitivities of 54–69% and specificities of 60–96% for the detection of malignant lesions. Ultrasound-based Realtime Elastography (RTE) enables the determination of tissue elasticity and has shown promising results for the differentiation of thyroid nodules. A meta-analysis was performed to...

Background: Osteolytic metastases of the bone occur in several malignant tumors. Beside osseous metastases, endocrine diseases like primary hyperparathyroidism can mimic osteolytic metastases.Case report: A 53-year-old woman was sent to the hospital by an oral surgeon with a worsening of her general condition, fatigue, a painful tumor of the mandible, diffuse bone pain and the diagnosis of a suspected metastasized malignancy. Laboratory testing showed a ...

Background: Adrenal masses can be detected by ultrasound with high sensitivity and specificity. However, a differentiation between benign and malignant adrenal masses is presently not possible. Contrast-enhanced ultrasound has been studied intensively with excellent results for the characterization of liver lesions.The aim of the present study was to evaluate the value of contrast-enhanced ultrasound for the characterization of adrenal mass in a proof of...

Background: Adrenal masses can be detected by ultrasound with high sensitivity and specificity. However, a differentiation between benign and malignant adrenal masses is not possible with conventional ultrasound. Contrast-enhanced ultrasound (CEUS) is a established method for the characterization of focal liver lesions. A first pilot study (n=35) analyzing the dynamics of contrast-enhancement during CEUS reported a high sensitivity for differentiation of benign and mali...

Background and aims: The aim of the present study was to evaluate real-time elastography (RTE) and contrast-enhanced ultrasound with Sonovue (CEUS) for the differentiation of benign and malignant thyroid nodules using cytologic/histologic analysis as reference method. While first studies have reported excellent results of RTE for the differentiation of thyroid nodules, data on CEUS of the thyroid are rare.Methods: RTE was classified as: score 1=soft, 2=p...

Introduction: Work-up of thyroid nodules remains challenging. Thyroid imaging reporting and data system (TIRADS) has been developed to improve patient management and cost-effectiveness by avoiding unnecessary fine needle aspiration biopsy (FNAB) in patients with thyroid nodules. However, since its publication in JCEM (2009) its clinical use is still very limited and its practicability in clinical practice is questioned. Realtime-elastography (RTE) enables the determination of ...

Background: Previously, we reported an association of vitamin D receptor (VDR) polymorphisms and differentiated thyroid cancer (DTC) risk. The aim of the present study was to investigate other vitamin D pathway genes such as CYP27B1, CYP2R1 and CYP24A1 which code for enzymes that, respectively, synthesize and degrade 1,25(OH)2D3 in patients with DTC and healthy controls (HC). Also its influence on 25(OH)D3 and 1,25(OH)2D3 ...