Searchable abstracts of presentations at key conferences in endocrinology

ea0063p155 | Diabetes, Obesity and Metabolism 1 | ECE2019

Improvement of human pancreatic islet quality after co-culture with human adipose-derived stem cells

de Souza Bianca , Rodrigues Michelle , de Oliveira Fernanda , da Silva Liana , Boucas Ana Paula , Portinho Ciro , dos Santos Bruno , Camassola Melissa , Martini Juliano , Leitao Cristiane , Nardi Nance , Bauer Andrea Carla , Crispim Daisy

Introduction: Pancreatic islet transplantation is an effective treatment for patients with type 1 diabetes mellitus (T1DM) with unstable metabolic control. However, the quality of islets isolated from a donor is negatively affected by the inflammatory environment related to the donor’s brain death and by the stress related to islet isolation and culture. To overcome islet quality loss, some studies have co-cultured islets with mesenchymal stromal cells (MSCs). Considering...

ea0032p746 | Obesity | ECE2013

Green tea catechins attenuate high-fat diet effects related to obesity and diabetes without effect hypothalamic expression of TLR4 pathway or serotoninergic 1B and 2C receptors

Okuda Marcos Hiromu , Alves de Santana Aline , Moreno Mayara Franzoi , Hachul Ana Claudia , Neto Nelson Inacio , dos Santos Bruno , Oller do Nascimento Claudia Maria , Zemdegs Juliane , Ribeiro Eliane Beraldi , Oyama Lila Missae

Many mechanisms are proposed for green tea’s role as anti-obesity and anti-diabetic natural product. Two of them involve the hypothalamic control of energy balance: i) high-fat diets (HFD) rich in saturated fats induce low-grade inflammation, leading to leptin and insulin resistance; ii) serotonin receptors (SR) 1B and 2C activation have anorexigenic effects, SR2C activation improves insulin sensitivity, and HFD can also impair this system. We investigated the effects of ...