Endocrine Abstracts

Background: Diabetes mellitus, hypovitaminosis D, and non-alcoholic fatty liver disease (NAFLD) are common medical conditions that share some risk factors, one of which is obesity. Both NAFLD and vitamin D deficiency have been linked to the development of metabolic syndrome and type 2 diabetes. The aim of this study is to evaluate the level of serum 25-hydroxy vitamin D [25(OH)D] in type 2 obese diabetic Egyptian patients with variable degrees of hepatic steatosis.<p class...

Background: Chronic kidney disease secondary to type 2 diabetes is associated with multifactorial energy dysmetabolism. Irisin has been identified recently as an exercise induced hormone secreted by skeletal muscles. It is hypothesised that patients with CKD may have altered irisin levels.Aim of the work: We aimed to study irisin hormone in type 2 diabetic patient and to assess its relation with diabetic nephropathy (DN).Subjects a...

Introduction: Guidelines have, for some time, suggested a lower threshold for surgical intervention in primary hyperparathyroidism based on serum calcium alone. Furthermore, PHPT is a common metabolic bone disorder which is associated with further complications. In order to assess the impact of the lower threshold on surgical services and management implications for associated complications, we report baseline characteristics in a cohort of patients with confirmed PHPT.<p ...

Introduction: Eighty percent of patients with PHPT have co-existing vitamin D deficiency. Few large studies have assessed the impact/safety of different vitamin D preparations on calcium, PTH and vitamin D in such patients. We report the use of three different preparations.Methods: In a retrospective study of 125 patients with confirmed PHPT, 77% were vitamin D deficient (<30 nmol/l)/insufficient (30–50 nmol/l). We assessed the impact and safety...

Background: BCAAs up regulate glucose transporters and activate insulin secretion has been widely demonstrated. However, several researchers have suggested that excessive intake of amino acids could lead to inhibition ofinsulin signalling. BCAAs may induce insulin resistance throughm TOR activation insulin resistance may be linked with high intake of BCAAs, Controversiesremain on whether an increase in plasma BCAA levels is a cause or consequence of insulin resistance.<p c...

Objective: To study the growth response to GH treatment in GH deficient patients. Also to report the possible side effects emerging during treatment with GH.Patients and methods: 477 GH deficient (GHD) children were included in the study. All patients received biosynthetic GH therapy at a dose of 20 IU/m2 per week. Patients were followed up for a minimum of 1 year and up to 6 years as anthropometric assessment was performed every 3 months, whi...

Background: Toll-like receptors (TLRS) are a class of proteins that play a key role in the innate immune system. They are single, membrane, non catalytic receptors which are expressed in multiple tissues predominantely cells of the innate immune system especially monocytes. So, they play a critical role in the regulation of immune function and inflammation.Aim of our work: To study the expression of toll-like receptor 2 and 4 on monocytes in T1DM patient...

Background: Anorexia is a problem of paramount importance in patients with advanced liver cirrhosis contributing to malnutrition. In turn, malnutrition is a risk factor for the development of life-threatening complications and increased mortality. Ghrelin hormone; an important orexigenic agent has been postulated to integrate anabolic changes in the body.Aim: To assess ghrelin level in Egyptian patients with liver cirrhosis and hepatocellular carcinoma.<...

Content: Type 2 diabetes mellitus (T2DM) may be associated with disorders in innate immune system. Toll-like receptor 2 (TLR2) is an important mediator of the innate immunity with subsequent proinflammatory reactions that thought to be involved in the cardiovascular complications in T2DM.Objective: We evaluate the role of TLR2 in T2DM patients with cardiovascular complications.Patients and methods: The study was conducted on 60 pat...

Background: Body Mass Index (BMI) and waist circumference (WC) are currently used to assess obesity. BMI and WC do not take into account fat/muscle distribution or allow for distinctions between gender, age or ethnicity. WC reflects abdominal fat distribution more accurately, but is operator-dependant and variable in terms of reproducibility. BVI is a totally new, reproducible and novel concept using a 3D body scanner and appropriate software, to measure total body and 8 body ...