Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep999 | Thyroid | ECE2022

Serum selenium status in UK Graves’ disease patients with and without orbitopathy

Maden Carla , Eng Pei Chia , Choa Dri , Agha-Jaffar Rochan , Cox Jeremy , Yee Michael , Robinson Stephen , Fayers Tessa

Introduction: Selenium supplementation is recommended for all patients with mild Graves’ orbitopathy (GO). The thyroid gland contains high levels of selenium, which has an anti-oxidant effect and a role in the metabolism of thyroid hormones. The study on which this recommendation is based was conducted in countries of a selenium-deficient region and did not measure subjects’ selenium concentrations. There is therefore no consensus on optimum dose, duration, or safety...

ea0081ep1099 | Thyroid | ECE2022

COVID-19 vaccine-associated subacute thyroiditis

Chia Eng Pei , Davidson Lien , Agha-Jaffar Rochan , Cox Jeremy , Yee Michael , Moriarty Maura , Robinson Stephen , Vakilgilani Tannaz , Bravis Vassiliki

Introduction: Subactue thyroiditis (SAT) is a self-limiting inflammatory condition caused by follicular destruction of the thyroid gland, commonly precipitated by viral upper respiratory tract infection 2 weeks preceding the onset of thyroid symptoms. However, SAT following COVID-19 vaccination is rare. Herein, we report two cases of subacute thyroiditis which presented after administration of COVID-19 vaccine. Case series: The first patient was a 42 yea...

ea0086p167 | Adrenal and Cardiovascular | SFEBES2022

The Value of Baseline Cortisol in Predicting a Preserved Cortisol Response to Synacthen

Suh Sarah , Agha-Jaffar Rochan , Choa Dri , Bravis Vassiliki , Vakilgilani Tannaz , Yee Michael , N Comninos Alexander , Cox Jeremy , Robinson Stephen

Background: Adrenal Insufficiency (AI) presents a diagnostic and clinical challenge. While short Synacthen Tests (SSTs) are most commonly utilised to diagnose AI, the value of a baseline cortisol is being explored. We aimed to review indications for performing an SST and to determine the baseline cortisol that predicted a preserved cortisol response to Synacthen.Methods: Eight hundred and sixty SSTs performed in 621 individuals at a tertiary endocrinolog...

ea0086p37 | Bone and Calcium | SFEBES2022

The management of autosomal dominant hypoparathyroidism with CaSR mutation in pregnancy and breastfeeding

Halim Sandra , Rahim Haaris , Avari Parizad , Mulla Kaenat , Freudenthal Bernard , N Comninos Alexander , Agha-Jaffar Rochan , Robinson Stephen , Cox Jeremy

Autosomal dominant hypoparathyroidism (ADH) is caused by gain-of-function mutations in the calcium-sensing receptor (CaSR), increasing its sensitivity to extracellular calcium, suppressing PTH and resulting in hypocalcaemia. In contrast to idiopathic hypoparathyroidism, treatment to correct serum calcium results in high urine calcium excretion, causing nephrocalcinosis, stones and renal impairment. Unlike surgical hypoparathyroidism where calcium should be maintained, patients...

ea0090ep329 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

A case series of monogenic diabetes in pregnancy

Nyunt Sandhi , Agha-Jaffar Rochan , Hardy Maud , Racaru Simona , Cunsolo Roberto , Yu Christina , Terry Jayne , Misra Shivani , Robinson Stephen

Monogenic diabetes is estimated to account for 1-2% of all diabetes cases diagnosed before the age of 45. It is caused by mutations in genes encoding for beta cell development, function and regulation. We present three cases of monogenic diabetes in pregnancy.Case 1: Age 30, Para 3, White ethnicity. This individual was screened for a GCK mutation at 18 weeks gestation (third pregnancy) on the basis of family history. She required metformin and insulin to...

ea0091wd4 | Workshop D: Disorders of the adrenal gland | SFEEU2023

Cushing’s syndrome: keep searching, and then search for more!

Kapoor Ashutosh , Singh Ainesh , Vaineri Erika , Agha-Jaffar Rochan , Jones Ben , Cox Jeremy , Wernig Florian , Robinson Stephen , Al-Sahaf May

We present the case of a 53-year-old lady who was recently diagnosed with Type 2 Diabetes, Hypertension and Dyslipidaemia. She was referred by the lipid clinic with a 3-month history of progressive facial swelling, hyperpigmentation and proximal myopathy. Clinical history and examination were highly suspicious of endogenous hypercortisolaemia. An initial overnight dexamethasone suppression test yielded an elevated morning cortisol (752 nmol/l, normal <50nmol/l). Two 24-hou...

ea0037oc12.1 | Pituitary – Clinical | ECE2015

The Irish TSHoma study: a multicentre retrospective study

Pazderska Agnieszka , Cuesta Martin , Wallace Helen , Melvin Audrey , Gibney James , Agha Amar , O'Halloran Donal , Hunter Steven , Thompson Chris , Sherlock Mark

TSH-secreting pituitary adenomas (TSHomas) are rare. Previously, the reported prevalence was one case per million populations although this is probably an underestimate. A recently published study reported a prevalence of TSHomas in Sweden of 2.8/million inhabitants.Methods/design: Observational study conducted in four tertiary referral centres in Ireland. We retrospectively collected data on the prevalence, demographics, hormonal profile, tumour charact...

ea0037gp.04.07 | Steroids | ECE2015

Differential regulation of 11β-hydroxysteroid dehydrogenase type 1 activity in patients with differing aetiologies of hypopituitarism

Behan Lucy Ann , Rogers Bairbre , Maher K , Taylor Norman F , Smith Diarmuid , Thompson Chris J , Monson John P , Agha Amar

Pituitary patients with different aetiologies of hypopituitarism exhibit differing phenotypes despite optimal replacement therapy. We hypothesised that differential regulation of the isoenzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which mediates the autocrine conversion of cortisone to cortisol in adipose tissues and liver may play a role.We prospectively studied 11β-HSD1 activity through analysis of 24 h urine cortisol/cortisone ...

ea0037ep1035 | Thyroid (non-cancer) | ECE2015

Hypothyroidism related to blocking TSH receptor antibodies after allogenic haematopoietic stem cell transplantation

Benomar Kanza , Massart Catherine , Magro Leonardo , Parent Anne Sophie , D'Herbomez Michele , Yacoub-Agha Ibrahim , Wemeau Jean Louis , Vantyghem Marie Christine

Besides total body irradiation and immunosuppressive drugs, massive iodine supply and stress might participate in thyroid dysfunction, described in 50% of allo-HSCT. We report on a rare case of hypothyroidism related to blocking TRAb. A 55-year-old man was admitted for asthenia, dyspnea, myalgia, 8 kg-weight gain, constipation, dry skin, hoarse voice, recent deafness. He had moon face without any goiter. He had received, 1 year before, an unrelated 9/10 human leukocyte antigen...

ea0037ep1226 | Clinical Cases–Pituitary/Adrenal | ECE2015

A case of IgG4 related hypophysitis in a Caucasian female

Hannon Anne Marie , Gupta Saket , Slattery Dave , McGurran Karen , Kinsley Brendan , Javadpour Moshen , Brett Francesca , Agha Amar

IgG4 related hypophysitis is a recently described entity belonging to the IgG4 related diseases. It is characterised by markedly elevated serum IGG4 levels and tissue infiltration by IgG4 positive plasma cells. To date, 34 cases of IgG4 related hypophysitis have been described but only a handful were in women or biopsy proven. We describe a case of a 58 year old woman who presented with transient headache. She also complained of polyuria and nocturia. She had a thyroidectomy f...