Endocrine Abstracts

This study aims to explore the baseline adipocytokine profiles of adult Saudis and evaluate their relationship in the development of insulin resistance. Three hundred adult Saudis with varying glucose tolerance were recruited. They were grouped into NGT, IGT and DM. Anthropometrics, glucose and lipid profiles were analyzed by routine methods; leptin, adiponectin, resistin and CRP were measured by ELISA. Insulin resistance was significantly correlated with levels of CRP (R</...

The aim of this study was to evaluate the effect of testosterone treatment on the pattern of prostate cells proliferation and differentiation and their correlation with transforming growth factor-beta expression. Prostate gland development was compared in intact immature dogs with testosterone treated immature dogs for one month. Proliferation and differentiation pattern of prostatic cells were assessed by histological and immunohistological localization of proliferating cell ...

Background: The diabetes management clinics in primary health care centres in Oman aim to provide interdisciplinary diabetes management for their patients. The interdisciplinary management is proved in the literature to have successful outcomes and help the patients to reach their glycemic control fast and safe. Therefore the diabetes management in Oman follows national guidelines, which are based on IDF and AACE guidelines and support the interdisciplinary approach. Despite t...

Background: The worldwide type 2 diabetes mellitus (T2DM) prevalence is increasing dramatically. Inflammation is involved in the pathogenesis of T2DM and development of insulin resistance. Lack of diabetic control is associated with alteration in the endocrine milieu and various health sequalae’s. The aim of this research was to assess if uncontrolled T2DM is associated with increased serum levels of inflammatory cytokines and growth factors when compared with controlled ...

Gonadotropin-releasing hormone (GnRH) is the master hormone regulating the reproductive axis and its pulsatile secretion is crucial for puberty onset and fertility. Disruption in GnRH neuron development or hypothalamic function can lead to absent or delayed puberty (DP) due to GnRH deficiency, with a phenotypic spectrum from severe delayed puberty to partial or complete Hypogonadotropic Hypogonadism (HH). HH can also be present as a shared trait with other neurodevelopmental d...

Introduction: Sarcoidosis is a multisystem inflammatory disorder that affects the lungs and the lymph nodes commonly. The involvement of the nervous system in this disease is infrequent with prevalence lower than 10%. The diagnosis could be challenging when the neurologic disease presents in a patient without previously known sarcoidosis.Case Report: A 39-year-old Caucasian gentleman was brought to the Emergency department with a one week’s history ...

Introduction: Anti-thyroid drugs like Carbimazole and Propylthiouracil are widely used in the management of hyperthyroidism. These medications are associated with a spectrum of cutaneous, hematologic, teratogenic and hepatobiliary adverse effects.Case Report: A 65-year-old lady, known to have asthma on inhalers as needed and no history of allergies. She was diagnosed with Graves’ thyrotoxicosis after she presented to her General Practitioner with mo...

The association between hypomagnesaemia and proton pump inhibitors (PPIs) has been well-established in recent years, with a median onset of electrolyte disturbance around 5.5 years after PPI initiation. The mechanisms and aetiology of this potentially life-threatening side-effect remain unclear. We assessed the prevalence of PPI usage in all cases of severe hypomagnesaemia (defined for the purposes of the study as a magnesium level <0.4 mmol/l) in our hospital over the cou...

Background: Pancreatic Neuroendocrine Tumours (pNETs) can be associated with cancer susceptibility syndromes such as Multiple Endocrine Neoplasia type 1 (MEN1). MEN1 increases a person’s chance of developing pNETs, which are the main cause of mortality in this cohort. A diagnosis of pNETs, therefore, provides the opportunity for detection of associated MEN1 and subsequent identification of asymptomatic relatives who would then undergo relevant clinical, biochemical and ra...

Vitamin D deficiency is highly prevalent among Saudi women. The aim of this study was to determine the prevalence of cardiometabolic risk factors in apparently healthy Saudi women with vitamin D deficiency. A Retrospective chart review was conducted in the “Center of Excellence for Osteoporosis Research” (CEOR), King Abdulaziz University, Jeddah, Saudi Arabia. Only healthy women 20–40 years old, with no history of previous illnesses and not on any medications we...