Endocrine Abstracts

2-Methoxyoestrogens are emerging as a new class of anti-neoplastic agents. 2-Methoxyoestradiol (2-MeOE2), an endogenous oestrogen metabolite, has shown anti-proliferative effects in ER+ve and ER-ve breast cancer cell lines. In this study we have investigated the effects of sulphamoylated derivatives of 2-MeOE2, 2-methoxyoestradiol-3-O-monosulphamate (2-MeOE2MATE) and 2-methoxyoestradiol 3,17 bis sulphamate (2-MeOE2bisMATE) in ER-ve MDA-MB-231 cells. Both 2-MeOE2MATE and 2-MeOE...

The factors affecting counterregulatory (CR) responses to hypoglycaemia in T2DM remain uncertain. Previous studies have suggested an effect of glycaemic control on CR responses in T2DM. Little data exists on the effect of treatment with metformin (MET) vs. Sulphonylurea (SUL) on the CR responses to hypoglycaemia in T2DM.To date, we have performed stepped hypoglycaemic hyperinsulinaemic clamp studies (2-4 mU/kg/min) on 5 subjects treated with MET (Age 50....

Background: Dyshormonogenetic goiter and Hashimoto’s thyroiditis are amongst the commonest causes of hypothyroidism in children and adolescents Worldwide. But, the genetic basis and their hypothyroid phenotypes are under-reported, especially from developing countries. In this context, we screened for dyshormonogenetic mutations in hypothyroid children with dyshormogenetic goiter (DH) and Hashimoto’s thyroiditis (HT).Material and methods: In thi...

Introduction: Placenta has many essential roles to maintain pregnancy and homeostasis. Calcium transport and its regulation are also important for vital roles of placenta. In general, calcium transport is regulated by active transcellular and passive paracellular pathways. Transient receptor potential cation channel subfamily V member 5/6 (TRPV5/6), calbindin-D9k (CaBP-9k), calbindin-D28k (CaBP-28k), and Na+/Ca2+ exchanger (NCX1) are involved in the transcellular pathway. Para...

Even though it is unusual, many cases presenting with combinations of thyroid carcinomas have been reported. Concurrent occurances of medullary – papllary carcinoma, follicular – papillary – medullary carcinoma, follicular – anaplastik – papillary carcinoma, papillary – follicular carcinoma have been presented. The cases reported up to now had no thyroid autoimmunity. We present a case with known Hashimoto’s thyroiditis having a combination o...

Introduction: Hyponatraemia is common biochemical abnormality in hospitalised patients and is difficult to manage in some cases. Tolvaptan is presently licensed in the UK for the treatment of hyponatraemia secondary to SIADH. We present our experience of using Tolvaptan.Cases: Patient 1 was admitted with sagittal sinus thrombosis. Over 9 days serum sodium dropped from normal to 121 mmol/l with biochemical evidence of SIADH. The patient was treated with T...

A 66 years old woman on orthopedic clinic, was resection of tibias tumor in both legs because was suspicion of primary bone neoplasm or metastases (X-ray showed osteolytic lesion). Histology was: osteitis fibrosa cystica - Brown tumor. After resection the patient was referred to the endocrinologist because of persistently high calcemia (3.3 mmol/l). Blood tests showed normal CRP but elevated alkaline phosphatase of 173 U/l. Phosphate was low at 0.75 mmol/l (0.81–1.58). Pa...

Children with androgen insensibility and female sexual external organs usually are classified as girls. In the puberty observed is the development of female secondary sexual features without menstruation. The treatment of patients with androgen insensibility, because of the risk of neoplastic transfomation must be preceded by castration. Case report: a 14 year old girl was admitted in 2003 to the Clinic with the following anamnesis: birth from the secondary gravidity, normal d...

We examined the effects of L-thyroxin on level of prolactin (PRL), CRP (C-reactive protein) and insulin in premenopausal women with subclinical hypothyreoidism (SH).The study included 21 women ages 41.3±3.5 years with SH (TSH>mIU/ml with normal level of T3 and T4).Laboratory evaluation included basal hormone (serum free T3, free T4, TSH, PRL, insulin, cortisol, ACTH, GH, FSH, LH, E2, thyroid antibodies and TGL), level of C...

Alterations in the rate of glucocorticoid(GC) metabolism induce compensatory changes in GC secretion under the control of the hypothalamic-pituitary-adrenal (HPA) axis. The principal routes of metabolic clearance of GCs are by hepatic A-ring reduction however the regulation of these enzymes is poorly understood. Recently we and others have demonstrated that bile acids act as potent inhibitors of GC metabolism by 5beta-reductase and 11beta-hydroxysteroid dehydrogenases in vi...