Searchable abstracts of presentations at key conferences in endocrinology

ea0031p265 | Pituitary | SFEBES2013

Examining the distribution of abdominal fat in GH deficiency using magnetic resonance imaging

Sinha Akash , Hollingsworth Kieren , Ball Steve , Cheetham Tim

Background: Adults with GH deficiency (GHD) have altered body composition with an increase in abdominal fat when compared with healthy matched controls. However, most studies have not compared GHD adults with GHD adults on GH replacement.Abdominal fat is composed of subcutaneous abdominal tissue (SAT) and visceral abdominal tissue (VAT). Increased VAT is associated with poor metabolic outcomes. Magnetic Resonance Imaging (MRI) is a reliable and reproduci...

ea0030oc2.3 | Oral Communications 2 | BSPED2012

Does vitamin D modulate mitochondrial oxidative phosphorylation?

Sinha Akash , Ball Steve , Hollingsworth Kieren , Cheetham Tim

Introduction: Mitochondria are critical organelles which generate most of the energy (ATP) in the eukaryotic cell by oxidative phosphorylation. Impaired mitochondrial function will, therefore, restrict myocellular function. Vitamin D deficiency is widely prevalent with fatigue amongst its commonest manifestation. 31P-MRS is a non-invasive technique used to measure skeletal muscle bioenergetics in vivo. We have examined the relationship between vitamin D and mitochon...

ea0030p49 | (1) | BSPED2012

Mind over muscle: investigating the biology of fatigue in GH deficiency using 31P-MRS

Sinha Akash , Hollingsworth Kieren , Ball Steve , Cheetham Tim

Introduction: Even though fatigue is a common complaint in GH deficiency (GHD), its pathophysiology remains poorly understood. Fatigue can reflect central or peripheral disease processes. 31-Phosphorus magnetic resonance spectroscopy (31P-MRS) is a non-invasive technique used to measure skeletal muscle bioenergetics in vivo. Specifically, mitochondrial oxidative phosphorylation and proton efflux can be measured dynamically and in ‘real time’. The ai...

ea0028p120 | Clinical practice/governance and case reports | SFEBES2012

Bacterial meningitis as first presentation of pituitary macroprolactinoma

Aggarwal Naveen , Khan Hamza , Mitra Dipayan , Ball Steve

A 37 year old gentleman with no significant past medical history presented with 2 day history of acute onset headache, nausea, vomiting, photophobia and fever. He was pyrexial. He had no focal neurological deficit but marked neck stiffness. His inflammatory markers were raised. CT head showed large pituitary tumour. He was started on Dexamethasone and IV Ceftriaxone and transferred to tertiary centre. MRI brain showed large pituitary macroadenoma projecting into right cavernou...

ea0005p97 | Diabetes, Metabolism and Cardiovascular | BES2003

Altered insulin sensitivity and secretion in sotos syndrome

Nag S , Bennett S , Gerrard J , Walker M , Ball S

Background: Sotos syndrome is an uncommon condition characterised by rapid growth, large body size and acromegaloid facies.There is limited data on metabolic abnormalities in Sotos syndrome.Aims: We investigated insulin sensitivity and secretion rates in a 22 year old girl with Sotos syndrome, prompted by the observation of a flat glucose response after an oral glucose challenge.Methods: Glucose tolerance was assessed with a 75g 2-h oral glucose tolerance test (OGTT), ...

ea0002p12 | Clinical case reports | SFE2001

Severe hyperandrogenism with polycythaemia: use of metformin as a therapeutic and diagnostic tool

Senior P , Ball S , Baylis P , Quinton R

Polycystic ovarian syndrome (PCOS) is the commonest cause of hyperandrogenism in women. Severe hyperandrogenism or virilisation, however, suggest the need to consider rarer causes e.g. Cushing's, congenital adrenal hyperplasia and androgen-secreting tumours. Here we present a case of PCOS where the remarkable response of severe hyperandrogenism with polycythaemia to metformin excluded these rarer causes without the need for complex or invasive investigation.<p class="abste...

ea0051p092 | Diabetes | BSPED2017

Description of the prevalence, demographics and service provision for children with autism or epilepsy in our type 1 diabetes clinic

Smith Chloe , Moran Maria , Ball Amy , Drew Josephine , Denvir Louise , Randell Tabitha , Sachdev Pooja

Background: Previous reports suggest that epilepsy and autism are more common in children with autoimmune diseases such as type 1 diabetes (T1D). While each condition is common in the general population, only small numbers of children have the two conditions together, so there is currently little coordinated support. We sought to describe the incidence in our own population.Methods: Retrospective review of the Diamond database and clinical notes for chil...

ea0086p93 | Neuroendocrinology and Pituitary | SFEBES2022

Circadian/diurnal rhythm profiles of serum and salivary melatonin, cortisol and cortisone, determined by liquid chromatography tandem mass spectrometry (LC-MS/MS)

Webb Bethany , Dunn Rachel , Ball Nicole , Fraser William , Lazar Alpar , Michalak Adriana , Voysey Zanna , Tang Jonathan

Background: Melatonin and cortisol production demonstrate circadian rhythms; disruption of these rhythms feature in endocrine and neurodegenerative disorders, such as Addison’s disease, Huntington’s disease (HD) and Alzheimer’s disease (AD). Measuring serum and saliva concentrations at nadir is challenging using immunoassays. We have developed LC-MSMS methods for measuring serum and saliva melatonin, cortisol and cortisone to analyse 24hr profile samples obtained from sleep st...

ea0044p210 | Reproduction | SFEBES2016

Safety and tolerability of inducing completion of puberty with IM testosterone over 1 year in older men with congenital hypogonadism and absent puberty

Pazderska Agniezska , Artham Satish , Miller Margaret , Morris Margaret , Ball Steve , Quinton Richard

Background: Guidance on pubertal-induction in hypogonadal adult men is sparse. For adolescent boys, in whom delay is usually constitutional, treatment is typically initiated with pulsed low-dose IM testosterone (T); the dose being progressively increased if/when it becomes clear that endogenous gonadotrophin secretion is not being initiated. In teenagers with organic hypogonadism, the aims are to recapitulate the normal tempo of puberty over 2–3 years and optimise linear ...

ea0032oc1.6 | Pituitary &amp; Molecular Endocrinology | ECE2013

Management of euvolemic hyponatremia attributed to SIADH in the hospital: interim results from a prospective, observational, multi-center, global registry

Peri Alessandro , Verbalis Joseph , Greenberg Arthur , Johannsson Gudmundur , Ball Steven , Jorgensen Jens Otto , Chiodo Joseph

Introduction: Hyponatremia (HN) is the most common electrolyte disorder of hospitalized patients (pts). It occurs in up to 28% of in-pts, increases the in hospital risk of death by 1.47 fold, and is associated with significantly higher mortality risk following discharge. The HN Registry is the first large scale, international effort to document the clinical characteristics, treatments used, and impact of HN in hospital settings.Methods: After informed co...