Endocrine Abstracts

Introduction: Surgical treatment is indicated in patients with dopamine agonist-resistant macroprolactinoma. However, the resection of the tumor is usually partial because of fibrotic changes under long-term dopamine agonist therapy. Thus, early identification and management of patients at high risk of dopamine agonist resistance is crucial to a complete resection outcome and a better remission. The aim of this study was to develop a score predicting dopamine agonist resistanc...

Introduction: Hodgkin lymphoma is a cancer that affects the lymphatic system. Treatment includes chemotherapy and radiation therapy, which can increase the risk of secondary cancers such as thyroid and ovarian carcinomas. We report a case of a patient who developed secondary thyroid and ovarian cancers after being treated for Hodgkin’s disease.Observation: Mrs LS was diagnosed with Hodgkin disease at the age of 34 and was treated with chemotherapy a...

Introduction: Papillary Thyroid Carcinoma (PTC) is the most frequent cancer of the thyroid. PTC may rarely coexist with Primary hyperparathyroidism (PHPT). Furthermore, the association of PTC and graves’ disease (GD) has been described and the existence of a link between these entities has long been investigated, but no clear correlation has been established. We report the case of a female patient who suffered from GD, PTC and PHPT.Observation: A 34...

Introduction: Papillary thyroid carcinoma is one of the most prevalent endocrine tumors. Adrenocorticotropic hormone (ACTH) dependent Cushing’s syndrome is a rare disease. We report a rare case of coexistence of papillary thyroid carcinoma and ACTH-dependent Cushing’s syndrome.Observation: A 59-year-old man, was admitted to our endocrinology department for exploration of bilateral adrenal incidentalomas discovered in an abdominal CT scan done i...

Introduction: Gilbert syndrome is a common autosomal dominant hereditary condition characterized by intermittent unconjugated hyperbilirubinemia in the absence of hepatocellular disease or hemolysis. Multiple endocrine neoplasia (MEN) is defined by the association of a neoplasia or hyperplasia of at least two endocrine glands and caused by multiple mutations. Rare cases of atypical MEN were reported in the literature. We report the case of a patient with a history of gilbert&#...

Introduction: Liraglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA), approved for management of type 2 diabetes (T2D).Aim: The aim of our study is to evaluate the effectiveness of Liraglutide in controlling blood glucose levels over a period of 6 to 12 months in Tunisian type 2 diabetic patients.Methods: We conducted a prospective descriptive study at the endocrinology-nutrition department of the military hospital of...

Introduction: Liraglutide has been shown to have a positive effect on the glycemic and lipidic profile of diabetic patients. We aimed to assess the metabolic profile in type 2 diabetic patients after 12 weeks of treatment by LiraglutideMethods: This is a prospective study performed at the endocrinology department of the Military Hospital of Tunis. We recruited 22 patients with type 2 diabetes (T2D) treated with insulin and/or oral antidiabetics. Liraglut...

Introduction: Glycemic control and weight management are crucial considerations in the treatment of type 2 diabetes (T2D). Liraglutide, an incretin-based therapy, has been demonstrated to not only effectively maintain glycemic control but also promote weight loss in type 2 diabetic patients. Our study aims to evaluate the impact of Liraglutide on body weight and body composition parameters in patients with T2D.Methods: This is a prospective study, carrie...

Introduction: Liraglutide is an anti-diabetic drug that has been shown to be effective for glycemic control and weight loss. However, factors such as unavailability, high cost, and side effects may make it challenging for patients to continue treatment. Our study aims to identify these barriers to treatment adherence and to understand the factors contributing to the discontinuation of Liraglutide therapy in Tunisian patients with type 2 diabetes (T2D).Me...

Introduction: Giant pituitary adenomas are defined as tumors with largest diameter ≥40 mm. They are characterized by high invasiveness causing compression of adjacent structures and hormonal dysfunction. The aim of this study was to determine the clinical and paraclinical features, management, and outcome of giant pituitary adenomas.Methods: This was a single-center retrospective study including patients with giant pituitary adenoma. Clinical and p...