Endocrine Abstracts

Background: Clinical and molecular findings have shown that parathyroid hormone (PTH) affects the heart and vasculature through downstream actions of G protein-coupled receptors in the myocardium and endothelial cells. Furthermore, the endothelium is a recognised target tissue of PTH and there is an increasing body of evidence that PTH affects functional and structural properties of arteries. Patients with chronic post-surgical hypoparathyroidism (hypoPT) have higher incidence...

Medullary thyroid cancer (MTC) is a rare malignancy of the thyroid gland. MTCs originate from thyroid-C cells and account for 2-4% of all thyroid neoplasms. Originating from thyroid-C cells, the main secretory product of MTCs is calcitonin, used as sensitive and specific MTC-biomarker. Calcitonin is a hormone known to participate in calcium-bone metabolism suppressing bone-resorption by inhibiting the activity of osteoclasts, and inhibiting the kidney reabsorption of calcium a...

Background: Altered sleep quality and duration have been reported in 26-67% of patients with type 1 diabetes (T1D). However, differences in study designs, populations, and methods of sleep quality assessment have led to heterogeneous results in terms of association with clinical data and blood glucose parameters.Aims: To investigate the sleep quality of a large cohort of adult patients with autoimmune diabetes under insulin treatment, and to analyze the ...

Background and Objective: Severe metabolic complications generally manifest at an early age in Berardinelli – Seip congenital lipodystrophy (BSCL) and their management is especially challenging, often requiring prompt pharmacological treatment with insulin-sensitizers, lipid lowering drugs, insulin and eventually metreleptin. Nutritional intervention with low lipid personalized diets is considered by experts a fundamental tool in handling the disease when associated with ...

Mitotane (MTT) currently represents the treatment of choice for adrenocortical carcinoma (ACC). Clinical evidence shows the occurrence of hypogonadism following treatment with this drug, observed more frequently in male patients. The aim of the study, therefore, was to evaluate the impact of MTT treatment on male gonadal function on adult CD1 mice. At the end of the 45 days of treatment, testes were collected for morphological examination, and a blood sample of each animal was...

Endocrine Disrupting Chemicals (EDCs) are a heterogeneous class of compounds so called for their ability to interfere with the endocrine system. These environmental pollutants are detected in different environmental matrices; they can bioaccumulate in adipose tissue and biomagnificate in food chain due to their high hydrophobicity and low water solubility1. Two EDCs usually used in the manufacture of domestic, industrial, and agricultural products are Dibutylphtalat...

Finasteride is a 5alpha-reductase (5α-R) inhibitor used in clinics to treat androgen-dependent conditions, such as benign prostate hyperplasia and androgenetic alopecia (AGA). Its use has been associated with several adverse effects, including sexual complaints. However, to date, no hypothesis to explain such adverse effects has been proposed. This is a consequence of the still incomplete knowledge of the intricate network of motivational, psychological, and molecular inp...

Objective: Our institution (University Hospital “L. Vanvitelli“ - Naples, Italy) is a high-volume (HV) center in Naples metropolitan area and many patients are referred there to repeat thyroid fine-needle aspiration cytology (FNAC) after initial FNAC performed in low-volume institutions (LV). The aims of the study were to 1) to examine the inter-observer agreement between HV and LV institutions according to the Italian thyroid cytology system, and 2) explore how the ...

Background: Thyroid dysfunctions are among the most common immune-related adverse events (irAEs) following the administration of immune checkpoint inhibitors (ICIs) for malignancies. The pathogenesis of thyroid irAEs remains unclear and the clinical course can be multifaceted.Aim: Aims of this study were a) to describe the incidence and the clinical course of thyroid irAEs b) to determine the association between thyroid irAEs and overall survival (OS).</...

Nonislet cell tumor hypoglycemia (NICTH) is a rare complication of malignancy characterized by overproduction of incompletely processed IGF-2 and subsequent stimulation of insulin receptors and increased glucose utilization. We report a patient with pancreatic adenocarcinoma with neuroendocrine differentiation who presented with NICTH and paraneoplastic hypercalcemia. A 51 year-old male was admitted to the ER for altered mental status and confusion. His blood glucose was 27 mg...