Endocrine Abstracts

Focussed radiotherapy or radiosurgery has been a disappointing alternativeto surgery as a primary treatment for pituitary adenomas. Our departmenthas delivered stereotactic multiple arc radiotherapy (SMART) through anadapted conventional linear accelerator (LINAC) for pituitary adenomas notcured by conventional therapy. We have treated 21 patients with biochemicaland/or radiological evidence of persisting disease despite maximalconventional therapy: all patients had undergone ...

The use of Sandostatin analogues for the treatment of acromegaly is now widely accepted practice for use as an effective method of reducing growth hormone levels to normal, either as primary therapy or prior to or post surgery.An audit was carried out on 11 patients who had been commenced on monthly depot injections of Sandostatin LAR over a 12 month period. Patients notes were used to obtain information regarding, date of diagnosis, presenting features/...

Pomc synthesis and ACTH secretion by the anterior pituitary are controlled by two major, opposing players namely CRH and glucocorticoids. Most studies were performed on the AtT-20 mouse corticotroph tumor cell line or Pomc-transfected cells.Aim: Aim of the present study was to evaluate the effect of CRH and DEX on Pomc expression and ACTH secretion in normal rat corticotropes in vitro.Methods: Rat anteri...

Introduction: Glucose metabolism disorder (GMD) is a classic complication of acromegaly, but its frequency varies from study to study.Aim: We aimed to analyze GMD frequency in our population, and predictive factors such as: family history of diabetes mellitus (DM), age, gender, and GH rates.Subjects and methods: It is a prospective study where 75 hypersomatotropic subjects were analyzed. They all had fasting and postprandial blood ...

Several papers show that maternal malnutrition can affect the reproductive capability of the offspring. Leptin is an important regulator of the reproductive system, however little is known about its role in the epididymis. The goal of this study was to evaluate whether the maternal malnutrition during lactation can alter the expression of leptin and its receptors in the epididymis of rats. Six rat dams were randomly assigned to the control group (C), with free access to a stan...

Introduction: Charles Bonnet syndrome is almost unknown by the endocrinologists. It is composed by visual hallucinations that do not react with the patient contrary to psychiatric hallucinations. The abnormal visions (generally hidden by patients) appear in subjects with an impaired vision of one of both eyes as in the following case:Case report: A man aged 27, was referred for acromegaly secondary to a huge invasive somatolactotrope pituitary adenomas d...

Introduction: Glucose metabolism disorder (GMD) is a classic complication of acromegaly, but its frequency varies from study to study.Aim: We aimed to analyze GMD frequency in our population, and predictive factors such as: family history of diabetes mellitus (DM), age, gender, and growth hormone (GH) rates.Subjects and methods: It is a prospective study where 75 hypersomatotropic subjects were analyzed. They all had fasting and po...

Recurrent primary hyperparathyroidism (RPHPT) is defined as hypercalcemia occurring after 6 months of normocalcemia following initial operation. The aim of this study was to analyze our experience in RPHPT.Between 1980 and 2010 33 patients (1.2%) with primary hyperparathyroidism (HPT1) were reoperated in our tertiary referral centre for recurrence of disease: 24 adenomectomies, six subtotal parathyroidectomies, two total parathyroidectomies with autotran...

Introduction: The integrated quantitative and qualitative method was used to evaluate the impact of a ten-year iodine intervention programme on school children’s health status in rural areas of Tehran.Methods: In survey, 188 students aged 6–15 years of two villages, Kiga and Ahar, were studied. These villages that are situated near the Tehran, were known for sever endemic goitre in previous studies. The clinical and biochemical measurement carr...

ObjectiveTo investigate whether salivary cortisol could provide an alternative to serum cortisol for hypocortisolaemic patients undergoing hydrocortisone day curves.MethodCorrelational study of 58 patients receiving corticosteroid replacement therapy for primary (9) or secondary (49) hypocortisolaemia. Paired samples of saliva and serum were taken at pre-determined time points throughout a 7½ hour hydroc...