Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1300 | Paediatric endocrinology | ICEECE2012

Growth and response to rhGH treatment in patients with congenital combined pituitary hormone deficiency younger than 3 years of age

Braslavsky D. , Keselman A. , Bastida G. , Bergada I.

Congenital combined pituitary hormone deficiency (CCPHD) is a rare disease.Although most of them are growth hormone deficient, growth retardation is not always the presenting symptom\. There is no normative data in children younger than 3 years regarding dose and frequency with rhGH treatment. The objective was to evaluate the timing of growth retardation and the first and second year growth response to rhGH compared to the mathematical growth prediction...

ea0029p1527 | Pituitary Clinical | ICEECE2012

Pituitary lesions: Pituitary adenomas and what else?

Vourliotaki I. , Boumpaki A. , Alexaki S. , Stamataki K.

Introduction: Pituitary lesions are quite often in the general population and can be symptomatic or not. Most are attributed to pituitary adenomas. Differential diagnosis also includes other causes, such as granulomatous diseases (sarcoidosis, histiocyttosis). Neurosarcoidosis is rare. Sarcoidosis pituitary infiltration is even more rare and usually reported in multifocal forms of the disease.Case report: We describe a 34-year old female with headache an...

ea0029p1606 | Thyroid (non-cancer) | ICEECE2012

Antigen mimicry between aeroallergens and thyroid antigens can modify the levels of thyroid hormones and antibodies in thyroid autoimmunity

Molnar I. , Kelemen E. , Somogyine-Vari E.

The allergic sensitization represents an environmental factor for thyroid autoimmunity and highlights a common pathway between autoimmunity and allergy. Elevated IgE levels are connected to hyperthyroid Graves’ disease. The allergic sensitization in thyroid autoimmunity seems mainly to be an associated immune reaction.Allergic sensitization to 20 aeroallergens and the levels of thyroid hormones and antibodies were studied in 121 patients with Graves...

ea0029p1685 | Thyroid (non-cancer) | ICEECE2012

Ultrasonographic aspects in post-partum thyroiditis

Stanciu M. , Popa F. , Totoian I.

Introduction: Post-partum thyroiditis (PPT) is an autoimmune disorder of the thyroid gland, which occurs in the first year after parturition. Post-partum thyroiditis occurs in 50% of TPO AB+ve women and is characterised by transient hyperthyroidism followed by transient hypothyroidism during the first 6 months, post-partum. A third of the latter group develop permanent hypothyroidism. The aim of this study was to evaluate sonographic characteristics in a g...

ea0029p1715 | Thyroid (non-cancer) | ICEECE2012

Study thyroid function in patients with acromegaly

Shestakova T. , Dreval A. , Ilovaiskaja I. , Zaharevich E.

Goal: Study thyroid function in patients with acromegaly. Materials and method: 88 patients with acromegaly, age 54.6±13.2 years, mediana diagnosis acromegaly 4 years, IGF1 528 (265; 701.3 ng/ml, HG 10.4 (3.7; 30.1) μE/ml, only 12 patients had a remission of disease. All patients were taken TSH, fT4, TPO antibodies, revealed anamnesis of thyroid diseases.Results: 19 from 88 patients (21.6%) had hypothyreosis and 2 (2.3%) had subclini...

ea0029p1718 | Thyroid (non-cancer) | ICEECE2012

Stessful life events and Graves’ disease

Kostoglou-Athanassiou I. , Gkountouvas A. , Kaldrymides P.

Stress appears to activate the immunoneuroendocrine network and seems to be related to the development of autoimmune diseases. Graves’ disease is a multisystem disorder characterized by hyperthyroidism, eye disease and pretibial myxedema. Stress appears also to be related to the development of Graves’ disease.The aim was to describe cases of Graves’ disease which developed immediately after a stressful life event.Pat...

ea0029p1843 | Thyroid cancer | ICEECE2012

Hyperfunctioning thyroid nodule and thyroid cancer

OliveiraFilho A. , Bezerra I. , PorDeus M. , Nunes A.

Thyroid nodules are common and majority is benign. Even so, clinicians and patient always concern about the risk for malignancy. In the past it was believed that hyperthyroidism excluded the possibility of a thyroid carcinoma. We describe here two patients presenting “hot” thyroid nodules with final diagnosis of papillary thyroid carcinoma. Informed consent was obtained. Case 1: A 39-years-old female, presenting with irritability, disquiet, and neck swelling. A nodul...

ea0026p102 | Female reproduction | ECE2011

The importance of PIK3R1 gene in polycystic ovary syndrome

Xita N , Chatzikyriakidou A , Georgiou I , Tsatsoulis A

Introduction: Insulin resistance is a main characteristic of polycystic ovary syndrome (PCOS) and contributes to the increased risk of type 2 diabetes and cardiovascular disease. It is thought that in PCOS there is an alteration in the insulin signaling pathway. An important kinase in this pathway is the phosphatidylinositol 3 kinase (PI3K), the activity of which has been found to be decreased in PCOS. Based on this observation we investigated whether a single nucleotide polym...

ea0026p103 | Female reproduction | ECE2011

Effect of paraoxonase genes on metabolic profile of women with polycystic ovary syndrome

Xita N , Lazaros L , Georgiou I , Tsatsoulis A

Introduction: Increased oxidative stress is considered to be implicated in the pathophysiology of polycystic ovary syndrome (PCOS). While the regulation of oxidative stress is multifactorial, many studies have been focused on the antioxidant role of paraoxonase (PON). The aim of this study was to investigate the possible association of the Q192R and the L55M polymorphisms of PON1 and the Ser311Cys polymorphism of PON2 with PCOS.Subjects and...

ea0026p373 | Thyroid (non cancer) | ECE2011

Risk factors for morbidity after thyroid surgery: analysis of 559 cases

Jafferbhoy S , Ramus N I , Ilyas S

Background: Surgery remains the mainstay of treatment for both benign and malignant thyroid disease. Permanent hypoparathyroidism and recurrent laryngeal nerve injury are the two most commonly occurring complications post thyroid surgery. The aim of this study is to determine the risk factors for developing post-operative complications.Methods: From January 1999 to March 2009, all patients who underwent thyroid surgery under the care of one surgeon were ...