Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep631 | Adrenal and Cardiovascular Endocrinology | ECE2024

Haematuria as an atypical presentation of pheochromocytoma: a case report

Matijaca Ana , Kujundžić Magdalena

Pheochromocytomas are rare catecholamine-producing tumors that arise from chromaffin cells located in the adrenal medulla. They are usually benign, but approximately 10% of pheochromocytomas are malignant. The most common clinical features include Menard triad: headache, sweating and palpitations, and permanent or paroxysmal hypertension. Haematuria as a presenting feature of adrenal pheochromocytoma is rarely seen. We report a case of pheochromocytoma in a 61-year-old female ...

ea0083pno5 | Pituitary and Neuroendocrinology | EYES2022

Postoperative basal cortisol level as an indicator of pituitary surgery success in Cushing’s disease treatment: a single centre retrospective study

I. D. Vodanovic , A Balasko , I. Kraljevic , A Barac Nekic , T. Dusek , D. Kastelan

Background: Pituitary surgery is the primary therapy for Cushing’s disease (CD). Basal cortisol level (BCL) is measured postoperatively to evaluate the immediate efficacy of surgical treatment, but no definitive cut-off value has yet been determined as reliable. Our pituitary-dedicated centre uses an arbitrary BCL less than 50 nmol/l as expected early remission marker, identifying all patients with higher BCL as a risk group for early surgical failure.<p class="abstex...

ea0063p909 | Diabetes, Obesity and Metabolism 3 | ECE2019

Circulating microRNAs expression profile in individuals with obesity compared to healthy controls

Assmann Tais Silveira , Milagro Fermin I , Cuervo Marta , Riezu-Boj Jose I , Martinez J Alfredo

Context: Obesity is a global epidemic and an independent risk factor for several metabolic disorders. Emerging evidence suggests a role for epigenetic factors, such as microRNAs (miRNAs), in the development of obesity. MiRNAs are small non-coding RNAs that regulate gene expression. Moreover, circulating miRNAs are potential noninvasive biomarkers because they are stable in body fluids and can be detected using validated techniques, such as quantitative PCR. However, the identi...

ea0035p503 | Endocrine disruptors | ECE2014

The reproductive toxicity of butyl benzyl phthalate in male rabbits: the possible protective role of flaxseed

Yousef Mokhtar I , El-Okazy Ahmed M , Kamel Kamel I , El-Ashmony Mohamed A M

The present study was carried out to investigate the reproductive toxicity of butyl benzyl phthalate (BBzP) on semen characteristics, hormones levels (testosterone, LH and FSH), testicular lipid peroxidation and antioxidants enzymes and histological changes in testes in male rabbits for 12 weeks. The flaxseed lignan and its mammalian metabolites have been reported to exert protective effects against diet-related chronic diseases through a variety of mechanisms including phytoe...

ea0029p63 | Adrenal cortex | ICEECE2012

Genetic, anthropometric and metabolic features of adult norwegian patients with 21-hydroxylase deficiency

Nermoen I. , Bronstad I. , Fougner K. , Svartberg J. , Oksnes M. , Husebye E. , Lovas K.

Objective: The aim of this study was to determine genetic, anthropometric and metabolic features in an unselected population of adult Norwegian patients with classical 21-hydroxylase deficiency (21OHD).Patients,Methods, and design: Sixty-four 21OHD-patients participated (23 men, 41 women; mean age 40.3 (range 19–72) in a cross-sectional study including DNA sequencing of the CYP21A1P-CYP21A2 locus, anthropometric measurements i...

ea0029p786 | Endocrine tumours and neoplasia | ICEECE2012

Screening of AIP mutations in young Romanian patients with sporadic pituitary adenomas

Baciu I. , Capatina C. , Aflorei D. , Botusan I. , Coculescu M. , Radian S.

Introduction: The pathogenesis of pituitary adenomas is incompletely understood. It was recently demonstrated that mutations in AIP, a novel tumor suppressor gene, are causing the familial isolated pituitary adenoma syndrome. Although initial data suggested that AIP mutations are rare in non-familial cases, a recent study demonstrated an increased prevalence in young sporadic macroadenoma patients.Aim: To perform a systematic screening of AIP mutations i...

ea0029p884 | Endocrine tumours and neoplasia | ICEECE2012

Special diagnostic, therapeutic and evolutive aspects of insulinoma: a tunisian experience

Oueslati I. , Kammoun I. , Riahi T. , Ouannes S. , Kandara H. , Turki Z. , Ben Slama C.

Insulinoma is a very rare type of islet cell tumor. The aim of our study is to report our clinical experience with insulinoma in order to determine clinical, biological, radiological and therapeutic particularities of this tumor type.It’s a retrospective study, including five patients (three women and two men) referred to our department between 2005 and 2011 for hypoglycemia exploration. Mean age of our group is 39.8±15.4 years (ranges: 20&#150...

ea0029p907 | Female Reproduction | ICEECE2012

Association of the (TAAAA)n repeat polymorphism of SHBG gene with age at menopause in Greek postmenopausal women

Markatseli A. , Hatzi E. , Bouba I. , Xita N. , Tigas S. , Georgiou I. , Tsatsoulis A.

Introduction: Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex steroid hormones, which in turn regulate reproductive function. The potential association of SHBG gene polymorphisms with the age at menopause has not been examined.Objective: The present study aimed to assess the possible relationship between the pentanucleotide (TAAAA)n repeat polymorphism in the promoter of the SHBG gene and the age at menopause in a Greek fe...

ea0029p937 | Female Reproduction | ICEECE2012

Hypoandrogenemia at women with hypogonadotropic hypogonadism

Ilovayskaya I. , Zekster V. , Mikhaylova D. , Goncharov N. , Melnichenko G. , Dedov I.

We estimated androgen status at 111 female patients (pts) with HH before and after hormonal therapy (HT) by estadiol 2 mg+dydrogesterone 10 mg in sequence manner not <12 months. Median age of pts was 28 y.o., mean duration of HH 6.2 year, isolated HH n=56 group 1, HH as a part of hypopituitarism n=55 group 2, 45 healthy women of the same age were included in control group. Total T, SHBG and DHEA-S levels were measured, free T levels were calculated using stan...

ea0029p1006 | Growth hormone IGF axis - basic | ICEECE2012

Association Turner's syndrome and GH deficiency

Oueslati I. , Hadj Ali I. , Khiari K. , Mchirgui N. , Ben Abdallah N.

One of the most clinical characteristic of Turner’s syndrome is the final short stature.In order to cure this handicap, several teams were interested to treat these patients by the GH.We report two cases of Turner syndrome associated with GH deficiency.In the first, a 17 years old girl, having a delayed growth lower than −4 S.D. associated with delayed puberty and dysmorphic syndrome...