Searchable abstracts of presentations at key conferences in endocrinology

ea0099p539 | Pituitary and Neuroendocrinology | ECE2024

COVID-19 and hyponatremia: from possibility to probability

Steiner Kristina , Canecki-Varžić Silvija , Schonberger Ema , Marušić Romana , Ormanac Klara , Bilić-Ćurčić Ines

Introduction: Hyponatremia is the most common electrolyte imbalance in hospitalized patients and frequent finding in intensive care units. Hyponatremia is characterized with serum sodium values less than 135 mmol/l and defined by the ratio of total sodium and total body water. It presents with lethargy, confusion, neuromuscular excitability, hyperreflexia, stupor and even coma. In addition to neurological signs and symptoms, assessment of hyponatremia is based on severity and ...

ea0099ep383 | Pituitary and Neuroendocrinology | ECE2024

Challenges in managing acromegaly: choosing the right therapeutic option

Schonberger Ema , Bilić-Ćurčić Ines , Marušić Romana , Steiner Kristina , Ormanac Klara , Canecki-Varžić Silvija

Introduction: Pituitary tumors leading to acromegaly are typically diagnosed as macroadenomas with the potential to infiltrate nearby tissues. If left untreated, acromegaly can result in systemic complications, such as hypertension, glucose intolerance, type 2 diabetes, and cardiovascular disease, leading to substantial comorbidities and a higher mortality rate.Case report: We present a case of a 57-year-old patient who initially presented in 1993 with g...

ea0099ep1035 | Pituitary and Neuroendocrinology | ECE2024

Double pituitary lesions in cushing disease – a case report

Ormanac Lara , Canecki-Varžić Silvija , Marušić Romana , Schonberger Ema , Steiner Kristina , Bilić-Ćurčić Ines

Introduction: Double and multiple pituitary adenomas (PAs) are rare in patients with Cushing’s disease. If two PAs are found, MRI cannot assess secretory activity. The claimed diagnostic effectiveness of inferior petrosal sinus sampling (IPSS) ranges from 82 to 100% across various studies. Yet, this procedure has limitations in everyday clinical practice. Thus, more clinical data on these lesions and possible advanced yet simpler diagnostical procedures are needed, as tre...

ea0101ps3-24-05 | Translational thyroid cancer research-2 | ETA2024

Potential influence of MIR-204-3P on ETS-1 protein expression in papillary thyroid carcinoma

Stojanović Stefana , Selemetjev Sonja , Djoric Ilona , Janković Miljuš Jelena , Tausanovic Katarina , Milinkovic Marija , Išić Denčić Tijana

Objectives: ETS-1 (E26 transformation-specific) is a transcription factor associated with the progression of carcinomas of various origins. Its expression in PTC is poorly described, and the findings are controversial. This study aimed to describe ETS-1 protein expression in papillary thyroid carcinoma (PTC) and to evaluate the potential influence of miR-204-3p on the ETS-1 protein expression in PTC since the bioinformatic analysis revealed that miR-204-3p shares a seed sequen...

ea0081ep11 | Adrenal and Cardiovascular Endocrinology | ECE2022

The concentration of metanephrine and normetanephrine in the most common indications for biochemical monitoring

Marušić Romana , Bačun Tatjana

Objectives: Pheochromocytomas are rare neuroendocrine tumors that originate in chromaffin cells of the adrenal medulla and excessively secrete catecholamines, which leads to a multitude of different symptoms. The most common symptoms include headaches, palpitations and sweating. Because of a diverse clinical picture, they pose a major challenge in diagnostics and often go unidentified. The diagnosis is confirmed by measuring plasma and 24-hour urinary metanephrine and normetan...

ea0081ep1134 | Thyroid | ECE2022

Severe hyperthyreosis

Petrak Iva , Zibar Tomšić Karin

A 72-year-old male patient presented to the ER because of general weakness, myalgia, frequent paroxysms of atrial fibrillation, shortness of breath, and hoarseness. The symptoms persisted for two months, gradually worsening and causing him to lose weight. At some point, he noticed redness of the sclera and soreness of the eyeballs. Paroxysms of rapid atrial fibrillation have been known for more than 15 years, so he had amiodarone in therapy. His initial laboratory findings sho...

ea0083ap2 | Adrenal and Cardiovascular | EYES2022

Autoimmune polyglandular syndrome type 1 in siblings: assembling the jigsaw puzzle

M. Manojlovic , I. Bajkin , T. Icin , K. Stepanovic , M. Lekin

Background: Autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive, monogenic disease, that could be presented as a group of various symptoms, but clinical diagnosis requires existence of minimum two of three leading disorders: chronic mucocutaneous candidiasis, hypoparathyroidism, and primary adrenocortical insufficiency.Case Presentation: We report the clinical cases of two siblings with APS-1, one 28-year-old male and one 25-ye...

ea0083ap6 | Adrenal and Cardiovascular | EYES2022

Interplay of MYC and HIF signaling in pheochromocytomas and paragangliomas: Impact on the differentiation and aggressiveness

N Bechmann , I Poser , D Stanke , G. Eisenhofer

The genetic heterogeneity of pheochromocytomas and paragangliomas (PPGL) offers opportunities to develop individualized treatment approaches for affected patients. Therefore, an improved understanding of the molecular features associated with different tumor phenotypes is required. Hypoxia-inducible factor (HIF) 2α-regulated pathways involving the MYC/MAX complex are directly linked to differentiation and aggressiveness in PPGLs. However, the distinct functions of the two...

ea0083tp2 | Thyroid | EYES2022

Unilateral Graves Orbitopathy-case report

A Stevchevska , T Milenkovic , I Mladenovska , S Jovanovska Mishevska

Background: Graves’ Orbitopathy (GO) is the most common extra thyroidal feature of autoimmune thyroid disease presentation. It is characterized by development of orbital inflammation that involves both, adipose tissue and extra-ocular muscles. The condition is associated with increased psychological burden and in severe cases may lead to optic nerve damage, causing blindness. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affec...

ea0083cbp2 | Calcium and Bone | EYES2022

Densitometry misinterpretation leading to unnecessary denosumab prescription

M Mustapic , J Andric , I Samle , V Pandzic Jaksic

Background: Bone mineral density (BMD) measurement is an important tool for fracture risk assessment, but should be used with awareness of its performance and analysis pitfalls.Case Presentation: A 59-year-old patient underwent her first densitometry as part of a routine medical check-up. She had no previous fractures and no risk factors that could impair bone health. The results showed that her BMD was in the range of low bone mass. Four years later, de...