Endocrine Abstracts

Objective: To find a relation between thyroid parameters (thyroxin serum level, thyroid antibodies, thyroid gland volume and ultrasound texture) and serum level of selenium.Background: Selenium deficiency can lead to a decrease of triiode-thyronine in peripheral tissues. Changes in thyroid hormone production can be reflected in followed thyroid parameters.Methods: In 33 patients ultrasound examination of thyroid gland was performed...

Gonadotroph adenomas are usually detected by their local mass effects. Spontaneous ovarian hyperstimulation syndrome (OHS) has rarely been described as the main manifestation of gonadotroph adenomas in young women. We present a case with a prolonged OHS occurring during IVF ovarian induction leading to the discovery of a FSH pituitary tumour.Case report: A 36 year-old, normal weight woman with 2 years primary infertility linked to oligomenorrhea and anov...

We have previously demonstrated that ERβ is necessary for embryonic development of the brain as early as E14.5 and is involved in neuronal migration. Such early effects of estrogen receptors were unexpected because estradiol synthesis and action in the brain are well documented to occur at E18.5.Since the presence of ERβ in the embryonic brain has not been demonstrated, it remained possible that the developmental abnormalities in ERβ−/− mi...

Introduction: Paragangliomas are rare neuroendocrine tumors that arise from the extraadrenal paraganglia. Sympathetic paragangliomas usually secrete catecholamines and are located in the sympathetic paravertebral ganglia of thorax, abdomen and pelvis.Case report: We present a 66 year old patient with an incidentally found retroperitoneal mass on spine MRI. An open biopsy was performed (9/15) with the histological finding of benign paraganglioma (accordin...

Pheochromocytoma is a rare neuroendocrine tumour usually formed in the adrenal medulla. Percutaneous biopsy has been associated with life-threatening haemorrhage, hypertensive crisis, capsular disruption with tumour implantation and death. We present a case of a 63 years old woman with non-specific clinical signs which included high blood pressure, headache, tachycardia and abdominal pain. She was treated for rheumatoid arthritis. Bilateral expansion of adrenal gland with dela...

Introduction: Testosterone(T) is converted to dihydrotestosterone(DHT), the most potent androgen, by the enzyme 5alpha-reductase type 2(SRD5A2). During foetal development, the masculinisation of male external genitalia crucially depends on DHT. Pathogenic variants in SRD5A2 cause 46,XY differences in sex differentiation(DSD). Early and accurate diagnosis is paramount to facilitate gender assignment since most reared as females may profoundly virilize at pubert...

Background: The nature of adrenal tumors can occasionally be difficult to determine using only laboratory and radiological findings. In those rare cases, obtaining a cytological sample by fine needle aspiration (FNA) can be valuable. Transabdominal ultrasound, endoscopic ultrasound (EUS), and computerized tomography (CT) guided biopsy are the most used methods for obtaining a cytological sample from an adrenal lesion.Methods: Adrenal FNAs performed betwe...

Adrenal tumors (ATs) are uncommon in children and adolescents. The aim of this nation-wide retrospective registry-based cohort study was to characterise the various ATs in this population and demonstrate their differences from ATs in adults. All patients under the age of 21 in Sweden with verified adrenal lesions according to ICD-codes between 2005 and 2019 were identified in linked nation-wide registries. Out of the total 232 patients, 121 (52.2%) were boys, with boy predomin...

Introduction: Thyroid function tests (thyroid hormones and thyreotropin) are frequently used by physicians all over the world. The interpretation is usually quite simple and straight-forward, however sometimes there is a strange discrepancy between the laboratory findings and clinical presentation. There are several potential explanations to this discrepancy and interference in laboratory assay may be one of them.Observation: We present a case of a 73-ye...

Introduction: Pheochromocytomas (PHEO) and paragangliomas (PGL) - (PPGLs) are neuroendocrine tumors derived from chromaffin cells of the adrenal medulla or extraadrenal nonchromaffinic tissue, respectively. PPGLs occur in 0.05% to 0.1% of patients with secondary hypertension. Chromogranin A (CgA) is the main non-specific biomarker of neuroendocrine tumors. It is produced and secreted into the blood by endo- and neuroendocrine cells of various organs (e.g., adrenal glands). The...