Endocrine Abstracts

Introduction: SARS-CoV2 infection or vaccination against SARS-CoV2 has been linked to the onset or recurrence of Autoimmune and subacute thyroiditis resulting in thyroid dysfunction.Case: We describe a case of Thyroid eye disease temporally associated with SARS-CoV 2 infection in a 48 year old female with a one-year history of subclinical hypothyroidism without interval thyroid hormone replacement or SARS-CoV2 vaccination. Two months following PCR confir...

Introduction: Thyroid dysfunction is one of the commonest endocrine disorders with hypothyroidism being the most common thyroid dysfunction in the elderly population[1]. An elderly patient with thyroid dysfunction can be asymptomatic, or present with non-specific symptoms, making biochemical testing of thyroid function useful and essential. We reviewed the screening rate and prevalence of thyroid dysfunction in older medical patient patients admitted to an Irish sec...

Background: People wanting to access gender affirming hormone therapy (GAHT) as part of gender affirming treatments are increasing in number and often face long waiting lists. Nationally there is often limited and inconsistent endocrine support for this group. As a result people often feel unsupported and confused in their treatment journey. (In 2019 we set up a dedicated endocrine clinic within the Grampian GIC (gender identity clinic), with the specific remit to see all peop...

A 51-year-old lady presented as an emergency with disabling, recurrent hypercalcaemia in July and August, 2015 with a peak corrected calcium of 3.94 mmol/l (normal range 2.2–2.6). She had been diagnosed with a stage 1A endometrial cancer, treated with hysterectomy and bilateral salpingo-oophorectomy in April 2014. Significant pelvic and left groin lymphadenopathy was noted, and was found to be enlarging on surveillance CT of July 2015. She was also found to have a left ki...

Introduction: Premature ovarian insufficiency (POI) affects approximately 1% of females. In POI, hormone replacement manages symptoms and reduces the risk of bone mineral density (BMD) loss as oestrogen acts to enhance bone deposition in bone remodelling. Oestrogen may be given either as synthetic oestrogen (ethinylestradiol) as in most combined oral contraceptives (COCP), or as physiological oestrogen (oestradiol) as in hormone replacement therapy (HRT preparations) and a sel...

Introduction: Macrohormones are complexes of monomeric hormone molecules with IgG leading to formation of macrocomplexes. They are usually immunoreactive, but biologically inactive. The higher molecular weight results in reduced renal clearance and therefore accumulation in the blood. We present two cases of unusual macrohormones.Case 1: A 55-year-old male had his thyroid function checked as part of investigation for chest pain, and was started on thyrox...

Introduction: Diabetes Ketoacidosis, DKA, is a serious condition with significant morbidity and mortality. Most DKA patients are potassium deficient, but present with hyperkalaemia due to severe acidosis and insulin deficiency. Hypokalaemia at presentation of DKA is extremely uncommon.Clinical case: A 25 year old man was admitted with severe DKA as a first presentation of diabetes. His venous pH was 6.97, bicarbonate 3.0 mmol/l, potassium 3.4 mmol/l. He ...

Introduction: GH therapy is prescribed to UK children for a variety of indications. However, no central record exists, making follow-up studies difficult.Aim: To establish an ongoing audit of UK children and adolescents newly-prescribed GH in order to i) monitor trends in prescribing practice and ii) facilitate future long-term follow-up.Patient population: UK children aged ≤16.0 years newly starting GH therapy.<p class="...

Introduction: Thyroid eye disease (TED) is a visually disabling and cosmetically disfiguring condition. There is a paucity of research on the psychosocial impact of TED. One of the aims of this research is to improve understanding of the extent and type of psychosocial distress experienced by TED patients.Method: 77 patients with TED were recruited (53 female, 24 male; aged between 25 and 73 years, average age=47.6±11.6 yrs; 58% Caucasian). Particip...

Aim: We present an unusual case of long-term accidental ingestion of androgenic steroid in a young female.Case: A 28-year-old lady presented with male pattern of hair growth, weight gain of three stones, change in voice, and secondary amenorrhea. On direct questioning she admitted she was taking ‘fat bursting pills’ for nearly 6 months, obtained from a gym, to lose weight. Examination revealed a blood pressure of 150/77 mmHg, increased muscle b...