Endocrine Abstracts

Background: The increasing prevalence of diabetes mellitus (DM) is leading to a higher number of patients with diabetic retinopathy (DR) being referred to an ophthalmologist. In order to provide better care for patients, the Department of Endocrinology at the University Hospital of Zagreb has started screening of the ocular fundus.Objectives: The aim was to present the results of screening on DR in a random sample of DM patients and to compare the result...

Testosterone deficiency syndrome (TDS) may well contribute to a number of co morbidities and multitude of symptoms which may affect one’s daily activities adversely. TDS prevalence in UK is 1:500 and certain groups of patient’s are at higher risk of TDS, in particular elderly and patients with diabetes mellitus where 42% are known to have TDS. A retrospective audit was carried out to bench mark our practice in line with a publication of a recommended National/Europea...

Background: The aim of this study was to explore if evaluation of lipid risk factors like Lipoprotein(a) (Lp(a)) and conventional lipid profile parameters can be a efficient predictor of the cardiovascular risk in the patients of Diabetes.Methods: Sixty individuals with angiographically proven premature CAD and 30 healthy individuals matched for age and sex were studied a tertiary health care centre, New Delhi, India, over a period of 18 months. CAD pati...

Background: The aim of this study was to explore if evaluation of lipid risk factors like Lipoprotein(a) (Lp(a)) and conventional lipid profile parameters can be a efficient predictor of the cardiovascular risk in the patients of Diabetes.Methods: Sixty individuals with angiographically proven premature CAD and 30 healthy individuals matched for age and sex were studied a tertiary health care centre, New Delhi, India, over a period of 18 months. CAD pati...

A 32-year-old gentleman, of South-Asian origin was admitted with a 4-week history of abdominal pain, nausea and vomiting. He also had history of polyuria, polydipsia and weight loss over 6 weeks. Just prior to these symptoms he had been started on colecalciferol 20 000 units weekly by his GP for Vitamin D deficiency (25(OH) Vitamin D – 10.3 nmol/l (48–145)). On admission he had adjusted calcium of 4.52 mmol/l and acute kidney injury with his eGFR being 38 ml/min per ...

A 37-year-old gentleman was admitted following a GP referral for asymptomatic hypercalcaemia. His adjusted calcium was raised at 3.27 mmol/l while phosphate level was normal. The only past medical history was borderline hypertension which was being monitored in primary care. His PTH level was suppressed at 0.43 pmol/l l (1.1–5.5) while 25(OH) Vitamin D was normal at 71.6 nmol/l (48–145). Twenty-four hours urinary metadrenalines were normal. His full blood counts were...

Kisspeptins are the product of the KiSS-1 gene, a metastasis suppressor gene, and play important physiological roles in the hypothalamo-pituitary gonadal axis and reproduction. It was reported that kisspeptin-10 stimulated the aldosterone synthesis in H295R human adrenal cancer cells (Nakamura et al., 2007). However, expression of kisspeptin and its receptor has not been studied in tumor tissues of adrenocortical tumors. The aim of the present study was therefore to clarify ex...

Background: Parathyroid carcinoma is a very rare cause of primary hyperparathyroidism. We aimed to present a case of middle-aged man, who was initially misdiagnosed as parathyroid adenoma, with parathyroid carcinoma and severe bone deformities associated with hyperparathyroidism.Case: A 36-years old male presented with leg aches and severe hypercalcemia in 2001, when he was diagnosed with primary hyperparathyroidism (corrected serum calcium 18.5 mg/dL (8...

The early diagnosis of 47XXY- Klinefelter syndrome (KS) associated with infertility confronts the parents with concerns about their child outcome on cognitive, social skills and sexual identity. Few studies relate the weakness of intelligence, mainly verbal, and relational inhibition. Androgen may be offered to adolescents to normalize anatomic and psychic puberty processes. This has never been evaluated in psychological terms.Subjects and methods: Eight...

Objective: Estrogen receptors α and β are members of the nuclear receptor family which regulate target gene expression in response to estrogens and to growth factor receptors-mediated pathways. CXCR4 is a chemokine receptor whose physiological ligand is the stromal-derived-factor-1 (SDF-1), a chemokine with proliferative and chemotactic functions. Recently, we reported that ERβ activity can be modulated by the tyrosine kinase ErbB2/ErbB3 receptors and also by th...