Endocrine Abstracts

Background: More than 12,000 people in the United States are diagnosed with a NET each year and approximately 175,000 people are living with this diagnosis. Little progress has been made in the therapy of NETs over the last two decades, and identification of new vulnerabilities remains a priority.Methods: We used two libraries of compounds selected for potential repurposing and identified agents with the highest cytotoxic activity in neuroendocrine model...

Background: High-specific activity iodine-131 metaiodobenzylguanidine (HSA I-131 MIBG; AZEDRA®) is the only FDA approved systemic treatment for locally advanced or metastatic pheochromocytoma or paraganglioma (PPGL). We have previously described pivotal study efficacy data that served as the basis for HSA I-131 MIBG approval demonstrating improvements in blood pressure control, objective tumor responses, and biomarker responses. Here we provide the results from a European...

Background: Despite the superiority of 68Ga-DOTATATE PET/CT in the detection of neuroendocrine tumors, the clinical impact of using this imaging modality in surgical and medical oncology practices in the United States is not well established. Here we evaluate the impact of 68Ga-DOTATATE PET/CT imaging in the diagnosis and management of patients with GI and pancreatic NETs at the University of Rochester Medical Center.Methods: Single...

Background: Incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEMs) is increasing, but etiology of sporadic, non-familial disease remains obscure. Behavioral risk factors like smoking and alcohol consumption may be associated with GEP-NENs, yet environmental factors potentially associated with GEP-NENs remain unexamined. We regressed age-adjusted incidence rates for GEP-NENs cases in California (CA) on county-level pollution data to determine if an association ...

Background: Paltusotine is an investigational oral, once-daily, small molecule somatostatin receptor type 2 agonist in development for the treatment of acromegaly and carcinoid syndrome associated with neuroendocrine tumors.Methods: This multicenter, open-label, phase 1 study enrolled participants with mild, moderate, and severe hepatic impairment based on Child-Pugh classification and matched healthy participants. A single 20-mg oral dose of paltusotine...

Introduction: Thyroid carcinoma accounts for 1% of all thyroid tumours. Bone metastasis occurs in 10 to 40%, with skullmetastasis accounting for 2.5 to 5.8% of bone metastases. The largest series of skull metastasis from thyroid carcinoma described a frequency of only 2.5% among 473 patients. The majority of skull metastasis from thyroid cancers is of the follicular subtype. She can occur at any age, the youngest patient was just 18 years old but most patients are between 60 a...

Neuromyelitis Optica (NMO) is a neuro-inflammatory condition usually presenting with optic nerve and spinal cord events, caused by autoimmunity to Aquaporin 4 (AQ4) channels in the central nervous system (CNS). The high density of AQ4 channels in the hypothalamus and area postrema mean that NMO can occasionally present with atypical features. We present a 56-year old South Asian man, who presented with hiccoughs and Syndrome of inappropriate antidiuretic hormone (SIADH ) and w...

Phytoestrogen genistein is one of the endocrine disrupting chemicals found mostly in soybean. It has become a topic of interest since decades ago in view of its benefits in reducing the risks of breast cancer, cardiovascular disease, obesity and perimenopausal symptoms. However, it has been reported that genistein can cause adverse consequences on female reproductive system and may cause infertility. Its action was said to be associated with its binding affinity to oestrogen r...

An asymptomatic 66-year-old man was referred for investigation of chronic hypernatraemia. Plasma sodium varied between 146–152 mmol/l and potassium was normal over several years. There was no relevant past, family or drug history. There were no symptoms or signs of hypercotisolism or other endocrinopathy either. Clinical examination was normal.Initial investigations were as follows – sodium 149 mmol/l, potassium 4.3 mmol/l, urea 7.9 mmol/l, cre...

Aim: Previous studies demonstrated lower serum zinc among prediabetics and diabetics, compared to normoglycaemics. There is no current epidemiological data available in regional Australia examining the association between serum zinc and glycaemic status. This study was conducted to determine the relationship between serum zinc, glycaemic status and Homeostasis Model Assessment (HOMA-2) parameters in a regional Australian hospital population.Methods: A re...