Endocrine Abstracts

Rationale: Pituitary tumours (PiTs) are a common and heterogeneous group of benign, slow-growing intracranial neoplasms arising from the sellar region. While recent advances have improved our knowledge of their cellular composition and the contribution of their tumour microenvironment (TME), most of PiT subtypes lack effective therapeutic treatments. Moreover, the mechanisms that occur in the early stage of PiT initiation remain to be elucidated partly due to the limited numbe...

Introduction and objectives: Diabetic ketoacidosis (DKA) is a severe acute complication of Diabetes Mellitus (DM) and may require hospital admission. Our aim was to compare the characteristics of DKA occurring in patients with autoimmune DM (AMD) and type 2 DM (DM2) in our setting.Methods: Retrospective observational study. Patients with AMD and DM2 admitted for DKA at the Hospital Universitario San Cecilio de Granada between January 2019 and December 20...

Introduction: Obesity is a known risk factor for hypovitaminosis D and although several studies point out that higher adherence to the Mediterranean Diet (Diet-Med) is associated with higher dietary vitamin D intake, there are very limited data on the influence of Diet-Med on serum 25-Hydroxy Vitamin D (25OHD) levels. Our aim was to evaluate the relationship between adherence to Diet-Med and vitamin D status in obese patients.Material and Methods: Retros...

Introduction and Objectives: Continuous glucose monitoring (CGM) has demonstrated benefits in the prevention of hypoglycemia in patients with type 1 diabetes mellitus (DM1) vs flash monitoring (CGM). Our aim was to analyze the clinical characteristics, indication and glucometric changes in patients using MFG after CGM implantation.Material and methods: Retrospective observational study of 13 patients under follow-up for DM1 in Endocrinology consultations...

Introduction: Hypophysitis is a rare disease. Lately, it is more frequent due to the use of Inmune Check Point Inhibitor (ICPIs). Ipilimumab or combo Ipilimumab + Nivolumab are the main cause. Agree with literature, 17-18% of the patients with these drugs suffer from. By contrast, with Idiopatic Autoimmune Hypophysitis and Lymphocytic Hypophysitis, this type of hypophysitis occurs in sixties men. Autoinmunity mechanism is known, but precise pathophysiology is unclear <p cl...

Objective: Endogenous cushing syndrome (ECS) is a complex and rare disease. After treatment, 50% of cases have recurrence. The objective is to evaluate the prevalence of recurrences in patients diagnosed of ECS and its predictive factors.Materials and Methods: Analytical retrospective observational study with 19 ECS diagnoses cases followed-up from January 1999 to December 2023. Demographic (sex, age), clinical (cause, face plethora, fragile capillary, r...

Craniopharyngiomas (CPs) are a relatively benign subtype of epithelial tumors that typically originate from the sellar and suprasellar regions of the brain. These endocrine tumors are classified as adamantinomatous (ACP) or papillary (PCP) based on their histological characteristics. Unfortunately, the diagnosis of CPs is frequently made at an advanced stage of tumor development, and therefore relevant associated comorbidities are often present. The first-line treatment is typ...

Introduction: In May 2020, during the COVID-19 pandemic, the Spanish Group of Diabetes and Pregnancy published a consensus document establishing the alternative diagnostic criteria for gestational diabetes mellitus (GDM) in case of impossibility to perform the two-step traditional approach due to the COVID-19 sanitary emergency. This study aims to compare different characteristics of pregnant women who tested positive in the O’Sullivan test in the same pregnancy trimester...

Corticotrope cells give arise to utmost aggressive and to very rare pituitary neoplasias, including pituitary carcinomas, Crooke’s cell adenomas (CCA), clinically non-functioning silent corticotrope adenomas (SCA) and the Cushing-provoking pituitary adenomas (CD). The molecular etiopathogenesis of these tumors are still poorly understood. Therefore, we carried out whole exome sequencing to better understand the full genomic landscape single nucleotide variants and copy nu...

Introduction: Because of the increase of brain image explorations, the prevalence of pituitary tumours has increased a lot. Although most of them have an indolent behaviour, some behave aggressively, demanding a lot of resources for their management. Therefore, it is very important to identify them as soon as possible. The recent WHO 2017 classification of pituitary tumours gives insights into improving their identification using the immunostaining (IS) of transcription factor...