Endocrine Abstracts

Introduction: Despite the significant associated cardiovascular morbidity, as well as the significant economic implications, little consideration has been given towards population screening for the Metabolic Syndrome (MetS). Therefore, we wished to estimate the prevalence of MetS, using both the recently published IDF, as well as the previously defined Cholesterol Education Program Adult Treatment Panel III (ATPIII), criteria. Additionally, we hypothesised that simple, inexpen...

Objective: The use of contraceptives has been reported to interfere with absorption of micronutrients many of which serve as dietary antioxidant. The Changes in antioxidant levels may play significant role in the risk and pathophysiology of diseases associated with the use of contraceptives. This study was designed to assess the comparative antioxidant status of women on oral contraceptive pills (OCP), Injectables (INJ), Intrauterine Contraceptive Devices (IUCD) and Norplant (...

Introduction: In our centre prior to 2003, testosterone implantation was undertaken by rotational junior medical staff. A specialist nurse role in testosterone implantation was developed within the Oxford Department of Endocrinology over a nine month period.Aim: To assess the adverse effects and the complications from testosterone implants offered by a specialist nurse committed to this task.Method: Since 2003, 200 implants have be...

A pre-diabetes state, Impaired Glucose Tolerance (IGT), is recognised as a natural stage in the development of diabetes with blood glucose levels gradually rising over time until levels consistent with diabetes are reached. In addition, people with IGT have a 2–3 times greater risk of macrovascular disease than euglycaemic subjects. Three recent studies demonstrate benefits of intensive lifestyle modification in people with IGT in preventing diabetes. Hence, education of ...

Apolipoprotein (Apo)-B is a strong predictor of coronary risk in the general population. Whether it contributes to coronary disease in patients with reduced kidney function is unclear. We examined the prevalence and relationship of Apo-B with physician-diagnosed myocardial infarction among 7,404 adults age >20 years with reduced glomerular filtration rate (GFR) in the U.S. population. GFR was estimated Modification of Diet in Renal Disease Study (MDRD) equation and calibra...

Alternative treatments for thyroid disorders include animal thyroid extract and preparations containing iodine. These treatments can affect thyroid status and their use may be unrecognised by doctors treating patients with thyroid disorders. We aimed to determine the nature, availability and use of alternative treatments for thyroid disorders (ATTDs).Patient questionnaires were administered to all patients with a diagnosis of a thyroid disorder attending...

Co-existence of a brain tumour (not associated with previous irradiation) and a pituitary adenoma has been rarely described. Astrocytomas have an incidence of <5/100,000 and somototroph adenomas of <4/1,000,000. In astrocytomas, a positive correlation between IGF-I immunoreactivity and histopathological grade/cell proliferation rates have been proposed. Here, we report a case of acromegaly detected incidentally shortly after the diagnosis of an anaplastic astrocytoma.<...

Aim of the study: Our study was designed to determine the possible role of phytoestrogens with minerals Ca, Mg, Zn and vitamins D, C, K in the reduction of bone mass lost in postmenopausal women.Subjects and methods: The study population consisted of 86 nonsmoking 60…80 years old women. Their bone mineral density (BMD) was measured by dual energy X-ray absorptiometry (DXA) region L2-L4. The osteoporosis had been diagnosed (T-score by DXA was &#8722...

ACTH-independent micronodular adrenocortical hyperplasia is a rare cause of Cushing syndrome. In some forms of micronodular adrenal disease, darkly pigmented micronodules are seen in the presence of atrophy of the peripheral adrenal tissue. In most cases of pigmented micronodular hyperplasia Carney complex is associated with the disease. Here, we present a case of Cushing syndrome due to sporadic primary pigmented micronodular hyperplasia not accompanied by Carney complex....

A 27-year-old woman with Carney Complex, with inactivating mutation of the PRKAR1α gene [(a 2-bp deletion of nucleotides T and G at positions 576 and 577 with frame-shift mutation beginning with aminoacid residue threonine 163 (ΔFSterThr163)], bearing a GH secreting microadenoma, Cushing syndrome from PPNAD and with high operatory risk because of the neurological sequelae of cerebral embolism from atrial myxomas, underwent a low-dose mitotane (MT) regimen.<p clas...