Searchable abstracts of presentations at key conferences in endocrinology

ea0065p155 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Carney’s triad due to SDHA gene mutation

Arabi Noon , Healy Ultan , Pal Aparna , Jafar-Mohammadi Bahram , May Christine

Carney’s triad; a diagnosis based on the presence of three associated neoplasms; epithelioid leiomyosarcoma, pulmonary chondroma, and extra-adrenal paraganglioma remains a rare diagnosis. Here we report a 52-year-old female investigated for chronic cough. Initial chest X-ray demonstrated calcified masses, and CT thorax confirmed a left pulmonary lesion measuring 41 mm in diameter with 3 adjacent smaller nodules up to 20 mm. A chondroid pattern o...

ea0066oc8.4 | Oral Communications 8 | BSPED2019

Optimising transition care in endocrinology: an example of patient-focused quality improvement

Makaya Taffy , Pal Aparna , Anderson Gemma , Loo Helen , Ashraf Muhammad Masood

Introduction: The importance of good transition care has been highlighted by NICE and NHSI. Over the last 5 year we have focused on transforming our endocrine transition service.Background: Our centre took part in the BSPED/BES-led 2014 National Adolescent Care and Transition Audit of Young people with Hormone Conditions. From this we identified key areas for service improvement including: families wanted to establish a better relationship with and have ...

ea0063p18 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Evaluating the applicability of urinary miR-483-5p as a non-invasive marker in adrenocortical cancer patients

Decmann Abel , Bancos Irina , Thomas Melinda A , Turai Peter , Perge Pal , Toth Miklos , Patocs Attila , Igaz Peter

Introduction: Minimally invasive blood-borne circulating microRNAs might be used for the preoperative differentiation of adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA). Circulating hsa-miR-483-5p is so far the best microRNA biomarker of ACC. To the best of our knowledge, there have been no studies concerning the potential applicability of urinary has-miR-483-5p as a non-invasive biomarker of ACC and its correlation with plasma hsa-miR-483...

ea0059p133 | Neuroendocrinology and pituitary | SFEBES2018

Characterisation of paediatric craniopharyngiomas in a single centre study – analysis of factors affecting recurrence rates

Rogers Miranda , Davies Dawn-Marie , Halliday Jane , Pal Aparna , Marland Anne , Foord Tina , Jafar-Mohammadi Bahram

Craniopharyngioma is a rare benign pituitary tumour that occurs in children and adults. Recurrence rates are high (up to 90%) but factors underpinning this are unclear, particularly in cases of childhood onset. We aimed to investigate factors that may influence subsequent recurrence rates in childhood onset craniopharyngiomas in patients attending our centre. A retrospective study of patients followed up at the Oxford Late Effects of Childhood Cancer service was conducted. Pat...

ea0059p136 | Neuroendocrinology and pituitary | SFEBES2018

Recovery of the hypothalamic-pituitary-adrenal and thyroid axes up to 12 months following trans-sphenoidal adenomectomy

Gunatilake Sonali , Pofi Riccardo , Macgregor Victoria , Cudlip Simon , Jafar-Mohammadi Bahram , Tomlinson Jeremy , Pal Aparna

Background: Hypopituitarism is a potential complication of trans-sphenoidal adenomectomy (TSA). Recovery of pituitary function can occur, and reassessment is required to avoid unnecessary hormonal replacement. However, frequency of re-testing is variable across centres. Aim of this study was to determine recovery rates and time to recovery of hypothalamo-pituitary adrenal (HPA) and thyroid axis after TSA.Methods: We performed a single-centre, retrospecti...

ea0059ep74 | Neuroendocrinology and pituitary | SFEBES2018

A rare case of prolactin secreting pituitary carcinoma with extra-cranial metastasis

Saeed Tamar , Halliday Jane , May Christine , Pal Aparna , Ansorge Olaf , Cudlip Simon , Jafar-Mohammadi Bahram

We present a case of 71-year-old gentleman who presented with bitemporal hemianopia in 2008 with pituitary apoplexy compressing the optic chiasm. Prolactin was 55287MU/l, with deficiency of all other anterior pituitary hormones. He underwent transphenoidal adenectomy (TSA). Prolactin was 35633MU/l post-operatively and cabergoline was commenced. Histology was consistent with a lactotroph adenoma with MiB-1 index of 3–5%. Visual fields recovered and prolactin was normal unt...

ea0037oc9.1 | Adrenal 2 | ECE2015

Effects of dexamethasone and adrenocorticotropin on circulating microRNA expression in humans

Igaz Ivan , Nyiro Gabor , Nagy Zoltan , Perge Pal , Toth Miklos , Racz Karoly , Igaz Peter , Patocs Attila

Objective: MicroRNAs are short non-protein coding RNA molecules involved in the regulation of numerous homeostatic processes via modulating gene expression. There are some data that the expression of microRNA might be modulated by hormones, but the interaction of hormones and circulating microRNAs of adrenocortical origin is mostly unknown.Methods: The expression of six selected circulating microRNAs (hsa-miR-27a, hsa-miR-125b-2, hsa-miR-200b, hsa-miR-21...

ea0035p630 | Female reproduction | ECE2014

Expression of P450arom mRNA in the ovary and brain of Indian teleosts, Labeo rohita and Anabas testudineus: seasonal variation and effects of gonadotropin

Moulik Sujata Roy , Pal Puja , Majumder Suravi , Mallick Buddhadev , Mukherjee Dilip

The cyp19 encodes cytochrome P450aromatase, the key enzyme catalyzing the conversion of androgens to estrogens. Estrogens play a critical role in controlling functional, behavioral and physiological aspects of sexual development both in males and females. Except in Anguilla anguilla, most teleosts studied so far possess two cyp19 genes namely, cyp19a and cyp19b; ovary- and brain-specific respectively. In the present study made in tw...

ea0035p858 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

A case of IgG4-related xanthomatous hypophysitis

Csajbok Eva , Magony Sandor , Sepp Krisztian , Valkusz Zsuzsanna , Barzo Pal , Tiszlavicz Laszlo

Introduction: Hypophysitis is an inflammatory disease of the pituitary that may mimic tumors. Primary hypophysitis has been classified as lymphocytic (LH), granulomatous (GH), and xanthomatous (XH). It has been recently proposed to be an IgG4-related autoimmune disease (serum IgG4 concentration: 135 mg/dl), proven by tissue IgG4 immunostaining.Case description: A 23-year-old men suffered from typical cluster type headache. Two years after the first sympt...

ea0058p020 | Growth | BSPED2018

The challenges of managing pituitary gigantism

Bendor-Samuel Owen , Pal Aparna , Cudlip Simon , Anderson Gemma , Salgia Sanjay , Makaya Taffy

Introduction: Pituitary gigantism is a rare but clinically significant paediatric condition. Transphenoidal surgery is the treatment of choice, however medical treatment is often considered as adjuvant therapy.Case report: A 10.6 year old boy presented with tall stature. With hindsight he was noticeably tall from age 5 years. At 10 years his height velocity was 12 cm/year, prompting referral and further investigation. His height was 178.7 cm (+5.79 sds a...