Endocrine Abstracts

Introduction: Vasoactive intestinal peptide-producing tumours (VIPomas) represent a rare type of neuroendocrine tumour whose incidence is 1 in 10 million per year. Most are located in the pancreas. They cause diffuse watery (secretory) diarrhoea, hypokalaemia and achlorhydria and also appear as an uncommon cause of hypercalcaemia.Case report A 69-year-old female with previous diagnosis of a ‘non-functioning’ neuroendocrine pancreatic tumour (20...

Prevalence of hyperandrogenism (HA) and polycystic ovary syndrome (PCOS) in female to male transsexuals (FMT) is controversial. To known the prevalence of hyperandrogenism and PCOS in FMT, and their relation with insulin resistance (IR) and other cardiovascular risk factors (CVRF), we studied 77 Spanish consecutive FMT cases, the first ones who appeared in our Gender Unit between May 2007 and Dec 2008, aged 18–43 years. The subjects had never received hormonal treatment o...

Aim: To assess ET1 levels in diabetic patients with and without microangiopathy, and compared with normal subjects, nondiabetic, without underlying vascular pathology.Introduction: The pathophysiology of diabetic microangiopathy is complex and many important aspects of it still are not fully understood. Endothelial dysfunction is of major importance in the pathogenesis of atherosclerosis and diabetic angiopathy. ET-1 is one of the most potent vasoconstri...

Objective: To analyze the impact of a specialized management on cardiovascular risk at the onset of type 2 diabetes mellitus.Material and method: Were analyzed 171 patients who visited our diabetes day hospital (DDH) during 2010–2011, studying the following variables: sex, age, BMI, smoking habit, arterial hypertension (de novo/previously known), antihypertensive therapy, dislypidemia (de novo/previously known), hypolipidemic thera...

Objective: To analyze the demographic and clinical characteristics of the patients treated at the onset of type two diabetes mellitus in our DDH.Material and method: During 2010–2011 were analyzed 171 patients treated in our DDH, studying the following variables: sex, age, BMI, waist circumference, family diabetes history, microvascular and macrovascular long-term complications, smoking habit, rate of associated hypertension (de novo/ previ...

Objective: Analyze the use of DPP-4 inhibitors (iDPP4) in a specialized consultation as well as metabolic impact, weight and safety in patients with diabetes mellitus type 2 (DM2).Material and methods: We analyzed 100 patients with DM2, derivative to Diabetes hospital with debut or poor glycemic control. We initiated them sitagliptin 100 mg/day and reinforced Diabetes education. We studied the HbA1c, weight and severe hypoglycemia. Statistical analysis w...

Objectives: Evaluate the impact of the therapy with GLP-1 analogues (exenatide) toguether with basal insulin in glycemic control and weight of patients with type 2 diabetes mellitus poorly controlled.Materials and methods: We analyzed 37 patients with type 2 diabetes with poor glycemic control and obesity, treatment with exenatide and basal insulin. As pre-treatment 56.7% of our patients were with basal insulin, 10.8% with insulin mixtures and 32.4% with...

Moderately elevated body iron stores may be associated with several components of the metabolic syndrome (MetSyn). Elevated serum ferritin levels (Fer) independently predicted incident type 2 diabetes in prospective studies in apparently healthy men and women.Aims: To analyze the association between Fer and components of MetSyn in transsexuals before and after 2-year cross-sex treatment (CST).Methods: Before starting the CST in 90 ...

Elevated serum ferritin levels has been reported in premenopausal women presenting polycystic ovary syndrome (PCOS) and hyperandrogenism, and thus may be involved in the development of insulin resistance, type 2 diabetes y cardiovascular disease. In female-to-male transsexuals (FMTs) PCOS is frequent and this issue has been little studied.Aims: To study the serum ferritin in FMTs with PCOS and their relations with markers of insulin resistance (IR) and m...

Objectives: Obesity and type 2 diabetes mellitus (DM2) are risk factors for non-alcoholic fatty liver disease (NAFLD). The main objective was to study the incidence of NAFLD using the Hepatic Steatosis Index (HSI) in obese patients with DM2. Secondary objectives were to analyse the effect of liraglutide over HSI, body mass index (BMI) and glycated hemoglobin (HbA1c).Methods: Retrospective observational study of obese type 2 diabetic patients treated with...