Endocrine Abstracts

Background: A 17 alpha-hydroxylase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia (CAH). Congenital adrenal hyperplasia (CAH) is a group of disorders resulting from defect of one of enzymes necessary for biosynthesis of cortisol.Case Report: A 33-year-old female suffered from 17OHD. She presented with primary amenorrhea, lack of secondary sexual characteristics, and hypertension complicated by ruptured cerebral aneurysm. Laboratory t...

Introduction: Congenital Adrenal Hyperplasia (CAH) are any of several autosomal recessive diseases resulting from mutations of genes for enzymes mediating the biochemical steps of production of mineralocorticoids, glucocorticoids or sex steroids from cholesterol by the adrenal glands (steroidogenesis).Case Report: We describe a case report of a 20 year-old female with congenital adrenal hyperplasia (CAH). The 20-year-old female patient was born with geni...

Introduction: Vitamin D deficiency is a common clinical finding in the general population and hospitalized patients, including patients in the intensive care unit(ICU). Acute kidney injury (AKI) occurs in more than 50% in ICU admitted patients.Objectives: Due to the fact that there are few studies about AKI in COVID-19 patients, we investigated the relationship between vitamin D3 deficiency and the occurrence of AKI in COVID-19 patients.<p class="abs...

Introduction: Diabetic foot osteomyelitis is a frequent complication of a preexisting infected foot wound. It is mostly the consequence of a soft tissue infection that spreads into the bone thus increasing the risk of amputation and the burden of foot care. The aim of this work is to describe the clinical and therapeutic aspect of diabetic foot osteomyelitis in our department.Patients and Methods: It’s a retrospective and descriptive study conducted...

Introduction: Sinonasal neuroendocrine carcinoma SNECs are a rare group of neoplasms that account for only 5% of all sinonasal malignancies. SNECs are categorized by their differentiation grade into well-, moderately- and poorly differentiated.Case report: We describe a classical case of SNEC with secondary orbital involvement in a 34-year-old male patient presented of the occurrence of a right epistaxis. First of all, the patient is smoking. The beginni...

Introduction: A third of pituitary adenomas are non-functioning. Classification depends on adenohypophyseal hormones expression and transcription factors.Aim: Characterize silent pituitary macroadenomas cases regarding their clinical data, treatment, histopathology and prognosis.Methods: We revised clinical process of patients followed in CHULC. Cases with non-access to clinical follow-up registries or exams were excluded.<p cl...

Introduction: Pasireotide long acting release (LAR) is approved for second line treatment of acromegaly. We present 3 patients with aggressive acromegaly treated with a personalized de-escalation approach.Case 1: A 61-year-old female affected by acromegaly reisistant on first-line SSAs. In 2015 therapy was switched to pasireotide LAR 60 mg every 28 days. After two years, the IGF-I level touched the lower age range and therapy was downscaled to pasireotid...

Introduction: Carotid body tumor is a hypervascular tumor with multiple feeding arteries and unique orientation at the carotid bifurcation. Although resection is a radical therapy for this tumor, complete resection is challenging.Case report: A 33-year-old female patient consulted with a neck swelling that had persisted for 3 years. On physical examination, a movable and pulsating hard mass was found on the left side of her neck. Computed tomography, mag...

Introduction: Hypopituitarism is a rare diagnosis that is mainly due to primary pituitary neoplasms and their treatment. There are rarer causes such as hemorrhage/ischemia, traumatic brain injury, infections and infiltrative lesions. Clinical case: We herein present an 18-year-old male patient diagnosed with acute promyelocytic leukemia at the age of 14, with no evidence of central nervous system invasion in several lumbar punctures during his follow-up....

Introduction: Cushing disease is the most common cause of endogenous hypercortisolism. Pituitary surgery is the first-line treatment and bilateral adrenalectomy is the option of last resort due to its severe consequences.Observation: This is a 24-year-old patient followed for cushing disease revealed by a severe cushing syndrome, a urinary cortisol at 20 times normal and negative dexamethasone suppression test with a pituitary microadenoma on MRI. He was...