Endocrine Abstracts

Although obesity is a powerful risk factor for developing metabolic syndrome (MetS), it is not present in all obese individuals. Increased visceral adipose tissue is the hallmark of this syndrome. In this cross sectional survey abdominal bioelectrical impedence was used to measure the visceral adipose tissue (VAT) and trunk fat percentages (TF%) in participants. A total of 286 patients (196 female and 90 males) were enrolled in the study. In both sexes VAT was significantly po...

Objective: Relationships of blood circulating melanocortins to childhood obesity are not well established. We evaluated serum α-melanocyte stimulating hormone (α-MSH) in lean children and different study groups of childhood obesity.Methods: We examined serum α-MSH in 52 otherwise healthy children with childhood obesity (Ob, mean age 11 years, 32 girls / 20 boys), 27 normal-weight children of same age, 7 additional obese patients with reduc...

Aim: We aimed to compare the cut off values, defined to express the excess total body fat (TBF) percentange and increased fat mass index (FMI) as predictors of metabolic syndrome (MS).Subjects and methods: A total of 162 obese (body mass index (BMI) >30 kg/m2) subjects’ TBF were measured by ‘Tanita TBF 300 Body Composition Analyzer’. Patients were divided into two groups called normal obese (NO) and fatty obese (FO) accordin...

Despite high survival rates (92%) in patients with childhood craniopharyngioma (CP), quality of life (QoL) is frequently impaired due to sequelae such as severe obesity resulting from hypothalamic involvement of CP. Based on the results of the multicenter prospective study KRANIOPHARYNGEOM 2000 radical surgery is no appropriate treatment strategy in patients with hypothalamic involvement. Furthermore, tumour progression/relapses are frequent early events in CP patients. The an...

Congenital morphological alteration of pituitary gland is a rare disease often associated with isolated or multiple hormonal deficiency. So far only few genes have been shown to be implicated in a small number of these cases.Aim of this study was to evaluate putative genetic alteration by an array-based comparative genomic hybridization (array-CGH) in 19 adulthood patients, 16 males and 3 females, affected by congenital morphological alteration of the pi...

Acromegaly and hypogonadism represent independent cardiovascular risk factors, worsening either different metabolic parameters or quality of life (QoL).In our cohort of 41 acromegalic males (20–82 years), 35 resulted affected by hypogonadotropic hypogonadism, while only six were eugonadal. Twenty-nine out 35 had low testosterone levels at diagnosis and six developed a post-surgical hypogonadism (testosterone cut-off: 350 ng/dl). Among hypogonadal su...

Background: Copeptin (CP), a derivate from the antidiuretic hormone (ADH) precursor pre-pro-vasopressin, stochiometrically mirrors ADH secretion. CP is increasingly evaluated as a diagnostic and prognostic biomarker in different diseases. It is therefore important to recognize possible confounding factors when interpreting CP levels. In healthy regularly menstruating women, there is a small but measurable physiological variability of hormones involved in fluid regulation. ADH ...

An atypical form of resistance to thyroid hormone (RTH) leads to retarded growth and bone age in humans. Aberrant thyroid hormone levels (high T4, low T3, elevated rT3 and high/ normal TSH) indicate a defect in deiodinase-dependent thyroid hormone metabolism. Findings of reduced concentrations of plasma selenoproteins (SePP, GPx3) suggested a generalized defect of selenoprotein biosynthesis and led to the identification of mutations in the SECISBP2 gene. SECISBP2 is thought to...

Multidimensional studies of medical aspects of ageing were performed in 6 provinces of Poland, the protocol included cross sectional analysis of thyroid function parameters.The sample was randomly chosen and included 4,051 respondents (49.2% females).Group consisted of 3,502 elderly subjects aged 65–90+y, divided into approximately equal six age subgroups; and 549 younger cohort, aged 55–59 y.Thyroi...

Introduction: Factors affecting health related quality of life (HRQOL) in Hashimoto’s thyroiditis (HT) are controversial and research on the topic is limited. This study aimed to evaluate the factors that may affect HRQOL and admitting symptoms in a group of patients with HT.Methods: For the evaluation of HRQOL, SF-36, Beck anxiety scale and Beck depression scale were performed on subsequent 57 cases with HT admitting to outpatient clinic of Endocri...