Endocrine Abstracts

Introduction: of non-functioning pituitary macroadenomas are associated with hyposecretion of the pituitary gland. In addition surgical therapy can lead to a partial or complete hypopituitarism. Data suggest that substitution of growth hormone can improve quality of life and reduce associated symptoms. However in many cases substitution is not started within the first 6–12 months after surgery. Therefore we intended to investigate if patients benefit from an early growth ...

Background: It has been reported that primary treatment with somatostatin analogues (SSA) is effective in up to 60% of acromegaly patients, but predictive value of the acute octreotide suppression test (OST) for selection of patients with good response to depot SSA in long term treatment remains controversial.Patients and methods: Twelve medical therapy naive patients (mean age 44 years, female 75%) with active acromegaly were included in prospective stu...

Men living at high altitudes in Peru compared to sea level counterparts have erythrocytosis (Hemoglobin: 16–21 g/dl) or excessive erythrocytosis (Hemoglobin>21 g/dl). High testosterone (T) levels in men at high altitude (HA) were associated with excessive erythrocytosis. High androgen levels could be due to a low aromatase activity or to an elevated rate of conversion from precursors to testosterone. The aim of this study was to evaluate aromatase activity and rate of...

Purpose: Radiation-induced anterior pituitary hormone deficiencie is the most common long-term complications of successful cancer treatment. The aim of our study was to analyze thyroid status in young adults after radiotherapy in childhood and their relationship with dose of radiotherapy.Materials and methods: Thyroid function (TSH, free T4, free T3) and thyroid ultrasound were evaluated in 29 young adults with a history of radiotherapy for brain tumors ...

Purpose: The aim of the study was to investigate the influence of TSH and free thyroxin (fT4) hormones on carotid intima media thickness (cIMT).Material and methods: Sixty nine consecutive patients who attended to the Department of University Clinic of Endocrinology, Diabetes and Metabolic disorders with newly diagnosed subclinical hypothyroidism (ScH) were evaluated for mean and maximal cIMT. ScH were defined as elevated TSH with normal fT<su...

Although the physico-chemical properties of colloid are not usually considered among the factors regulating thyroid function, it is conceivable that decreasing the viscosity of the intrafollicular colloid may facilitate diffusion of thyroglobulin (Tg) molecules within the lumina. The resulting increase in the number of contacts between Tg molecules and peroxidase at the apical membrane may promote the coupling reaction. Rats on a hormonal diet were given 0.5 μg T4</s...

Introduction: We investigated short-term influence of thyroxin replacement therapy on blood pressure (BP) and cardiovascular status in patients with first identified primary hypothyroidism (PH) and earlier diagnosed arterial hypertension (AH).Methods: 52 patients with PH and AH were observed twice: prior to replacement therapy and after reaching euthyroid status. All patients underwent daily BP monitoring, echocardiography, and high frequency ultrasound ...

Introduction: Graves’ hyperthyroidism is an autoimmune disease sustained by autoantibodies binding to and activating the TSH receptor located on the thyroid follicular cell. The objective of study was to determine the presence of anti-receptor TSH antibodies for the diagnosis of Grave’s diseases and the following up after surgery, iodine and treatment with antithyroid drug.Results: In years 2006–2010 in our clinic in 265 patients for thyro...

A 17 year old girl was referred to us from the gynaecology department with history of primary amenorrhea. She was otherwise well and previous medical history included severe acne requiring referral to ENT, plastic surgery and dermatology services at age 13 and hirsutism for which she had privately funded laser treatment. On examination she had acanthosis nigricans and BMI of 22 but was virilised with clitoromegaly, hypertrophied labia majora and hirsuitism. Pelvic ultrasound r...

Heterophilic antibody interference in serum TSH immunoassays can result in misdiagnosis of patients with suspected thyroid disease. Rheumatoid factor (RhF) is an immunoglobulin with reactivity to the Fc portion of human IgG. Some RhF species also cross-react with animal immunoglobulins so have the potential to act as heterophile antibodies. As part of the Cambridge Supra-Regional Assay service for thyroid function testing five serum samples with strongly positive RhF and posit...