Endocrine Abstracts

Context: Transsphenoidal surgery (TSS) is the primary treatment of choice in acromegaly. It is important to identify patients in whom surgical cure is not attainable at an early stage, both to inform patients on expected treatment outcome and to select those who are more likely to need additional therapy.Objective: To identify predictors for remission and relapse after TSS in acromegaly.Design: Retrospective study in three large te...

Background: Insulinomas are the most prevalent functional neuroendocrine tumors of the pancreas. Enucleation is often preferred to pancreatic resection because it’s minimally invasive nature. The aim of this study is to assess the post-operative surgical outcome in particular pancreatic fistula after resection.Methods: All patients with insulinomas were selected from a retrospective database of resected pancreatic neuroendocrine tumors (pNET). Patie...

Background: Estrogen replacement therapy is the most effective treatment for postmenopausal (PMP) flushing, but its use is often contraindicated. An effective and safe alternative is urgently needed.Aim: To explore the effects of the LHRH receptor antagonist cetrorelix in women with severe PMP flushing who have a mean daily flush score >15.Methods: Open-label treatment with cetrorelix 250 μg twice a day in nine women with ...

In Europe more than 50 million adults are diabetic. Of these, 90–95% have type 2 diabetes (T2D). It is also recognized that an even larger population is insulin resistant and it is thought that treatment at this early phase of the metabolic syndrome may prevent the occurrence of overt diabetes and associated pathologies. We are in the process of developing unacylated ghrelin (UAG) analogues as therapeutics for T2D. Towards this goal, we have used a mouse protocol in which...

Aim: Patients with autoimmune thyroid disease (AITD) or type 1 diabetes (T1DM) are prone to develop other autoimmune diseases. This has led to the concept of autoimmune polyglandular syndromes (APS). It has been proposed that AITD and type 1 diabetes are both part of the same APS (subtype 2). This would imply that they associate with the same diseases. We evaluated whether the clustering of autoimmune antibodies differs between AITD and T1DM.Methods: Ant...

Introduction: Adrenocortical carcinoma (ACC) is a rare, but highly malignant endocrine tumor. Surgery is the primary choice of treatment. In case of inoperable disease or tumor recurrence, therapy with the adrenolytic drug mitotane is usually applied. Plasma mitotane concentrations of >14 mg/l (50 μM) seem required for an effect on tumor mass. Despite its clinical use, the effects of mitotane on cell proliferation and hormone production have been poorly investigated <...

Background: Testosterone (T) in a hydroalcoholic gel is commonly prescribed as androgen replacement therapy and may not be accompanied by peaks and troughs of serum T levels as seen in T-injectables. We assessed in 17 subjects the differences in serum testosterone (sT) and free T (fT) levels during four different application periods.Methods: Patients where on daily 50 mg Androgel®, for 7 consecutive days in each cycle, on day 8 serum was ...

Background: Obesity induced inflammation is a key component in the pathogenesis of insulin resistance (IR). In addition, obesity-related non-alcoholic fatty liver disease (NAFLD) also seems to contribute to IR development. Until now, however, it is unclear which, if any component of NAFLD specifically associates with IR. Therefore, the aim is to assess if individual components of NAFLD contribute to IR in obese patients undergoing gastric bypass surgery (GBS).<p class="abs...

Introduction: Corticosteroids are amongst the most prescribed drugs and their use has been linked to cardiometabolic adverse events including weight gain and abdominal adiposity. We previously showed that users were also more likely to have the metabolic syndrome (MetS). Since an essential role in the pathway of glucocorticoid (GC) action is reserved for the glucocorticoid receptor (GR), it could be proposed that GC sensitivity altering polymorphisms could affect the vulnerabi...

Background and aims: Obesity induced inflammation is a key component in the pathogenesis of insulin resistance (IR). In addition, obesity-related non-alcoholic fatty liver disease (NAFLD) also seems to contribute to IR development. Until now, however, it is unclear which, if any component of NAFLD specifically associates with IR. Therefore, the aim is to assess if individual components of NAFLD contribute to IR in obese patients undergoing gastric bypass surgery (GBS).<p c...