Searchable abstracts of presentations at key conferences in endocrinology

ea0081p386 | Endocrine-Related Cancer | ECE2022

Urinary steroid metabolomics for adrenocortical cancer diagnosis. Comparison of gas chromatography mass spectrometry to liquid chromatography mass spectrometry

Taylor Angela , Bancos Irina , Gilligan Lorna , van Veen Rick , Chortis Vasileios , Shaheen Fozia , Jenkinson Carl , O'Neil Donna M , Hughes Beverly , Hawley James M , Keevil Brian , Shackelton Cedric H L , Deeks Jonathan , Sitch Alice J , Biehl Michael , Arlt Wiebke

Introduction: Gas chromatography mass spectrometry (GC-MS) is the gold standard method for urinary steroid profiling. However, GC-MS requires chemical derivatisation, long run times, is labour intensive, expensive, and unsuitable for rapid multi-sample analysis, limiting its use in routine clinical practice. GC-MS urinary steroid metabolomics, the combination of steroid profiling and machine learning (Generalized Matrix Learning Vector Quantization) was shown to have superior ...

ea0081p198 | Reproductive and Developmental Endocrinology | ECE2022

Blue Morpho: An international survey investigating differences in emotional and psychosexual wellbeing by ethnicity and birthplace in women with polycystic ovary syndrome

Sheikh Jameela , Khalil Halimah , Shaikh Salomi , Hebbar Meghnaa , Zia Nawal , Wicks Saskia , Jayaprakash Sindoora , Subramanian Anuradhaa , Chapman Rachel , Gleeson Helena , Robinson Lynee , Chu Justin J. , Lathia Tejal , Selvan Chitra , O'Reilly Michael , Manolopoulos Konstantinos , Arlt Wiebke , Kempegowda Punith

Objective: This study investigated the association between ethnicity, birthplace and emotional and psychosexual wellbeing in women with Polycystic Ovary Syndrome (PCOS) in the community.Design: International cross-sectional study.Methods: Women with a self-reported PCOS diagnosis by a healthcare professional were invited to complete an online Blue Morpho questionnaire between September-October 2020 (UK) and May-June 2021 (India). F...

ea0081p457 | Reproductive and Developmental Endocrinology | ECE2022

A systematic review and meta-analysis assessing psychosexual wellbeing in people with polycystic ovary syndrome

Khalil Halimah , Malhotra Kashish , Sheikh Jameela , Hebbar Meghnaa , Zia Nawal , Jayaprakash Sindoora , Wicks Saskia , Subramanian Anuradhaa , Chapman Rachel , Gleeson Helena , Robinson Lynne , Chu Justin , Lathia Tejal , Selvan Chitra , O'Reilly Michael W. , Manolopoulos Konstantinos , Arlt Wiebke , Kempegowda Punith

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, with an estimated prevalence of 10-15% worldwide. PCOS can have adverse consequences on the emotional wellbeing of the patient. However, evidence exploring the relationship between PCOS and psychosexual wellbeing, specifically sexual function, and dysmorphic appearance concerns, is largely inconclusive.Aim: A systematic review and meta-analysis were undertaken to assess differ...

ea0081ep858 | Reproductive and Developmental Endocrinology | ECE2022

Perceptions and experiences of women with polycystic ovary syndrome- a systematic review

Mun Lau Gar , Elghobashy Mirna , Thanki Mansi , Ibegbulam Shirley , Gleeson Helena , Robinson Lynne , Latthe Pallavi , Gillett Caroline D. T , Arlt Wiebke , Lindenmeyer Antje , Kempegowda Punith , SEva Working Group PCOS

Introduction: With a global prevalence of around 10%, polycystic ovary syndrome (PCOS) is a common endocrine condition affecting women. Despite its prevalence, limited evidence exists around the condition and its impact on patients. Qualitative research provides insights into symptoms and experiences faced by women with PCOS that can affect management and compliance.Aim: A systematic review was undertaken to evaluate the current literature on ...

ea0081ep898 | Reproductive and Developmental Endocrinology | ECE2022

PCOS SEVa: High prevalence anxiety and body dysmorphia in women with PCOS attending specialist care in the UK and India

Hebbar Meghnaa , Shaikh Salomi , Zia Nawal , Sheikh Jameela , Wicks Saskia , Jayaprakash Sindoora , Narendran Alisha , Khalil Halimah , Gleeson Helena , Robinson Lynne , Ch Justin J. , Lathia Tejal , Selvan Chitra , Arlt Wiebke , Kempegowda Punith

Introduction: National Institute of Health and Care Excellence (NICE) recommends screening for emotional wellbeing as part of consultations for polycystic ovary syndrome (PCOS).Aim: We evaluated several dimensions of emotional wellbeing in people attending PCOS consultation with specialists in the UK and India.Methods: All people attending specialist clinics in a tertiary centre in the UK from October 2020 to September 2021 and in ...

ea0081ep909 | Reproductive and Developmental Endocrinology | ECE2022

PCOS pearls - findings from the qualitative study assessing the lived experience of people with polycystic ovary syndrome

Elghobashy Mirna , Lau Gar Mun , Busby Maureen , Stacke Kristine , Latthe Pallavi , Gleeson Helena , Robinson Lynne , Arlt Wiebke , Lindenmeyer Antje , Gillett Caroline D. T , Kempegowda Punith , Seva Working Group PCOS

Introduction: Existing educational resources for polycystic ovary syndrome (PCOS) have limited inclusion of patient perspectives. We invited women with PCOS to share their lived experiences to understand their perception and opinion on the current standard of care.Methodology: Women with PCOS aged 18-60 years were invited to complete an online survey in April and May 2021. The survey had open questions focused on their lived experiences with PCOS. Partic...

ea0050oc1.3 | Early Career Oral Communications | SFEBES2017

Antioxidant pathway targeting as a therapeutic approach in adrenocortical carcinoma

Chortis Vasileios , Taylor Angela E. , Doig Craig L. , Meimaridou Eirini , Walsh Mark , Jenkinson Carl , Rodriguez-Blanco Giovanny , Jafri Alisha , Ronchi Cristina , Metherell Louise A. , Hebenstreit Daniel , Dunn Warwick B. , Arlt Wiebke , Foster Paul A.

Adrenocortical Carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. Here we evaluated a potential new treatment target for ACC, focusing on the mitochondrial NADPH generator Nicotinamide Nucleotide Transhydrogenase (NNT). NNT has a central role within the mitochondrial antioxidant pathways, protecting cells from oxidative stress. Inactivating NNT mutations lead to isolated primary adrenal insufficiency, suggesting a selective vulnerability of adrenoc...

ea0050oc1.3 | Early Career Oral Communications | SFEBES2017

Antioxidant pathway targeting as a therapeutic approach in adrenocortical carcinoma

Chortis Vasileios , Taylor Angela E. , Doig Craig L. , Meimaridou Eirini , Walsh Mark , Jenkinson Carl , Rodriguez-Blanco Giovanny , Jafri Alisha , Ronchi Cristina , Metherell Louise A. , Hebenstreit Daniel , Dunn Warwick B. , Arlt Wiebke , Foster Paul A.

Adrenocortical Carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. Here we evaluated a potential new treatment target for ACC, focusing on the mitochondrial NADPH generator Nicotinamide Nucleotide Transhydrogenase (NNT). NNT has a central role within the mitochondrial antioxidant pathways, protecting cells from oxidative stress. Inactivating NNT mutations lead to isolated primary adrenal insufficiency, suggesting a selective vulnerability of adrenoc...

ea0086oc4.5 | Adrenal and Cardiovascular | SFEBES2022

Comparison of prednisolone and modified-release hydrocortisone capsules in the treatment of congenital adrenal hyperplasia: dose and disease control

Rees Aled , Merke Deborah , Arlt Wiebke , Pierriere Aude , Hirschberg Angelica , Juul Anders , Newell-Price John , Perry Colin , Prete Alessandro , Reisch Nicole , Stikkelbroeck Monica , Touraine Philippe , Coope Helen , Lewis Alexander , Porter John , Ross Richard

Introduction: First-line treatment for congenital adrenal hyperplasia (CAH) is hydrocortisone1. When adequate control is not achieved, prednisolone (or its prodrug prednisone) are often used. However, there has been no formal comparison of disease control in CAH comparing prednis(ol)one vs hydrocortisone and patients are often on a glucocorticoid dose that exceeds the guideline recommended dose of hydrocortisone (≤25 mg/day)1,2. We report an interim...

ea0065ec1.2 | Early Career Prize Lecture Translational | SFEBES2019

From bench to bedside and beyond: a novel therapy to improve wound healing in type 2 diabetes

Ajjan Ramzi , Hensor Elizabeth , Abbas Afroze , Galdo Francesco Del , Russell David , Shams Kave , Stewart Paul , Webber Lorraine , Pegg Lindsey , Freeman Adrian , Woods Janet , Eng Sookhoe , Taylor Angela , Arlt Wiebke , Tahrani Abd , Tiganescu Ana

The International Diabetes Federation estimates that type 2 diabetes mellitus (T2DM) will affect 642 million people by 2040. Chronically inflamed, hypoxic wounds are common in T2DM and represent a global unmet clinical need. Each year, diabetic foot ulcers cost the NHS £650 million and cause 1 in 200 UK deaths. This mortality is greater than colon, breast and prostate cancer combined. Glucocorticoids are used to treat a range of inflammatory conditions (e.g. asthma, eczem...