Endocrine Abstracts

Context: The biological diagnosis of adrenal disorders is currently based on the quantitation of serum steroids using automated immunoassays. These direct assays often lack the required accuracy and precision and interlaboratory surveys show that performance characteristics of MSMS are far better than those of automated immunoassays.Method: After liquid chromatography of serum extracts, steroids were quantified on Waters QuattroPremier mass-spectrometer ...

Purpose: The aim of this study was to evaluate the functional status and growth rates of adrenal incidentalomas, diagnosed at our center between 2005 through 2010.Methods: The computer and archive records of 113 patients, diagnosed as adrenal incidentalomas and followed-up at our center, were retrospectively analysed.Results: A total of 113 patients (133 tumors, 80 women (%70.8) and 33 men (% 29.2), ranged in age between 27 and 77 ...

Teriparatide (TPTD) reduces the vertebral and nonvertebral fracture risk. TPTD increases bone formation and improves the cancellous bone microstructure which is an important determinant of the mechanical integrity of vertebrae. The aim of our study was to evaluate first time the effect of TPTD on cortical microstructure and dynamic histomorphometric indices in patients with osteoporosis with or without prior therapy with ALN. Sixty-six postmenopausal women with osteoporosis, m...

Involvement of BMP-3b (also called GDF-10) in osteogenesis, embryogenesis and adipogenesis has been reported to date. However, the functional receptors and intracellular signaling of BMP-3b have yet to be determined. In the present study, we studied the cellular mechanism of BMP-3b in osteoblast differentiation using mouse myoblastic C2C12 cells, which show osteoblasitc differentiation in response to osteogenetic BMP ligands. BMP-3b stimulated activin/TGF-β-responsive pro...

Introduction: A relationship between osteopenia/osteoporosis and calcium nephrolithiasis has been recognized in several studies. An association has also been observed between bone mineral density loss, hypercalciuria, hypocitraturia and nephrolithiasis.The aim of this study was to analyze the effects of aminobisphosphonates and thiazides on renal lithogenic activity and bone mineral density in patients with recurring renal calcium lithiasis.<p class=...

Osterix (Osx) is an essential transcription factor for osteoblast differentiation and bone formation. Osx null mutants died perinatally with a complete absence of bone formation and Osx conditional knockouts in osteoblasts showed the osteopenic phenotype after birth. Even in Osx heterozygous mice with normal bone morphology, the reduced cortical thickness and osteoblast differentiation were observed by QCT and in vitro cell culture, respectively. This result exhibited t...

Introduction: Calcium nephrolithiasis is the most frequently diagnosed type of nephrolithiasis. It is related to metabolic alterations, inhibitor deficiencies, anatomical factors, alterations in urinary pH, and bone alterations.The objective of this study is to analyze the alterations in bone mineral density and bone and calcium-phosphorus metabolism in patients with calcium nephrolithiasis.Methods/design: We designed a study with ...

Introduction: Male gender, adolescence and obesity are known risk factors for upper limb fractures, although the mechanism by which obesity confers the increased fracture risk is unknown. In addition, most studies investigating the influence of body fat mass on bone in adolescents have been performed in school based populations using the DXA technique, which does not take into account the material and geometric bone properties.Methods: We investigated vo...

Background: The study aimed to evaluate quality-of-life (QoL) aspects and impact of vitamin D deficiency in primary hyperparathyroidism (pHPT).Method: One hundred and fifty consecutive patients (119 women) with pHPT (mean age 60±11 years; BMI 27±5 kg/m2; ionized calcium 1.44±0.08 mmol/l; PTH 130±69 ng/l) were included. Six weeks postoperatively, the pHPT patients were reexamined and randomized (double-blind) to daily substi...

Introduction: One of the factors influencing a predisposition to calcium renal lithiasis is a lack of crystallization inhibitors, the most important of which is citrate. The aim of our study was to analyze the importance of urinary citrate and the urinary calcium/citrate ratio in patients with calcium renal lithiasis and severe lithogenesis in comparison with control group patients without lithiasis.Methods/Design: We conducted a cross-sectional study of...