Endocrine Abstracts

Introduction: Quadruple primary malignancies occur with an incidence of <0.1% and <100 cases have been published to our best knowledge. We are presenting a patient with multiple sclerosis and triple thyroid carcinoma, double melanoma and a breast cancer.Case report: Over the course of 4 years we treated a single patient due to stage III (T3, N1a, M0) medullary thyroid carcinoma size 45 mm in the right lobe and two micropapillary carcinomas in the...

Patient C Caucasian male, 41 years old was admitted to the inpatient department of endocrinology with newly diagnosed T2 DM, morbid obesity on the 03.03.2011.Anamnesis: Overweight since childhood, but in the past few years he started to gain weight rapidly (because of smoking cessation). Arterial hypertension since 2003, with maximum increase up to 210/125 and he took antihypertensive drugs regularly. In 2006 painless myocardial ischemia was f...

Introduction: Glitazones’ admisitration has been proved to affect EPCs in peripheral circulation in endothelial function and inflammatory process. The purpose of this study was to further investigate if the administration of pioglitazone in diabetics can modify the number of EPCs in the peripheral blood and alter the inflammatory state and endothelial function of these patients.Methods: Twenty five diabetic patients were recruited and pioglitazone w...

Introduction: Endothelial progenitor cells (EPCs) seems to be reduced in patients with diabetes mellitus, however it is unknown whether treatment with ACE-I may modify the number of EPCs. Therefore, the purpose of this study was to investigate if the administration of perindopril in diabetic patients with and without coronary artery disease can modify the number of circulating EPCs and alter their inflammatory state and endothelial function.Methods: Twen...

Background: South Asians have a higher prevalence of diabetes and increased complications compared to other ethnic minorities, leading to poorer health outcomes. There is a lack of evidence about knowledge of diabetes self-care behaviors amongst this group. Having such knowledge is crucial in preventing complications and providing effective health services.Objectives: The aim of this study was to identify knowledge of self-care behaviors and factors comp...

Background: Gestational diabetes mellitus (GDM) is a common pregnancy condition which is associated with long term complications. In this study we examined the levels of inflammatory mediators, adiponectin, hemocystein and insulin resistance index in women with and without previous GDM (pGDM). Also association between these factors and early atherosclerosis process was evaluated.Methods: Serum levels of IL6, hs-CRP, adiponectin, homocystein and other bio...

Introduction: The continuous subcutaneous insulin infusion (CSII) is an alternative to multiple daily injection therapy in type 1 diabetes and its use is increasingly common due to the beneficial effects on the glycemic control of the patient.Aims: To find differences on outcomes of CSII therapy between genders. Patients and methods: Patients on CSII therapy in our department were included in the study and we recorded outcomes regarding the following set...

Aims: To compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart, biphasic insulin aspart 70 (BIAsp70), biphasic insulin aspart 50 (BIAsp50) and soluble human insulin under experimental conditions.Methods: In this randomised, four-period crossover study, 19 type 1 diabetic patients received subcutaneous injections of identical doses (0.2 U/kg) of either insulin aspart, BIAsp70, or BIAsp50 immediately before a standardized meal, or huma...

Introduction: Pituitary adenomas account for 10–25% of all intracranial tumours. Although rarely malignant, they are associated with high morbidity due to severe endocrine effects and difficult surgical access. Alternative splicing (AS) consists in selective removal of non-coding regions from pre-mRNA and joining of coding regions to produce mRNA variants that may be further translated. AS is regulated by splicing factors and is often disturbed in cancer. AS of growth hor...

Insulinoma is a very rare type of islet cell tumor. The aim of our study is to report our clinical experience with insulinoma in order to determine clinical, biological, radiological and therapeutic particularities of this tumor type.It’s a retrospective study, including five patients (three women and two men) referred to our department between 2005 and 2011 for hypoglycemia exploration. Mean age of our group is 39.8±15.4 years (ranges: 20&#150...