Endocrine Abstracts

Objective(s): Single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (eNOS) G894T may affect the oxidative stress–response. Our objective was to examine G894T SNP eNOS genotype frequencies and its potential role with sperm motility in infertile men. Through this prospective controlled study in the Andrology Unit, we have enrolled infertile (n=70) and healthy (n=60) men. Sperm motion kinetics assessed by computer assisted semen analysis (CA...

This research was designed to estimate effectiveness and safety of Lindaxa in treatment of obesity associated with IGT and arterial hypertension. Thus, 20 women (mean age 37.9 years-old) were treated with complex therapy including traditional therapy (diet, physical exercises, dhydration, metabolic and symptomatic treatment) including Lindaxa with dosage of 10–15 mg/day once daily during 6 months. Physical exercises were determined individually according to BMI and metabo...

It was reported that the inhibition of central nervous system (CNS) axon growth is mediated by Ca2+-dependent phosphorylation of epidermal growth factor receptor (pEGFR) and that local administration of small molecule EGFR antagonists to optic nerve lesions promoted retinal ganglion cell (RGC) axon regeneration (Koprivica et al. 2005). This result was attributed to suppression of EGFR kinase, which neutralised the axonal growth inhibitory potency of CNS myeli...

To explore the correlation structure of individual components of the Metabolic Syndrome and identify combinations of correlated variables we used principal component analysis (PCA) in a multiethnic group of women with a history of GDM (pGDM) (185 European, 103 South Asian, 80 African–Caribbean), recruited at 20.0 (18.2–22.1) months (geometric mean (95% CI)) after pregnancy and 482 control women of similar ethnicities. BMI, W:H ratio, systolic and diastolic BP, f. glu...

Polyunsaturated fatty acids (PUFA) act as precursors for prostaglandin (PG) synthesis. PGs both inhibit and stimulate ovarian steroidogenesis. We have therefore examined the hypothesis that high n-3 PUFA diets affect ovarian steroid synthesis through modulating prostaglandin synthesis.Welsh mountain ewes were individually fed a control diet or a diet containing linseed (high in n-3 PUFA) for 6 weeks. To assess the impact of the diet during differe...

We report the case of a 55 years old female patient with parallel appearance of mucoepidermoid carcinoma and papillary thyroid carcinoma. She had autoimmune adrenal insufficiency and a pulmonary adenocarcinoma cured by lobectomy and external irradiation six years before. She had been referred to our department because of a rapidly growing thyroid nodule. Aspiration cytology suspected papillary tumor and a tumor of non-thyroid origin as well. Thyroidectomy and bilateral neck ly...

Understanding the molecular factors that regulate human muscle mass is acquiring increasing scientific interest. Hitherto, known (+ve) endocrine regulators of lean body mass included the GH-IGF-1 system, anabolic steroids, and (−ve) myostatin. In order to elucidate this process further, we have investigated a clinical case at a genetic and phenotypic level. A 46-year-old man with idiopathic muscle hypertrophy requiring multiple therapeutic fasciotomies underwent clinical...

The prevalence of cardiovascular diseases (CVD) has increased sharply in the developing countries and because Type 2 diabetic patients are at increased risk for CVD.Objective: To determine the prevalence of patients with past hystory of a myocardial infarction or cerebral strok in newly diagnosed type 2 diabetic patients in Georgia.Design: Cross-sectional study.Patients: Newly diagnosed type 2 diabetic patien...

Obesity/Metabolic syndrome (insulin resistance, hypertension, cardiovascular disease) has reached epidemic levels in western societies. Aberrantly elevated glucocorticoid amplification by intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) within adipose tissue might explain the striking similarities between idiopathic obesity/metabolic syndrome and Cushing’s syndrome, causes by plasma GC excess. A major contributor to obesity/metabol...

Introduction: Characteristic localisations of metastases of differentiated thyroid carcinoma (DTC) include local lymph nodes, the lungs and bones, while the incidence of DTC metastases onto the liver, the brain and skin is clearly lower. The localisation of metastases in other organs, including the kidneys, is very rare.Material and methods: A case of a 73–year-old patient with thyroid oxyphilic carcinoma is reported, the case being diagnosed in 199...