Endocrine Abstracts

The leptin receptor (ObR) exists in multiple isoforms. In humans, there is no mRNA encoding soluble receptor (LBP). We investigated the hypothesis that human LBP can be generated by proteolytic cleavage of membrane anchored leptin receptors (ObRb and ObRa). LBP, of similar size to that previously detected in human serum, was detected in medium of cells transfected with ObRa by HPLC, Immunofluorometric assay, and Ligand mediated immunofluorometric assay, but not by ELISA. The L...

Osteoporosis is one of the most common bone diseases whose complications, morbitidy and mortality impose direct and indirect expenses. Vitamin-D is one of the most important factors in calcium absorption for bone formation. In this study we have evaluated vit-D level and other calcium metabolism indicators in urban population of Tehran.In a cross-sectional study in winter 2001, 1231 normal persons; 20-69 years, 502 male and 724 female, among urban popula...

The influence of the hypothyroidism (H) on the glucose metabolism (GM) has not been studied by modern methods till now. We described the changes in the effect of insulin on GM in patients in artificial H and after the thyroid hormone therapy (T).Materials and Methods: We have investigated 15 female patients (age 32.8 plus/minus 8.1 years) in H (ssTSH 84.45 plus/minus 19.69 milli international units per litre; fT4 1.68 plus/minus 0.77 picomoles per litre;...

Introduction: Pembrolizumab is an immune checkpoint inhibitor (ICI) used to treat advanced cancers. While improving survival rates, ICIs also cause immune-related adverse events (IRAEs). The endocrine system remains the most vulnerable to IRAEs: thyroid involvement is the commonest while pancreatic involvement is rare, affecting less than 1% of individuals. Risk factors for IRAEs include, personal or family history of autoimmune conditions, presence of another...

Purpose: Papillary and follicular cancers are classified as differentiated thyroid cancers. Recently, it has been revealed that Neutrophile/lymphocyte ratio (NLO) and the ratio of monocyte/lipoprotein cholesterol with high density (MHR) are the strong indicators of oxidative stress and systemic inflammation. In this study, we intend the evaluation of all these indicators in our patients diagnosed with differentiated thyroid cancers.Method: This study inc...

Background: Cushing’s syndrome is a well-known risk factor for endothelial dysfunction, cardiovascular morbidity and mortality.Objectives: We aimed to prospectively investigate changes in metabolic and cardiovascular parameters and their correlations with markers of endothelial function in patients with endogenous Cushing syndrome following remission. Methods: Adult patients newly diagnosed with endogenous Cushing’s Syndr...

Introduction: It is known that many metals can contribute to thyroid dysfunction. Mercury (Hg) has attracted the attention of researchers because it is widespread in the environment (food, air, soil). However, only several studies deal with the exposure to low doses of Hg, which may reflect the real exposure of the general population.Aim: This study examined the relationship between measured concentrations of Hg in the blood and levels of free thyroxine ...

Aim: We aimed to examine the relationship between the healthy eating index (HEI) and steroidogenesis in polycystic ovary syndrome (PCOS) patients and healthy controls.Materials and Methods: In addition to demographic records and routine biochemical tests, HEI was calculated from three-day nutritional records in the Bebis program. Adrenal steroidogenesis panel was measured by LCMS.Results: The study included 50 women with PCOS and 4...

Objectives: Acute bacterial or viral CNS infections have been shown to result in hypopituitarism during the acute phase, and 6–24 months after the event in a few studies. However, there are no data in the literature regarding the long term pituitary functions after acute CNS infections. This cross-sectional study was designed to evaluate the pituitary functions long-term after the acute bacterial or viral CNS infections.Methods: 19 patients with age...

Endocrine disruptors are chemicals which in low concentrations can disturb gene expression in a range of endocrine glands and organs including the fetal and adult adrenal glands, potentially resulting in altered steroidogenic flux. With exposure to endocrine disruptors affecting both animals and humans, it is important to assess both the mechanisms and consequences of disruption in steroidogenic pathways, particularly as foetal development may be especially sensitive to endocr...