Endocrine Abstracts

The purpose of this work was to investigate the effect of thyrotropin (TSH) on the thyroglobulin and on the polypeptides distribution in primary cultures of human thyroid cells.Thyroid cells isolated from cold nodules (follicular adenoma) were cultured for 5 to 8 days in the presence of 0.05 to 25 mU/ml of TSH (TSH cells) or in the absence of the hormone (control cells). After homogenization of the cells, thyroglobulin radioimmunoassay was performed. The...

ACE inhibitor, lizinopril, reduced cerebrovascular death, myocardial infarction and stroke. It also reduced diabetic nephropathy and increased sensitivity of insulin in people with diabetes.The aim of this study was to determine the effects of lizinopril on cerebrovascular death, myocardial infarction, stroke, nephropathy and insulin sensitivity. Sixty patients with diabetes mellitus type 2, mean age 58.6 plus/minus 5.6 years, with similar BMI, were div...

Recent studies revealed that the elevated tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) serum levels were associated with body fat, especially visceral adiposity, in obese healthy subjects. We investigated the relationship between circulating TNF-alpha and IL-6, parameters of body fatness, and the metabolic syndrome in chronic renal failure maintenance hemodialysis patients.Methods: We explored the relationships between fatness and vis...

Circadian mechanisms regulate metabolism in adipose tissues. The genes encoding the circadian regulatory proteins oscillate over a 24 h period in human and murine adipose tissue depots,. This expression profile is entrained by photic stimuli, temporally restricted food access, and/or nuclear hormone receptor ligands, such as glucocorticoids. In mice, deletion or mutation of the circadian regulatory genes, clock and PPAR gamma coactivator 1 (PGC1), is associated with increased ...

Introduction: Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is one of the most common autosomal recessive hereditary diseases. There are two main forms of CAH: early onset, the classic variety, and late onset or non classic type. Here, we aim to describe the case of a young lady with features of both varieties of CAH.Case report: Twenty-three-year-lady of Asian descent presented with polymenorrhagia since menarche (age 13 years), ...

Introduction: Autoimmune polyendocrine syndrome type II (APSII) is more common than APSI. It occurs more frequently in female than in male patients, often has its onset in adulthood, and has familial aggregation. Schmidt’s syndrome is a subset of APSII, usually associated with primary hypothyroidism, primary adrenal insufficiency, and often, type 1 diabetes. This case describes the interesting evolution of autoimmune polyendocrine disease (APED) in a young lady with long ...

We examined the effects of L-thyroxin on level of prolactin (PRL), CRP (C-reactive protein) and insulin in premenopausal women with subclinical hypothyreoidism (SH).The study included 21 women ages 41.3±3.5 years with SH (TSH>mIU/ml with normal level of T3 and T4).Laboratory evaluation included basal hormone (serum free T3, free T4, TSH, PRL, insulin, cortisol, ACTH, GH, FSH, LH, E2, thyroid antibodies and TGL), level of C...

Introduction: Recent studies claim that microRNAs (miRNAs) participate in the pathogenesis of coronary artery disease (CAD).Objective: To study miRNA expression in patients with obesity, determine their association with CAD.Methods: MiRNAs were detected in peripheral blood. 66 patients with BMI 30.0–39.9 kg/m2 were divided into 3 groups: 1st – with CAD and T2DM, 2nd – with T2DM and excluded CAD, 3rd –...

The more sophisticated laboratory methods are used, the more likely a disease is found at its asymptomatic stage. In particular, diagnosis of primary hyperparathyroidism (PHPT) is currently based not only on the presence of clinical symptoms but on the typical upswing of the serum parathyroid hormone level. Outlooks of patients with PHPT and normal serum calcium level have not been quite clear so far. We tried to contribute to this question in a prospective study that has been...

Introduction: Vitamin D deficiency is a common disorder and may manifest as a musculoskeletal, neurological, mental disorder or neoplastic disease.Case report: A 47 year old woman of Caucasian origin suffered from back, muscle, bone pain and severe depression for 8 years. She was ineffectively treated at the departments of Neurology, Psychiatry, Pain Clinic several times a year. Brain, bone CT, internal ultrasound, routine biochemistry analyses were norm...