Endocrine Abstracts

Case: A 52-year-old gentleman was admitted with dizziness and collapse. Past medical history revealed dyslipidemia treated with statin. Physical examination was unremarkable. Initial investigations were consistent with SIADH (sodium: 109 mmol/l, serum osmolality: 243 mOsm/kg, urine Na: 59 mmol/l and urine osmolality: 191 mOsm/kg). Urea, creatinine and random glucose were normal. CT Head showed pituitary enlargement with sellar expansion. Pituitary profile showed high prolactin...

Acute intermittent porphyria (AIP) is an autosomal dominant disease due to deficient Porphobilinogen (PBG) deaminase activity. Hyponatremia, found in approximately 20% of symptomatic AIP, is often due to inappropriate ADH secretion (SIADH). An association between AIP and hyperthyroidism is not clearly established. We describe a patient with AIP and SIADH who presented with Graves’ hyperthyroidism. A 35-year-old lady was admitted with lower abdominal pain. Physical examina...

Introduction: Women with polycystic ovary syndrome (PCOS) have a clustering of cardiovascular risk factors, such as obesity, lipid abnormalities, impaired glucose tolerance, insulin resistance and hypertension. Exercise is reported to lower cardiovascular morbidity and mortality and improve reproductive health. The effect of exercise on plasma adiponectin and the components of leptin system, namely plasma free (FL) and bound (BL) leptin concentrations, have not been previously...

Introduction: Hirsutism, the presence of terminal (coarse) hairs that appear in a male-like pattern, affects 5–10% of women and may cause concern for an underlying endocrine disorder or malignancy. Spironolactone compete for the androgen receptor in the hair follicle, therefore, it is frequently used in treatment of hirsutism. We report a case, in which treatment of hirsutism with Spironolactone interfered with androstenedione immunoassay and raised unnecessary concern ab...

BackgroundThe role of endocrine testing in idiopathic gynecomastia is controversial. Previous studies suggested that such testing is rarely productive and best done selectively.ObjectivesA retrospective study was performed to evaluate the usefulness of a routine endocrine testing in patients presenting with gynecomastia.MethodsThe medical records of 71 patients wi...

Introduction: Adrenaleukodystrophy is an X linked disorder associated with functional defect of very long fatty acid (VLFCA) oxidation leading to accumulation of VLFCA in the white matter of brain and adrenal cortex. It usually presents with adrenal insufficiency and neurological problems and has association with other autoimmune conditions reported so far including vitiligo, ulcerative colitis. We report a case of adrenaleukodystrophy, vitiligo and hypothyroidism.<p class...

Carbimazole is a commonly used antithyroid drug with a rare but potentially life-threatening side effect of agranulocytosis. We present a case of a 47-year-old lady who was diagnosed with hyperthyroidism four years previously and treated with carbimazole despite persistent neutropenia.At diagnosis the patient had clinical features of hyperthyroidism and thyroid function test (TFT) showed free T4 40.8 pmol/l (10.6–21.0), free T3...

Introduction: Weight gain following treatment of hyperthyroidism is well recognised. This may lead to compliance problems both in patients with/without eating disorders and subsequent failure of therapy. We describe two cases where this was successfully managed with supervised in-patient therapy.Case 1: A 30-year-old overweight lady was diagnosed with Grave’s disease following childbirth. Thyroid function test (TFT) at initiation of treatment showed...

Introduction: Osteogenesis imperfecta (OI) is classified on the basis of molecular genetics, mode of inheritance, clinical and radiological findings. The genes implicated are either COL1A1 or COL1A2. We report a case of a novel mutation of OI in the COL1A2 gene.Case: A 24-year-old teacher with type 1 Diabetes Mellitus, presented to our Endocrine Clinic with recurrent fractures since childhood. At 7 months old, she fractured her left leg. At...

Introduction: Hypercalcaemia during pregnancy poses a risk to both the mother and foetus and can present a complex management issue. Although hypercalcaemia from any cause can occur during pregnancy, primary hyperparathyroidism is the most common cause but other rarer cause such as familial hypocalciuric hypercalcaemia (FHH) should be ruled out. Although usually posing no risk to the mother, infants of mothers with the disease are at risk for neonatal hypocalcaemia, and seizur...